A5010406647- Glioma Diagnosis and Treatment
- Mathematical Biology Tumor Growth
- Bioinformatics and Genomic Networks
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- RNA Research and Splicing
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Vascular Malformations Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Neurofibromatosis and Schwannoma Cases
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Bone health and treatments
- Meningioma and schwannoma management
- Nutrition, Genetics, and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
Beijing Institute of Neurosurgery
2018-2025
Capital Medical University
1999-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Beijing Tian Tan Hospital
2018-2024
National Clinical Research Center for Digestive Diseases
2019-2024
Hong Kong University of Science and Technology
2022-2023
University of Hong Kong
2022-2023
HKUST Shenzhen Research Institute
2023
University of Science and Technology Beijing
2023
Peking University
2022
Gliomas are the most common and malignant intracranial tumors in adults. Recent studies have revealed significance of functional genomics for glioma pathophysiological treatments. However, access to comprehensive genomic data analytical platforms is often limited. Here, we developed Chinese Glioma Genome Atlas (CGGA), a user-friendly portal storage interactive exploration cross-omics data, including nearly 2000 primary recurrent samples from cohort. Currently, open provided whole-exome...
N6-methyladenosine (m6A) RNA methylation, associated with cancer initiation and progression, is dynamically regulated by the m6A methylation regulators ("writers", "erasers" "readers"). Here, we demonstrate that most of thirteen main are differentially expressed among gliomas stratified different clinicopathological features in 904 gliomas. We identified two subgroups (RM1/2) applying consensus clustering to regulators. Compared RM1 subgroup, RM2 subgroup correlates a poorer prognosis,...
Abstract Background The prognosis for diffuse gliomas is very poor and the mechanism underlying their malignant progression remains unclear. Here, we aimed to elucidate role of RNA N 6,2′- O -dimethyladenosine (m 6 A) reader, YTH 6-methyladenosine binding protein 2 (YTHDF2), in regulating gliomas. Methods YTHDF2 mRNA levels functions were assessed using several independent datasets. Western blotting, quantitative polymerase chain reaction, immunohistochemistry used evaluate expression other...
Abstract Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight IDH primary GBMs and defined signature (NES) tumor. show that NES significantly associates with activation transcription factors regulate brain development, including MYBL2...
Objective: We aimed to summarize the clinicopathological characteristics and prognostic features of various molecular subtypes diffuse gliomas (DGs) in Chinese population. Methods: In total, 1,418 patients diagnosed with DG between 2011 2017 were classified into 5 according 2016 WHO classification central nervous system tumors. The IDH mutation status was determined by immunohistochemistry and/or DNA sequencing, 1p/19q codeletion detected fluorescence situ hybridization. median clinical...
Abstract Lipid metabolism reprogramming plays important role in cell growth, proliferation, angiogenesis and invasion cancers. However, the diverse lipid programmes prognostic value during glioma progression remain unclear. Here, metabolism‐related genes were profiled using RNA sequencing data from The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) database. Gene ontology (GO) gene set enrichment analysis (GSEA) found that glioblastoma (GBM) mainly exhibited of glycosphingolipid metabolic...
Abstract Due to the rare incidence of spinal cord astrocytomas, their molecular features remain unclear. Here, we characterized landscapes mutations in H3 K27M, isocitrate dehydrogenase 1 ( IDH1 ) R132H, BRAF V600E, and TERT promoter 83 diffuse astrocytic tumors. Among these samples, thirty-five patients had K27M mutation; this mutant could be observed histological grade II (40%), III IV (20%) astrocytomas. were absent 58 cases tested. The V600E mutation (7/57) was only H3-wildtype...
Abstract Gliomas are the most common and malignant intracranial tumours in adults. Recent studies have shown that functional genomics greatly aids understanding of pathophysiology therapy glioma. However, comprehensive genomic data analysis platforms relatively limited. In this study, we developed Chinese Glioma Genome Atlas (CGGA, http://www.cgga.org.cn ), a user-friendly portal for storage interactive exploration multi-dimensional includes nearly 2,000 primary recurrent glioma samples from...
O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma temozolomide therapy. Given that IDH status has critical effects on survival and epigenetic features glioblastoma, we aimed assess role MGMT in IDH-mutant glioblastoma.This study included 187 glioblastomas 173 for comparison. Kaplan-Meier curves multivariate Cox regression were predictive effects.Compared with glioblastomas, showed significantly...
The role of brain immune compartments in glioma evolution remains elusive. We profile cells microenvironment and the matched peripheral blood from 11 patients. Glioblastoma exhibits specific infiltration blood-originated monocytes expressing epidermal growth factor receptor (EGFR) ligands EREG AREG, coined as tumor-associated (TAMo). TAMo is mutually exclusive with EGFR alterations (p = 0.019), while co-occurring mesenchymal subtype 4.7 × 10−7) marking worse prognosis 0.004 0.032 two...
