A5047501668- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Cytomegalovirus and herpesvirus research
- Cardiac Fibrosis and Remodeling
- Eosinophilic Disorders and Syndromes
- Pericarditis and Cardiac Tamponade
- interferon and immune responses
- Parvovirus B19 Infection Studies
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- Viral gastroenteritis research and epidemiology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Virus-based gene therapy research
- Cardiovascular Function and Risk Factors
- Ion Transport and Channel Regulation
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Cardiac pacing and defibrillation studies
- RNA regulation and disease
- Advanced MRI Techniques and Applications
University Children's Hospital Tübingen
2016-2025
St. Joseph's Hospital
2025
University of Tübingen
2015-2024
Universitätsklinikum Tübingen
2015-2024
Hertie Institute for Clinical Brain Research
2022-2024
Saint Joseph Hospital
2024
TH Bingen University of Applied Sciences
2023
RWTH Aachen University
2022
Universitätsklinikum Gießen und Marburg
2022
Corvid Technologies (United States)
2022
In this position statement of the ESC Working Group on Myocardial and Pericardial Diseases an expert consensus group reviews current knowledge clinical presentation, diagnosis treatment myocarditis, proposes new diagnostic criteria for clinically suspected myocarditis its distinct biopsy-proven pathogenetic forms.The aims are to bridge gap between tissue-based diagnosis, improve management provide a common reference point future registries multicentre randomised controlled trials...
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
Background— Myocarditis can occasionally lead to sudden death and may progress dilated cardiomyopathy in up 10% of patients. Because the initial onset is difficult recognize clinically diagnostic tools available are unsatisfactory, new strategies diagnose myocarditis needed. Methods Results— Cardiovascular MR imaging (CMR) was performed 32 patients who were diagnosed with by clinical criteria. To determine whether CMR visualizes areas active myocarditis, endomyocardial biopsy taken from...
Background— Enteroviruses and adenoviruses have been considered the most common causes of viral myocarditis, but parvovirus B19 (PVB19) human herpesvirus 6 (HHV6) are increasingly found in endomyocardial biopsy samples. Methods Results— Consequently, our aim was to evaluate prevalence clinical presentation cardiac PVB19 and/or HHV6 infection a cohort myocarditis patients follow its course. In addition, we sought demonstrate patterns myocardial damage determine predictors for chronic heart...
Background— The objective of this study was to identify the prognostic indicators in patients with suspected myocarditis who underwent endomyocardial biopsy. Methods and Results— Between 1994 2007, 181 consecutive (age, 42±15 years) clinically viral were enrolled followed up for a mean 59±42 months. Endomyocardial biopsies studied inflammation histological (Dallas) immunohistological criteria. Virus genome detected by polymerase chain reaction. primary end point time cardiac death or heart...
Coxsackievirus B3-induced myocarditis in different immunocompetent mouse strains was used as a model to investigate interrelationships between virus replication and development of chronic enteroviral heart disease. Using situ hybridization detect RNA, we show that muscle infection is not only detected acute but also during the phase B3 could evade immunological surveillance host-dependent fashion, thus inducing persistent myocardium association with ongoing inflammation. Patterns myocardial...
Background— Endomyocardial biopsy (EMB) represents the gold standard for diagnosing myocarditis and nonischemic cardiomyopathies. This study focuses on risk of complications respective diagnostic performance left ventricular (LV), right (RV), or biventricular EMB in patients with suspected and/or cardiomyopathy unknown origin. Methods Results— In this 2-center study, 755 clinically (n=481) origin including those infiltrative connective tissue disease (n=274) underwent either selective LV-EMB...
Influenza A viruses are a threat to humans due their ability cross species barriers, as illustrated by the 2009 H1N1v pandemic and sporadic H5N1 transmissions. Interspecies transmission requires adaptation of viral polymerase importin-α, cellular protein that mediates transport into nucleus where transcription replication genome takes place. In this study, we analysed replication, host specificity pathogenicity avian mammalian influenza viruses, in importin-α-silenced cells...
Abstract Aims Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has emerged as a global pandemic. SARS-CoV-2 infection can lead to elevated markers of cardiac injury associated with higher risk mortality. It unclear whether direct cardiomyocytes or mainly secondary lung inflammation. Here, we investigate are permissive for infection. Methods results Two strains infected human induced pluripotent stem cell-derived demonstrated detection...
Systemic immune-mediated diseases (SIDs) include autoimmune and autoinflammatory (AD) affecting at least two-organ systems.1 Autoinflammatory refer to a growing family of conditions characterised by episodes unprovoked inflammation in the absence high autoantibody titres or auto reactive T lymphocytes, reflecting primary innate immune system dysfunction.1 Conversely, are aberrant B, dendritic cell responses, leading break tolerance against self-antigens, with predominantly cell-mediated...