A5084155930- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Nanoplatforms for cancer theranostics
- Bone Tumor Diagnosis and Treatments
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Terahertz technology and applications
- Sarcoma Diagnosis and Treatment
- Gene expression and cancer classification
- Pulmonary Hypertension Research and Treatments
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Cancer Cells and Metastasis
- interferon and immune responses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Extracellular vesicles in disease
Beijing Institute of Neurosurgery
2014-2025
Beijing Tian Tan Hospital
2015-2025
Capital Medical University
2015-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Hebei General Hospital
2024
Mianyang Central Hospital
2024
University of Electronic Science and Technology of China
2024
West China Medical Center of Sichuan University
2024
West China Hospital of Sichuan University
2018-2022
Sichuan University
2018-2022
Programmed cell death ligand 1 (PDL1, also known as B7H1) is a cell-surface protein that suppresses the cytotoxic CD8(+) T-cell-mediated immune response. PDL1 expression and its clinical relevance in sarcomas are not well understood. Therefore, we sought to measure RNA levels for 38 clinically annotated osteosarcoma tumor samples aimed determine if correlates with features tumor-infiltrating lymphocytes (TIL). Quantitative real-time RT-PCR was optimized 18 lines, of which 5 were derived....
// Pei Yang 1, 2, * , Wei Zhang Yinyan Wang 2 Xiaoxia Peng 3 Baoshi Chen Xiaoguang Qiu 4 Guilin Li 6 Shouwei 7 Chenxing Wu Kun Yao 8 Wenbin 9 Yan 10 Jie 11 Yongping You Clark C. Tao Jiang 5 1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China Department of Neurosurgery, Tiantan Hospital, Epidemiology and Biostatistics, School Public Health Family Medicine, Radiation Therapy, National Clinical Research Center for Neurological Diseases, Neuropathology, Sanbo Brain...
Grade II and III gliomas have variable clinical behaviors, showing the distinct molecular genetic alterations from glioblastoma (GBM), many of which eventually transform into more aggressive tumors. Since classifications grade II/III based on been recently emerging, it is now a trend to include data standard diagnostic algorithm glioma.Here we sequenced TERT promoter mutational status (TERTp-mut) in DNA 377 analyzed factors, aberrations, transcriptome profiles.We found that TERTp-mut...
// Jinquan Cai 1,5,* , Pei Yang 2,4,5,* Chuanbao Zhang Wei Yanwei Liu 2,4,5 Zhaoshi Bao Xing 1,5 Wenzhong Du Hongjun Wang ,Tao Jiang 2,3,4,5 and Chuanlu 1 Department of Neurosurgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Beijing Neurosurgical Institute, Capital University ,Beijing, 3 Institute for Brain Disorders Tumor Center 4 Tiantan Hospital, Beijing, 5 Chinese Glioma Cooperative Group (CGCG), * These authors contributed equally to the work...
Background Glioblastomas (GBM) are comprised of a heterogeneous population tumor cells, immune and extracellular matrix. Interactions among these different cell types pro-/anti-inflammatory cytokines may promote development progression. Aims The objective this study was to develop cytokine-related gene signature improve outcome prediction for patients with primary GBM. Methods Here, we used Cox regression risk-score analysis in GBMs from the whole transcriptome sequencing profile Chinese...
// Jinquan Cai 1, 7, * , Ping Zhu 4, Chuanbao Zhang 2, 3, Qingbin Li 7 Zhiliang Wang Guanzhang Guangzhi Pei Yang Jianlong Bo Han Chuanlu Jiang Ying Sun Tao 5, 6, 1 Department of Neurosurgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Beijing Neurosurgical Institute, Capital Beijing, 3 Tiantan Hospital, 4 Otolaryngology, Union Tongji College, Huazhong University Science and Technology, Wuhan, 5 Institute for Brain Disorders Tumor Center, 6 National Clinical...
// Wei Yan 1,2,* , Rui Li 2,* Yanwei Liu 1,4,* Pei Yang 1,4 Zheng Wang Chuanbao Zhang Zhaoshi Bao Yongping You 2 and Tao Jiang 1,3,4 1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China Department of Neurosurgery, First Affiliated Hospital Nanjing Nanjing, 3 Institute for Brain Disorders Tumor Center, 4 Tiantan Hospital, * These authors contributed equally to this work Correspondence: Jiang, email: You, Keywords : Anaplastic Gliomas; Secondary Glioblastomas;...
// Jinquan Cai 1, 6, * , Jing Chen 2, Wei Zhang 4, 6 Pei Yang Chuanbao Mingyang Li Kun Yao 7 Hongjun Wang Qingbin Chuanlu Jiang Tao 3, 5, 1 Department of Neurosurgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Beijing Neurosurgical Institute, Capital Beijing, 3 Institute for Brain Disorders Tumor Center, 4 Tiantan Hospital, 5 National Clinical Research Center Neurological Diseases, Chinese Glioma Cooperative Group (CGCG), Pathology, Sanbo These authors have...