Abstract The prognosis for diffusely infiltrating gliomas at World Health Organization (WHO) grade 2–4 remains dismal due to their heterogeneity. rapid development of genome-wide molecular-profiling-associated studies has greatly promoted the accuracy glioma classification. Thus, latest version WHO classification central nervous system tumors published in 2021 incorporated more molecular biomarkers together with histological features diagnosis gliomas. Advanced usage pathology clinical...
Abstract H3 K27‐altered diffuse midline glioma is a highly lethal pediatric‐type tumor without efficacious treatments. Recent findings have highlighted the heterogeneity among gliomas with different locations and ages. Compared to tumors located in brain stem thalamus, molecular clinicopathological features of spinal cord are still largely elusive, thus hindering accurate management patients. Here we aimed characterize K27M‐mutant 77 consecutive cases. We found that glioma, median age 35...
Abstract Pre-surgery differential diagnosis is valuable for personalized treatment planning in intramedullary spinal cord tumors. This study assessed the performance of sequencing cell-free DNA (cfDNA) cerebrospinal fluid (CSF) these Prospectively enrolling 45 patients with lesions, including diffuse midline glioma (DMG), H3K27-altered (14/45), glioblastoma (1/45), H3-wildtype-astrocytoma (10/45), ependymoma (11/45), and other lesions (9/45), CSF samples were collected via lumbar puncture...
Abstract 1p/19q codeletion, which leads to the abnormal expression of 1p19q genes in oligodendroglioma, is associated with chemosensitivity and favorable prognosis. Here, we aimed explore clinical implications gene non-codel gliomas. We analyzed 668 gliomas obtained from The Cancer Genome Atlas (n = 447) Chinese Glioma 221) for training validation, respectively. was significantly correlated clinicopathological features overall survival Then, derived a risk signature 25 selected that not only...
Now, numerous exciting findings have been yielded in the field of energy metabolism within glioma cells. In addition to aerobic glycolysis, multiple catabolic pathways are employed for production. However, prognostic significance remains obscure. Here, we explored relationship between gene profile and outcome diffuse patients using The Cancer Genome Altas (TCGA) Chinese Glioma (CGGA) datasets. Based on expression profile, consensus clustering identified two robust clusters with distinguished...
Transcriptomic data derived from bulk sequencing have been applied to delineate the tumor microenvironment (TME) and define immune subtypes in various cancers, which may facilitate design of immunotherapy treatment strategies. We herein gathered published gene expression diffuse lower-grade glioma (LGG) patients identify subtypes. Based on profiles 402 LGG The Cancer Genome Atlas, we performed consensus clustering determine robust clusters patients, evaluated their reproducibility three...
Isocitrate dehydrogenase (IDH) wild-type diffuse lower-grade glioma (LGG) is usually associated with poor outcome, but there have been disputes over its clinical outcome and classification. We present here a robust gene expression-based molecular classification of IDH LGG into two subtypes distinct biological features. A discovery cohort 49 LGGs from the Chinese Glioma Genome Atlas (CGGA) was subjected to clustering function analysis. Seventy-three tumors The Cancer (TCGA) were used validate...
Metabolic reprogramming has been proposed to be a hallmark of cancer. Aside from the glycolytic pathway, metabolic changes cancer cells primarily involve amino acid metabolism. However, in glioma, characteristics metabolism‐related gene set have not systematically profiled. In present study, RNA sequencing expression data 309 patients Chinese Glioma Genome Atlas database were included as training set, while another 550 within The Cancer used validate. Consensus clustering samples yielded two...
Clonal evolution drives cancer progression and therapeutic resistance. Recent studies have revealed divergent longitudinal trajectories in gliomas, but early molecular features steering posttreatment remain unclear. Here, we collected sequencing clinical data of initial-recurrent tumor pairs from 544 adult diffuse gliomas performed multivariate analysis to identify predictors three glioma subtypes. We found that CDKN2A deletion at initial diagnosis preceded necrosis microvascular...
Increasing evidence has shown that long non-coding RNAs (lncRNAs) are important prognostic biomarkers and epigenetic regulators with critical roles in cancer initiation progression. However, the expression clinical value of antisense lncRNAs diffuse glioma patients remain unknown. Here, we profiled differentially expressed using RNA sequencing data from Chinese Glioma Genome Atlas database. Cox regression was performed to evaluate value. Gene oncology (GO) gene set enrichment analysis (GSEA)...