A5101476541- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Polyomavirus and related diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- Cancer survivorship and care
- Ubiquitin and proteasome pathways
- Advanced Proteomics Techniques and Applications
- Herpesvirus Infections and Treatments
- Renal Transplantation Outcomes and Treatments
- Machine Learning in Bioinformatics
- CAR-T cell therapy research
Shandong University
2015-2025
Shandong Provincial Hospital
2016-2025
Wenzhou Medical University
2025
South China Agricultural University
2023-2025
Shandong First Medical University
2020-2024
Zhengzhou University
2023-2024
Nantong University
2024
Guangdong Medical College
2023
First Affiliated Hospital of Soochow University
2023
Tunghai University
2023
The incidence of non-Hodgkin's lymphoma (NHL) has increased steadily over the past few decades. Elucidating its global burden will facilitate more effective disease management and improve patient outcomes. We explored burden, risk factors, trends in mortality NHL globally.The up-to-date data on age-standardized rates were retrieved from GLOBOCAN 2020, CI5 volumes I-XI, WHO database, Global Burden Disease (GBD) 2019, focusing geographic disparities worldwide. reported by sex age, along with...
The glioblastoma (GBM) stem cell–like cells (GSCs) are critical for tumorigenesis/therapeutic resistance of GBM. Mounting evidence supports tumor-promoting function long noncoding RNAs (lncRNAs), but their role in GSCs remains poorly understood. By combining CRISPRi screen with orthogonal multiomics approaches, we identified a lncRNA DARS1-AS1 –controlled posttranscriptional circuitry that promoted the malignant properties GBM cells/GSCs. Depleting inhibited proliferation cells/GSCs and...
Klotho, is a transmembrane protein, performs as circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast factor (FGF), Wnt signaling pathways. These pathways are involved in development progression B cell lymphoma. We aimed to explore expression pattern functional mechanism Klotho diffuse large lymphoma (DLBCL). Immunohistochemistry (IHC) western blotting were performed detect level DLBCL patients lines. Tumor suppressive effect was...
The development of broad-spectrum universal influenza vaccines and optimisation vaccination strategies to address the threats posed by pandemics emerging viruses are critical for public health. In this study, an adenovirus type 5 vector-based vaccine carrying hemagglutinin (HA) stem H1, HA H3, neuraminidase N1 from virus was constructed. Immune responses were evaluated in mice using various strategies: prime-only (intramuscular [IM] or intranasal [IN]) prime-boost (IM+IN). Compared strategy,...
ABSTRACT The development of broad‐spectrum universal influenza vaccines and optimization vaccination strategies to address the threats posed by pandemics emerging viruses are critical for public health. In this study, an adenovirus type 5 vector‐based vaccine carrying hemagglutinin (HA) stem H1, HA H3, neuraminidase (NA) N1 from virus was constructed. Immune responses were evaluated in mice using various strategies: prime‐only (intramuscular [IM] or intranasal [IN]) prime‐boost (IM + IN)....
The multi-center randomized phase 3 NHL-004 study compared etoposide, dexamethasone and pegaspargase (ESA) versus methotrexate, (MESA) regimen, combined with sandwiched radiotherapy, in newly diagnosed early-stage nasal natural killer/T-cell lymphoma (NKTCL). Here we report the long-term outcomes (median follow-up, 64 months) biomarker analysis. 256 eligible patients aged 14-70 years were randomly assigned (1:1) to ESA or MESA arm. 5-year progression-free survival (PFS) rates 80.3% 74.9%...
Feline herpesvirus-1 (FHV-1) is a leading cause of feline viral rhinotracheitis (FVR), which mainly presents upper respiratory tract symptoms. Vaccination the most effective strategy for controlling FHV-1. Prior to initiation this study, China does not have domestically produced commercially available FHV-1 vaccines using field strain as antigenic component and corresponding imported contained rhinotracheitis, calicivirus, panleukopenia (FVRCP) antigens. However, protective efficacy these...
Canine influenza virus (CIV) is a respiratory pathogen that causes fever, coughing, and sneezing in dogs continuously circulating canine populations. Tetherin an antiviral host restriction factor mediated by interferon, capable of inhibiting the release enveloped viruses from infected cells. The mechanism tetherin mainly due to its unusual topology, which includes short N-terminal cytoplasmic tail (CT), transmembrane (TM) domain, coiled-coil extra-cellular region (CC), C-terminal...
