A5100333274- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA modifications and cancer
- Circular RNAs in diseases
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Chemokine receptors and signaling
- Bone and Dental Protein Studies
- Cancer Research and Treatments
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Prostate Cancer Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Polyamine Metabolism and Applications
Zhengzhou University
2021-2025
Cleveland Clinic Lerner College of Medicine
2019-2025
Gansu Agricultural University
2025
Yuhuangding Hospital
2024
Qingdao University
2024
Wuhan University of Science and Technology
2024
Shanghai Jiao Tong University
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
Ruijin Hospital
2024
Exosomes are emerging as important mediators of the cross-talk between tumor cells and microenvironment. However, mechanisms by which exosomes modulate development under hypoxia in pancreatic cancer remain largely unknown. Here, we found that hypoxic derived from activate macrophages to M2 phenotype a HIF1a or HIF2a-dependent manner, then facilitates migration, invasion, epithelial-mesenchymal transition cells. Given have been shown transport miRNAs alter cellular functions, discovered...
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive tumors all over world, has a generally poor prognosis, and its progression is positively correlated with density blood vessels. Recently, tumor-associated macrophages (TAMs) were proven to be beneficial for angiogenesis, but their mechanism action remains unclear. Our study indicated that M2 microvessel (MVD) PDAC tissues, macrophage-derived exosomes (MDEs) could promote angiogenesis mouse aortic endothelial cells (MAECs) in...
Exosomes derived from mesenchymal stem cells (MSCs) have been proven to exhibit great potentials in spinal cord injury (SCI) therapy. However, conventional two-dimensional (2D) culture will inevitably lead the loss of stemness MSCs, which substantially limits therapeutic potency MSCs exosomes (2D-Exo). three-dimensional (3D-Exo) possess higher efficiency wide applications Typically, exosome therapy that relies on local repeated injection results secondary and low efficiency. It is urgent...
Tafamidis improved survival and decreased cardiovascular hospitalizations in the ATTR-ACT trial. Due to recognition earlier diagnosis, epidemiology of transthyretin amyloid cardiomyopathy (ATTR-CM) is rapidly evolving. The authors sought evaluate contemporary long-term outcomes patients with ATTR-CM treated tafamidis. Patients who received at least 1 dose tafamidis between 2018 2021 5 amyloidosis centers United States were enrolled. Primary outcome was all-cause mortality. Among 624...
Sepsis-associated liver dysfunction (SALD) aggravates the disease progression and prognosis of patients. Macrophages in play a crucial role occurrence development SALD. Human umbilical cord mesenchymal stem cells (MSCs), by secreting extracellular vesicles (EVs), show beneficial effects various inflammatory diseases. However, whether MSC-derived EVs (MSC-EVs) could ameliorate response macrophages underlying mechanisms remain unclear. In this study, mouse model sepsis induced...
Background Glioblastomas (GBM) are comprised of a heterogeneous population tumor cells, immune and extracellular matrix. Interactions among these different cell types pro-/anti-inflammatory cytokines may promote development progression. Aims The objective this study was to develop cytokine-related gene signature improve outcome prediction for patients with primary GBM. Methods Here, we used Cox regression risk-score analysis in GBMs from the whole transcriptome sequencing profile Chinese...
Long non-coding RNA (lncRNA) LINC00173 has been previously shown to promote chemoresistance and progression of small-cell lung cancer. Herein, we examine the clinical significance biological function in triple-negative breast cancer (TNBC). Quantitative PCR analysis was performed determine expression TNBC adjacent tissues (n = 84). The associations with features survival patients were analyzed. cell proliferation, colony formation, invasion explored. TNBCs expressed increased levels relative...
Abstract Background Human glutamic acid decarboxylase 65 (hGAD65) is a key autoantigen in type 1 diabetes, having much potential as an important marker for the prediction and diagnosis of development novel antigen-specific therapies treatment diabetes. However, recombinant production hGAD65 using conventional bacterial or mammalian cell culture-based expression systems nuclear transformed plants limited by low yield efficiency. Chloroplast transformation unicellular eukaryotic alga...
