A5100401145- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Advanced Electron Microscopy Techniques and Applications
- RNA Research and Splicing
- RNA modifications and cancer
- Liver Disease and Transplantation
- Electron and X-Ray Spectroscopy Techniques
- FOXO transcription factor regulation
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
- Medical Imaging Techniques and Applications
- Caveolin-1 and cellular processes
- Ubiquitin and proteasome pathways
- PARP inhibition in cancer therapy
Qinghai University
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Wenzhou Medical University
2025
Capital Medical University
2015-2024
Beijing Tian Tan Hospital
2014-2024
Xiangya Hospital Central South University
2024
Central South University
2024
Tianjin Huanhu Hospital
2015-2023
Tianjin Medical University
2023
Tianjin First Center Hospital
2023
Gliomas are the most common and malignant intracranial tumors in adults. Recent studies have revealed significance of functional genomics for glioma pathophysiological treatments. However, access to comprehensive genomic data analytical platforms is often limited. Here, we developed Chinese Glioma Genome Atlas (CGGA), a user-friendly portal storage interactive exploration cross-omics data, including nearly 2000 primary recurrent samples from cohort. Currently, open provided whole-exome...
Abstract Purpose: Glioma tissues consist of not only glioma cells but also glioma-associated nontumor cells, such as stromal and immune cells. These dilute the purity play important roles in biology. Currently, implications variation are sufficiently clarified. Experimental Design: Here, tumor was inferred for 2,249 gliomas 29 normal brain from 5 cohorts. Based on transcriptomic profiling method, we classified CGGA TCGA-RNAseq cohorts RNAseq set discovery. Cases TCGA-microarray, REMBRANDT,...
Abstract Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade gliomas. The O-6-methylguanine-DNA methyltransferase (MGMT) responsible direct repair main TMZ-induced toxic DNA adduct, O6-Methylguanine lesion. MGMT promoter hypermethylation currently only known biomarker TMZ response patients. Here we show that subset recurrent gliomas carries genomic rearrangements lead...
Abstract Aims This study aimed to investigate the role of plasmacytoma variant translocation 1 (PVT1), a long non‐coding RNA, in glioblastoma multiforme (GBM) and its impact on tumor microenvironment (TME). Methods We assessed aberrant PVT1 expression glioma tissues GBM cell growth vitro vivo. Additionally, we investigated PVT1's influencing glioma‐associated macrophages. To understand immunosuppressive TME, performed series comprehensive experiments. Results was overexpressed due copy...
Gliomas are the most common malignant tumors of brain. Immune checkpoints have been increasingly emphasized as targets for treating tumors. B7‐H3 has identified an immune checkpoint that shows potential value targeting therapies. We set out to characterize expression pattern and biological function in brain gliomas using high‐throughput data obtained from Chinese Glioma Genome Atlas (CGGA) Cancer (TCGA) projects. was upregulated more higher‐grade than lower‐grade both CGGA TCGA datasets....
// Ailiang Zeng 1 , Qi Hu Yanwei Liu 2 Zheng Wang Xiaoming Cui Rui Li Wei Yan Yongping You Department of Neurosurgery, The First Affiliated Hospital Nanjing Medical University, 210029, PR China Beijing Neurosurgical Institute, Capital 100050, Correspondence to: You, e-mail: yypl9@njmu.edu.cn Yan, neuro_yw@njmu.edu.cn Keywords: IDH1/2 mutation, Ki-67 labeling index, prognosis, glioma, molecular classification Received: March 24, 2015 Accepted: August 07, Published: 18, ABSTRACT current World...
Necrosis is a hallmark feature of glioblastoma (GBM). This study investigated the prognostic role necrotic patterns in GBM using fractal dimension (FD) and lacunarity analyses magnetic resonance imaging (MRI) data evaluated biological processes leading to necrosis. We retrospectively reviewed clinical MRI 95 patients with GBM. FD necrosis on were calculated by analysis subjected survival analysis. also performed gene ontology 32 available RNA-seq data. Univariate revealed that < 1.56 > 0.46...
Abstract Gliomas are the most common and malignant intracranial tumours in adults. Recent studies have shown that functional genomics greatly aids understanding of pathophysiology therapy glioma. However, comprehensive genomic data analysis platforms relatively limited. In this study, we developed Chinese Glioma Genome Atlas (CGGA, http://www.cgga.org.cn ), a user-friendly portal for storage interactive exploration multi-dimensional includes nearly 2,000 primary recurrent glioma samples from...
Immune response mediated by macrophages is critical in tumor progression and implicates new targets potential efficient immunotherapies.Tumor associated (TAM) are divided into either polarized M1 or M2 phenotype depending on different regulators of polarization pro-or anti-oncogenic roles they play.Glioma-infiltrated TAMs have been newly reported contrary to the current dogma.Instead, glioma exhibit a continuum between M1-and M2-like TAM that resembling M0 macrophage.Here we proposed an OS...
O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a conventional technique to predict the prognosis or individualized treatment of glioma in tumor tissue following surgery biopsy. However, cannot be applied those patients with concomitant neurological dysfunctions advanced age. The present study aimed find new minimally invasive and efficient alternative method for detection MGMT methylation. expression was assessed peripheral blood cerebrospinal fluid (CSF), compared...
