A5005976602- Viral Infections and Immunology Research
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Assays
- Medical and Health Sciences Research
- Renin-Angiotensin System Studies
- Neuropeptides and Animal Physiology
- Eosinophilic Disorders and Syndromes
- Cardiac Fibrosis and Remodeling
- Cardiovascular Disease and Adiposity
- Cardiac tumors and thrombi
- Cell Adhesion Molecules Research
- Infective Endocarditis Diagnosis and Management
- Systemic Sclerosis and Related Diseases
- Advanced MRI Techniques and Applications
- Pericarditis and Cardiac Tamponade
University of Würzburg
2012-2024
Universitätsklinikum Würzburg
2015-2024
Friedrich Schiller University Jena
2022
Jena University Hospital
2022
Medizinische Hochschule Hannover
2022
Comprehensive Cancer Center Mainfranken
2014-2021
Biobanking and Biomolecular Resources Research Infrastructure Consortium
2017
MRB Research Center for Magnetic Resonance Bavaria
2013
Ludwig-Maximilians-Universität München
2007-2012
Bavarian Research Alliance
2012
In this position statement of the ESC Working Group on Myocardial and Pericardial Diseases an expert consensus group reviews current knowledge clinical presentation, diagnosis treatment myocarditis, proposes new diagnostic criteria for clinically suspected myocarditis its distinct biopsy-proven pathogenetic forms.The aims are to bridge gap between tissue-based diagnosis, improve management provide a common reference point future registries multicentre randomised controlled trials...
Background— Trials investigating efficacy of disease management programs (DMP) in heart failure reported contradictory results. Features rendering specific interventions successful are often ill defined. We evaluated the mode action and effects a nurse-coordinated DMP (HeartNetCare-HF, HNC). Methods Results— Patients hospitalized for systolic were randomly assigned to HNC or usual care (UC). Besides telephone-based monitoring education, addressed individual problems raised by patients,...
Peptide mimicry breaks the heart Myocarditis, a prolonged chronic inflammation of muscle, can eventually progress to inflammatory cardiomyopathy, serious condition associated with failure. Activated T helper (T H ) cells that recognize myosin heavy chain 6–derived peptides are thought play central role in this pathogenesis. Using mouse model myocarditis, Gil-Cruz et al. found cardiac myosin–reactive initially primed by myosin-peptide mimics derived from commensal Bacteroides species gut (see...
Today, dilated cardiomyopathy (DCM) represents the main cause of severe heart failure and disability in younger adults thus is a challenge for public health. About 30% DCM cases are genetic origin; however, large majority sporadic, viral or immune pathogenesis suspected. Following established postulates autoimmune diseases, here we provide direct evidence that an attack directed against cardiac β1-adrenergic receptor may play causal role DCM. First, immunized inbred rats second extracellular...
Today, dilated cardiomyopathy (DCM) represents the main cause of severe heart failure and disability in younger adults thus is a challenge for public health. About 30% DCM cases are genetic origin; however, large majority sporadic, viral or immune pathogenesis suspected. Following established postulates autoimmune diseases, here we provide direct evidence that an attack directed against cardiac β1-adrenergic receptor may play causal role DCM. First, immunized inbred rats second extracellular...
Background —Autoantibodies against synthetic peptides of β-adrenergic receptors have been observed in human cardiomyopathy. However, it has never shown that such antibodies really interact with native receptors, nor the clinical impact an interaction investigated larger groups patients. Methods and Results —We screened 104 patients dilated or ischemic cardiomyopathy (NYHA functional classes II to IV) 108 healthy subjects for IgG reacting β-receptor peptides. Such IgGs were further analyzed...
To evaluate the extent of intraarticular vascularization and pannus formation in metacarpophalangeal (MCP) proximal interphalangeal (PIP) joints patients with rheumatoid arthritis (RA) by high-resolution ultrasound (US).A newly developed, multidimensional linear array US was utilized to obtain longitudinal transverse scans active RA (n = 21), moderately 39), or inactive 93), from healthy controls 120).Healthy had no detectable pannus, whereas could be detected 52% RA, 82% 67% RA. There a...
Elevated plasma norepinephrine levels are associated with increased mortality in patients and animal models chronic heart failure. To test which alpha2-adrenoceptor subtypes operate as presynaptic inhibitory receptors to control release failure, we investigated the response of gene-targeted mice lacking (alpha2-KO) left ventricular pressure overload. In addition, determined functional consequences genetic variants alpha2-adrenoceptors human failure.Cardiac overload was induced by transverse...
Angiotensin II receptors play an essential role in cardiovascular physiology and disease. The significance of angiotensin type (AT 2 ) cardiac disease still remains elusive. Thus, we tested gene-targeted mice whether AT modulate function remodeling after experimental myocardial injury. To generate infarcts reproducible size, a cryolesion was generated at the free wall left ventricle wild-type ( Agtr2+/Y carrying deletion receptor gene Agtr2-/Y ). Postinjury followed up for 4 weeks...
Pituitary adenylate cyclase-activating polypeptide (PACAP), acting via 3 different G protein-coupled receptors, has been implicated in the regulation of several homeostatic systems body, including cardiopulmonary control. To define physiologic role PACAP-preferring type I receptor, PAC1, function, we developed a mutant mouse strain lacking functional PAC1 receptors.When PAC1-deficient mice were crossed onto C57BL/6 background, almost all mutants died during second postnatal week. Whereas...
Monocytes and macrophages are indispensable in the healing process after myocardial infarction (MI); however, spatiotemporal distribution of monocyte infiltration its correlation to prognostic indicators reperfused MI have not been well described.With combined fluorine 19/proton ((1)H) magnetic resonance imaging, we noninvasively visualized recruitment monocytes vivo a rat model MI. Blood were labeled by intravenous injection (19)F-perfluorocarbon emulsion 1 day The patterns correlated...
Myocarditis represents a major cause of dilated cardiomyopathy and sudden cardiac death in younger adults. Currently, definitive diagnosis myocarditis requires endomyocardial biopsy, which is highly invasive has the drawback variable sensitivity due to inherent sampling error. Therefore, reliable noninvasive methods detect monitor inflammation are clinically relevant. In this study, we explored potential radiolabeled methionine assess myocardial inflammatory activity rat model experimental...
Background: In the light of clinical controversy whether metallic stents or plastic endoprostheses should be used in percutaneous treatment biliary obstruction we retrospectively evaluated our experience with both drainage-systems.