SUMMARY The natural site of infection for T. gondii is the mucosal surface intestine, so protective immunity obtained after with points to importance developing a vaccine that stimulates defences. In this study, an aroA − and aroD attenuated strain Salmonella typhimurium (BRD509) has been used deliver recombinant eukaryotic plasmid pSAG 1‐2 /CTA 2 /B expressing multi‐antigenic gene encoding SAG1 SAG2 linked A subunits cholera toxin as candidate oral vaccine. Immunoblot analysis showed...
Up-regulation of heat shock protein 70 (HSP70) could be elicited primarily by in former studies, and this was proved to associated with cancer progression. Burkitt's lymphoma is one highly aggressive B-cell non-Hodgkin's the fastest growing human tumors. To investigate effect HSP70 expression on sensitivity Burkitt cells (Raji cells) chemotherapy its role involvement PI3K/AKT pathway, we evaluated effects LY294002, a PI3K inhibitor, cell adriamycin (ADM) or cisplatin (DDP). In present study,...
The site-modification network (SMNet) profiles that incorporate the relationship between different PTMs can significantly enhance performance of PTM site prediction.
Abstract Background Patients diagnosed as diffuse large B cell lymphoma (DLBCL) with CD5 positive normally have a worse outcome and poorly respond to the regulatory treatment strategy. Results We recently reported differently expressed tRFs their potential target-genes of in patients CD5+ R/R DLBCL. Differently were detected by Illumina NextSeq instrument results verified quantitative real-time reverse transcription-PCR. tRF2Cancer database was searched compared results. Further research...
The accurate estimation of the spatial and temporal distribution chlorophyll-a (Chl-a) concentrations in South China Sea (SCS) is crucial for understanding marine ecosystem dynamics water quality assessment. However, challenge missing values satellite-derived Chl-a data has hindered obtaining complete spatiotemporal information. Traditional methods deriving are based on modeling measured sensor situ measurements. Spatiotemporal imputation difficult due to inaccessibility Chl-a. In this...
The antitumor mechanisms of adriamycin (ADR) have been thought to contribute induction apoptosis and inefficiency DNA repair, processes that are a large extent mediated by mitochondria. This study aimed investigate characteristics ADR, including its antineoplastic activity, drug resistance, unexpected toxicity in non-Hodgkin lymphoma (NHL) Raji cells at the mitochondrial proteomic level. alterations proteome treated with ADR were analyzed two-dimensional differential in-gel electrophoresis...
TMED2 is a member of the transmembrane emp24 domain (Tmed)/p24 protein family, which significantly upregulated in breast cancer, ovarian cancer and other tumour tissues. The purpose this study was to investigate expression MM cell lines its effect on biological behaviour lines.Real-time quantitative PCR (RT-qPCR) used detect lines, including MM.1S RPMI 8226 cells, lentivirus vector-mediated gene silencing further downregulation viability, cycle, apoptosis.Based RT-qPCR results, mRNA...
Abstract Background This study aimed to evaluate the predictive value of systemic inflammation response index (SIRI) in primary gastrointestinal diffuse large B‐cell lymphoma (PGI‐DLBCL) patients and establish a highly discriminating risk prediction model. Methods retrospective analysis included 153 PGI‐DCBCL diagnosed between 2011 2021. These were divided into training set ( n = 102) validation 51). Univariate multivariate Cox regression analyses conducted examine significance variables on...
Radioresistance represents a major obstacle to successful outcome for the treatment of non-Hodgkins lymphoma (NHL). Here we performed global differential proteome analysis mitochondria in Raji cells exposed radiation. The results showed that 23 differentially expressed proteins were identified. Furthermore, GAPDH, RECQL4, MKI67, and ATAD3B could serve as potential biomarkers radioresistance. Keywords: Mitochondria, Comparative proteomics, Raji, Radiation, Biomarker
Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP)/CHOP-like chemotherapy is widely used in peripheral T cell lymphoma (PTCL). Here we conducted a phase 2, multicenter, randomized, controlled trial, comparing the efficacy safety of CEOP/IVE/GDP alternating regimen with CEOP newly diagnosed PTCL.
The aim of our study was to evaluate the clinical characteristics myelodysplastic syndrome (MDS) patients with concomitant mild-to-moderate myelofibrosis (MF), and assess its independent prognostic role in MDS diagnosed by World Health Organization 2016 classification (WHO2016C) long-term follow-up.A total 157 primary associated or without MF were examined retrospectively follow-up. graded as MF-1/MF-2 defined "mild/moderate". Cytogenetics testing fluorescence situ hybridization (FISH) also...