A5033207412- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Facial Trauma and Fracture Management
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Pectus Deformity Diagnosis and Treatment
- Dental Radiography and Imaging
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Cardiac Imaging and Diagnostics
- Facial Nerve Paralysis Treatment and Research
- Monoclonal and Polyclonal Antibodies Research
- Transplantation: Methods and Outcomes
- MRI in cancer diagnosis
First Affiliated Hospital of Xiamen University
2016-2025
Fujian Medical University
2023-2025
Second Military Medical University
2005-2024
Changhai Hospital
2005-2024
Fudan University
2024
Qingdao University
2004-2024
Affiliated Hospital of Qingdao University
2024
Shaanxi University of Chinese Medicine
2024
Xiamen University
2022-2023
Shanghai Jiao Tong University
2009-2023
Hepatitis B virus (HBV) reactivation is a serious complication for patients with lymphoma treated rituximab-containing chemotherapies, despite lamivudine prophylaxis treatment. An optimal prophylactic antiviral protocol has not been determined.To compare the efficacy of entecavir and in preventing HBV seropositive hepatitis surface antigen untreated diffuse large B-cell receiving chemotherapy treatment rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP).Randomized,...
Implantation failure remains a critical barrier to in vitro fertilization. Prednisone, as an immune-regulatory agent, is widely used improve the probability of implantation and pregnancy, although evidence for efficacy inadequate.To determine 10 mg prednisone compared with placebo on live birth among women recurrent failure.A double-blind, placebo-controlled, randomized clinical trial conducted at 8 fertility centers China. Eligible who had history 2 or more unsuccessful embryo transfer...
Abstract The cribriform‐morular variant (C‐MV), an unusual and peculiar subtype of papillary thyroid carcinoma (PTC), has been observed frequently in familial adenomatous polyposis (FAP)‐associated also sporadic carcinoma. In this paper, five young women with the C‐MV PTC, aged 22–34 years at cancer diagnosis, are reported; two them had attenuated FAP. Grossly, one FAP‐associated tumour were multicentric others solitary. Histologically, tumours encapsulated exhibited a combination...
Abstract MicroRNAs, a class of small noncoding RNAs, have been implicated to regulate gene expression in virtually all important biological processes. Although accumulating evidence demonstrates that miR-150, an regulator hematopoiesis, is deregulated various types hematopoietic malignancies, the precise mechanisms miR-150 action are largely unknown. In this study, we found downregulated samples from patients with acute lymphoblastic leukemia, myeloid and chronic normalized after achieved...
Abstract Nucleophosmin ( NPM1 ) is the most commonly mutated gene in acute myeloid leukemia (AML) resulting aberrant cytoplasmic translocation of encoded nucleolar protein (NPM1c + ). NPM1c maintains a unique leukemic expression program, characterized by activation HOXA / B clusters and MEIS1 oncogene to facilitate leukemogenesis. However, mechanisms which controls such patterns promote leukemogenesis remain largely unknown. Here, we show that HOXBLINC , HOXB locus-associated long non-coding...
Abstract Purpose: Leukemic stem cells (LSC) are responsible for leukemia initiation, relapse, and therapeutic resistance. Therefore, the development of novel approaches targeting LSCs is urgently needed patients with acute myeloid (AML). Experimental Design: The LSC-like cell lines (KG-1α Kasumi-1) CD34+ primary AML purified from (n = 23) treated CS055 and/or chiglitazar were analyzed viability, death, colony formation assay. We performed RNA sequencing, glutamate release, intracellular...
Abstract Background Psychosocial functioning is poor in patients with pectus excavatum (PE). However, a comprehensive understanding of this issue does not exist. The aim study was to assess the severity psychosocial problems as associated PE, well identify its risk factors. Methods A comparative performed at Sichuan Academy Medical Sciences/Sichuan Provincial People's Hospital Chengdu, China. Patients age 6 16 who admitted outpatient department for evaluation or treatment PE were included...
Delivery of bone marrow-derived mesenchymal stem cells (MSCs) to myocardium protects ischemic tissue through the paracrine release beneficial angiogenic and cytoprotective factors. Platelet-derived growth factor (PDGF)-BB, a potent mitogen MSCs, is involved in pathophysiology heart disease. However, role(s) PDGF MSC-mediated cardioprotection remains unknown. Here, we found that treatment MSCs resulted rapid activation both Akt ERK (central intracellular signal mediators), upregulated VEGF,...
Abstract Purpose: Tumor-infiltrating B lymphocytes (TIL-B) have demonstrated prognostic and predictive significance in solid cancers. In this study, we aimed to distinguish TIL-Bs from malignant B-cells diffuse large B-cell lymphoma (DLBCL) determine the clinical biological significance. Experimental Design: A total of 269 patients with de novo DLBCL International R-CHOP Consortium Program were studied. Ultra-deep sequencing immunoglobulin genes was performed clonotypes. The frequencies...
BACKGROUND: Serum tumor markers have not yet been developed for the clinical diagnosis and treatment of sinonasal inverted papilloma (SNIP), one most significant tumors. Therefore, this study aimed to determine diagnostic value serum squamous cell carcinoma antigen (SCCA) cytokeratin fragment 21-1 (CYFRA 21-1) SNIP. METHODS: Clinical data were obtained from 101, 56, 116 patients with SNIP, (SNSCC), unilateral chronic rhinosinusitis (CRS), respectively. Preoperative SCCA CYFRA levels...
In this study, we report the results of using fluorine deoxyglucose positron emission tomography/computed tomography (FDG PET/CT) to guide antifungal therapy against chronic disseminated candidiasis in patients with acute leukemia. Three adult were enrolled study. All underwent a series PET/CT scans during course therapy. Antifungal was modified based on change FDG activity known sites fungal infection. With guidance PET/CT, all 3 achieved favorable outcomes long-term follow-up. appeared be...
The difference between clinical characteristics and outcomes follicular lymphoma grade 1-2 (FL1-2) FL3a defined pathologically remains unclear, resulting in uncertainty how to treat FL3a. However, it may be crucial for clinicians discriminate 3a predicting prognosis thus making treatment decisions.
Acute myeloid leukemia (AML) is one of the most threatening hematological malignances. cGAS-STING pathway plays an important role in tumor immunity and development. However, prognostic AML remains unknown. Firstly, The expression cGAS STING was analyzed by bioinformatics analysis. Subsequently, Bone marrow samples were collected from 120 patients 15 healthy individuals independent cohort. significantly elevated compared with controls. Patients high had a higher NRAS/KRAS mutation rate lower...
The multi-center randomized phase 3 NHL-004 study compared etoposide, dexamethasone and pegaspargase (ESA) versus methotrexate, (MESA) regimen, combined with sandwiched radiotherapy, in newly diagnosed early-stage nasal natural killer/T-cell lymphoma (NKTCL). Here we report the long-term outcomes (median follow-up, 64 months) biomarker analysis. 256 eligible patients aged 14-70 years were randomly assigned (1:1) to ESA or MESA arm. 5-year progression-free survival (PFS) rates 80.3% 74.9%...
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis and bone destruction. In recent years, the role of Nrf2/Keap1 pathway in RA has received much attention. Research shown that plays an important regulating oxidative stress inflammatory response. Activation Nrf2 can alleviate inflammation destruction RA, while overexpression Keap1 may exacerbate symptoms. This article discusses research progress traditional Chinese medicine based on including its molecular...