New chemotherapeutic strategy should be investigated to enhance clinical management in human gliomas. Recently, ursolic acid (UA), as a naturally occurring pentacyclic triterpene, has exhibited potent anticancer activity various tumour cells but remains uncertain glioma cells. Here, we examined whether UA could suppress the proliferation of cell line U251, and if so, its possible molecular targets. Cell survival, apoptosis targets were identified by multiple detecting techniques, including...
Oral squamous cell carcinoma (OSCC), the subtype of head and neck cancers, is notorious for its high incidence death rate. The role long non-coding RNAs (lncRNAs) discovered to be significant canceration cancer progression. Long intergenic non-protein coding RNA 958 (LINC00958) as a carcinogene in multiple such gastric cancer, pancreatic glioma, but there has been no report about how LINC00958 functions OSCC. objective our study unfold function mechanism investigation on First, TCGA database...
Cisplatin is the major chemotherapeutic drug in gastric cancer, particularly treating advanced cancer. Tumour cells often develop resistance to drugs, which seriously affects efficacy of chemotherapy. GPR30 a novel oestrogen receptor that involved invasion, metastasis and many tumours. Targeting has been shown increase sensitivity breast cancer cells. However, few studies have investigated role Epithelial-mesenchymal transition (EMT) be associated with development resistance. In this study,...
Platinum-based cytotoxic chemotherapy is considered the standard treatment for advanced gastric cancer (GC). However, cisplatin chemoresistance often occurs with mechanisms being not well clarified, which results in recurrence and poor survival. Ginsenoside Rg3, isolated from Chinese Herb Panax Ginseng, recognized as an anti-cancer agent. Herein, we aimed to reveal whether Rg3 alleviates resistance sensitizes GC cells cisplatin-induced apoptosis, draw out underlying molecular mechanism...
// Xing Liu 1, 3, * , Xiaofeng Wang Wenzhong Du Lingchao Chen 2 Guangzhi 3 Yuqiong Cui Yang Zhijin Dou Hongjun Ping Zhang Liang Chang Liye Yi Jinquan Cai Chuanlu Jiang 1 Department of Neurosurgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China Huashan Hospital, Fudan Shanghai, Chinese Glioma Cooperation Group (CGCG) These authors contributed equally to this work Correspondence to: Jiang, e-mail: jcl6688@163.com Chen, chenlingchao12@sina.com Keywords: glioma, Sufu,...
In the current study, we showed that combination of mammalian target rapamycin (mTOR) inhibitor RAD001 (everolimus) and Akt MK-2206 exerted synergistic cytotoxic effects against low-phosphatase tensin homolog (PTEN) gastric cancer cells (HGC-27 SNU-601 lines). HGC-27 cells, synergistically induced G1/S cell cycle arrest, growth inhibition, death but not apoptosis. light chain 3B (LC3B) beclin-1 expression, two important autophagy indicators. Meanwhile, 3-methyladenine (3-MA) chloroquine...
Previous studies indicate that TGFBR3 (transforming growth factor type III receptor, also known as betaglycan), a novel suppressor of progression in certain cancers, is down-regulated tongue squamous cell carcinoma (TSCC). However, the role this an upstream regulator TSCC cells remains to be elucidated. The present study was designed elucidate whether gene expression regulated by two microRNA molecules, miR-19a and miR-424. aimed determine if these microRNAs promote migration CAL-27 human...
Accumulating data show that prolylisomerase (Pin1) is overexpressed in human glioblastoma multiforme (GBM) specimens. Therefore, Pin1 inhibitors should be investigated as a new chemotherapeutic drug may enhance the clinical management of gliomas. Recently, juglone, inhibitor, was shown to exhibit potent anticancer activity various tumor cells, but its role glioma cells remains unknown. In present study, we determined if juglone exerts antitumor effects U251 cell line and potential underlying...
Long non-coding RNAs (lncRNAs) have been proposed as potential targets in OSCC gene therapy. Thus, the study aims to analyze how they exert functions OSCC. LINC00958, AIM2, Gasdermin D (GSDMD) and tumor protein p53 (TP53) expression levels are analyzed by Quantitative Real-time PCR (qPCR) or Western blotting (WB) cells lines. The roles of LINC00958 cell proliferation, death, GSDMD respectively were Cell Counting Kit-8 (CCK8) assay, flow cytometry Immunofluorescence (IF) assay. In addition,...