Recent evidence has confirmed that a mutation of the isocitrate dehydrogenase (IDH) gene occurs early in gliomagenesis and contributes to suppressed immunity. The present study aimed determine candidate genes associated with IDH status could serve as biomarkers immune suppression for improved prognosis prediction. Clinical information RNA-seq expression data were collected 932 glioma samples from CGGA TCGA databases, differentially expressed both lower-grade (LGG) glioblastoma (GBM)...
Abstract As aldehyde dehydrogenase (ALDH) is a novel stem cell marker, increasing studies have confirmed that high ALDH activity promotes tumorigenesis and progression in cancers. Some preliminary found ALDH1A3 may play an important role glioma malignant progression, but so far there was no conclusive conclusion. The purpose of our study to elucidate the mechanisms by which regulated provide practical tools for clinical application. Aldefluor, flow cytometry sorting qRT-PCR were performed...
Metabolic reprogramming has been proposed to be a hallmark of cancer. Aside from the glycolytic pathway, metabolic changes cancer cells primarily involve amino acid metabolism. However, in glioma, characteristics metabolism‐related gene set have not systematically profiled. In present study, RNA sequencing expression data 309 patients Chinese Glioma Genome Atlas database were included as training set, while another 550 within The Cancer used validate. Consensus clustering samples yielded two...
Significance Genomic instability fuels tumor progression and treatment resistance in cancer. Causative factors means for clinical detection of genomic the bulk gliomas have been inadequately explored. We identify a conserved gene coexpression module centered on CDC20 (CDC20-M) glioma transcriptomes that encompasses broad activities cell proliferation genome maintenance. show high CDC20-M expression robustly predicts poor prognosis severe chromosomal mutation burden glioma. Core members...
Background Dysregulated receptor tyrosine kinases, such as the mesenchymal-epidermal transition factor (MET), have pivotal role in gliomas. MET and its interaction with tumor microenvironment been previously implicated secondary However, contribution of gene to cells’ ability escape immunosurveillance checkpoints primary gliomas, especially glioblastoma (GBM), which is a WHO grade 4 glioma worst overall survival, still poorly understood. Methods We investigated relationship between...
Summary Aims To explore the prognostic and clinicopathological features of glioma with Paxillin ( PXN ) expression based on a large number samples. Methods RNA sequencing data 325 samples from Chinese Glioma Genome Atlas CGGA database were obtained as discovery set. Three additional datasets further validation sets. The protein pattern in was measured by IHC . Kaplan–Meier survival multivariate Cox analysis used to estimate distributions. Moreover, functional annotation also analyzed....
Background: Immunotherapy provided unprecedented advances in the treatment of several previously untreated cancers. However, these immunomodulatory maneuvers showed limited response to patients with glioma clinical trials. Our aim was depict immune characteristics cytolytic activity at genetic and transcriptome levels. Methods: In total, 325 gliomas from CGGA dataset as training cohort 699 TCGA validation were enrolled our analysis. We calculated for thousands gliomas. The interpreted by...
Abstract Susceptibility-weighted imaging (SWI) can be a useful tool to depict vascular structures in brain tumors as well micro-bleedings, which represent tumor invasion blood vessels and could also representative of tumoral angiogenesis. In this study, we investigated the relationship between SWI features glioma grades, expression key molecular markers isocitrate dehydrogenase 1 ( IDH1 ), O-6-methylguanine-DNA methyltransferase MGMT 1p19q. The gliomas were graded according intratumoral...
Metagenomic next-generation sequencing (mNGS), mostly carried out in independent clinical laboratories, has been increasingly applied pathogen diagnosis. We aimed to explore the feasibility of mNGS laboratories and analyze its potential diagnosis infectious ascites. Two reference panels composed 12 strains commonly appearing peritonitis were constructed evaluate performance metrics based on in-house protocols. The detection value was analyzed 211 ascitic samples compared with culture...
Background: PD-1 plays a critical part in control of immune response to malignancy. Anti-PD-1 treatment is hopeful strategy improve the dismal prognosis gliomas. To characterize role diffuse gliomas, we investigated its related biological process at transcriptome level and clinical prognostic value. Method patients: Through Chinese Glioma Genome Atlas TCGA datasets, systematically reviewed total 994 cases with RNA-seq data analyzed functional annotation by Gene ontology (GO) analysis....
To investigate the relationship between tumor characteristics and preoperative counts of immune cells in peripheral blood test glioma patients.We included 260 WHO grades II-IV patients who had result from Sanbo hospital as training set. The 66 Tiantan was obtained for validation. RNA sequencing data CGGA TCGA datasets were used to evaluate features neutrophil subtype lymphocyte glioma.We revealed that count lymphocytes, eosinophils neutrophils associated with grades. Neutrophil-to-lymphocyte...
Patients with multiple organ metastases from hepatic alveolar echinococcosis have a high mortality rate. However, predictors of multi-organ metastasis not been identified. We aimed to develop nomogram that predicts in patients echinococcosis. retrospectively screened who were treated between January 2016 and December 2021 at Qinghai Provincial People's Hospital, China. The outcome the was collected patients' basic characteristics, disease course, imaging, blood laboratory results. Least...