// Rui Li 1,* , Hailin Wei Yan 1 Pei Yang 2,4 Zhaoshi Bao Chuanbao Zhang Tao Jiang 2,3,4 and Yongping You Department of Neurosurgery, The First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Beijing Neurosurgical Institute, Capital Beijing, 3 Institute for Brain Disorders, Tumor Center, 4 Tiantan Hospital, * These authors have contributed equally to this work Correspondence to: You, email: Keywords : Primary glioblastomas, Secondary Molecular subtypes, Whole transcriptome...
The major limitation to the success of chemotherapy in osteosarcoma is development multidrug resistance (MDR). Preventing emergence MDR during treatment has been a high priority clinical and investigational oncology, but it remains an elusive goal. NSC23925 recently identified as novel potent reversal agent. However, whether can prevent cancer unknown. Therefore, this study aims evaluate effects on prevention osteosarcoma. Human cell lines U-2OS Saos were exposed increasing concentrations...
ABSTRACT Reliable prognostic biomarkers for chordoma have not yet been established. Recent studies revealed that expression of miRNA‐1 (miR‐1) is frequently downregulated in several cancer types including chordoma. The goal this follow‐up study to investigate the miR‐1 as a biomarker and further confirm functional role cell growth proliferation. We determined relative levels Met tissue samples correlated those clinical variables. results showed was 93.7% tissues inversely with expression....
ABSTRACT Recent studies have revealed that expression of miRNA‐1 (miR‐1) is frequently down‐regulated in several cancer types including chordoma. Identifying and validating novel targets miR‐1 useful for understanding the roles We aimed to further investigate functions Specifically, we assessed whether restoration affects cell migration invasion chordoma, focused on potential target Slug gene. Migratory invasive activities were by wound healing Matrigel assays, respectively. Cell...
Background and purpose: Seizures are a common symptom of patients with primary brain tumors, particularly low‐grade gliomas (LGGs). Poor seizure control after surgery has great adverse impact on quality life in these patients. The present study aimed to identify clinical molecular genetic factors that influence postoperative control. Methods: A series 183 LGGs were analyzed by denaturing high‐performance liquid chromatography (DHPLC) for 1p 19q status immunohistochemical staining expression...
// Chuan-Bao Zhang 1, 2, 3, 4, * , Ping Zhu 5, Pei Yang 4 Jin-Quan Cai 6 Zhi-Liang Wang Qing-Bin Li Zhao-Shi Bao Wei Tao Jiang 1 Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China 2 Neurosurgery, Tiantan Hospital, 3 Center Brain Tumor, Institute for Disorders, National Clinical Research Neurological Diseases, 5 Otolaryngology, Union Tongji College, Huazhong University Science and Technology, Wuhan, The Second Affiliated...
// Eiji Osaka 1, 2 , Andrew D. Kelly 3 Dimitrios Spentzos 4 Edwin Choy 1 Xiaoqian Yang Jacson K. Shen Pei Henry J. Mankin Francis Hornicek Zhenfeng Duan Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA Nihon University School Medicine, Tokyo 173–8610, Japan Fels Institute for Cancer Research & Molecular Biology, Temple Philadelphia, PA 19140, Division Hematology/Oncology, Program, Beth Israel Deaconess Medical Center, 02215,...
Aldehyde dehydrogenases (ALDH) is a family of enzymes including 19 members. For now, ALDH activity had been wildly used as marker cancer stem cells (CSCs). But biological functions relevant isoforms and their clinical applications are still controversial. Here, we investigate the significance potential function ALDH1A3 in gliomas. By whole-genome transcriptome microarray mRNA sequencing analysis, compared expression high- low- grade gliomas well different molecular subtypes. Microarray...
Accumulating evidence has revealed that survivin expression is associated with a malignant phenotype and poor prognosis in glioma. Survivin also potential target of microRNA (miRNA/miR)‑218. The aim the present study was to investigate function glioblastoma, examine association between miR‑218. For purpose, mRNA levels were analyzed 144 frozen samples glioblastoma using whole‑genome RNA sequencing. In vitro cell proliferation, migration, invasion apoptosis assays performed, detected by...
Esophageal neuroendocrine carcinoma (ENEC) is an uncommon and highly aggressive tumor with obscure etiology. Thus, this study aimed to investigate the best treatment option for patients ENEC. This identified ENEC from Surveillance, Epidemiology, End Results (SEER) database between 1975 2021. Clinicopathological characteristics were analyzed using descriptive statistics, prognostic factors determined through Cox regression analysis. Kaplan-Meier survival analysis was used assess five-year...