A5007146453- Bone health and osteoporosis research
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Immune Cell Function and Interaction
- Neuroendocrine Tumor Research Advances
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Nerve injury and regeneration
- RNA Interference and Gene Delivery
- PI3K/AKT/mTOR signaling in cancer
- Heat shock proteins research
- Traditional Chinese Medicine Studies
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
First Affiliated Hospital of Zhengzhou University
2016-2025
Qujiang People's Hospital
2021-2024
People's Hospital of Yangzhong
2019-2024
Southern Medical University
2016-2023
State Administration of Traditional Chinese Medicine of the People's Republic of China
2022-2023
Shanxi University
2021-2023
Liaoning University of Traditional Chinese Medicine
2021-2023
Zhengzhou People's Hospital
2017-2023
First Affiliated Hospital of Henan University
2023
Nanfang Hospital
2018-2022
The treatment of a brain glioma remains one the most difficult challenges in oncology. In present study delivery system was developed for targeted drug across blood‑brain barrier (BBB) to cancer cells. A cyclic arginine‑glycine‑aspartic acid (RGD) peptide and transferrin (TF) were utilized as targeting ligands. Cyclic RGD peptides are specific ligands cells TFs that specifically target BBB Liposome (LP) used conjugate establish cascade (RGD/TF‑LP). LPs prepared by thin film hydration method...
Taletrectinib, a highly potent, CNS-active,
// Benling Xu 1,2,* , Long Yuan 3,* Quanli Gao 2 Peng Zhao 4 Huijuan 5 Huijie Fan 1 Tiepeng Li Qin Lu Han Weijia Fang and Zhenhe Suo 1,6 Department of Oncology, The First Affiliated Hospital Zhengzhou University, Zhengzhou, Henan, P. R. China Cancer Biotherapy, 3 Surgery, Zhejiang Hangzhou, Zhejiang, Endocrinology, Henan Provincial People's Hospital, 6 Pathology, Oslo University Clinical Institute, Faculty Medicine, Oslo, Norway * These authors have contributed equally to the work...
Long non-coding RNA (lncRNA) LINC00173 has been previously shown to promote chemoresistance and progression of small-cell lung cancer. Herein, we examine the clinical significance biological function in triple-negative breast cancer (TNBC). Quantitative PCR analysis was performed determine expression TNBC adjacent tissues (n = 84). The associations with features survival patients were analyzed. cell proliferation, colony formation, invasion explored. TNBCs expressed increased levels relative...
Panax ginseng Meyer (P. ginseng), a herb distributed in Korea, China and Japan, exerts benefits on diverse inflammatory conditions. However, the underlying mechanism active ingredients remains largely unclear. Herein, we aimed to explore of P. against inflammation elucidate mechanisms.Inflammation model was constructed by lipopolysaccharide (LPS) C57BL/6 mice RAW264.7 macrophages. Molecular docking, molecular dynamics, surface plasmon resonance imaging (SPRi) immunofluorescence were utilized...
Vascular smooth muscle cell (VSMC) proliferation and migration play a critical role in the development of arterial remodeling during various vascular diseases including atherosclerosis, hypertension, related diseases. Luteolin is food-derived flavonoid that exerts protective effects on cardiovascular Here, we investigated mechanism luteolin VSMC migration. We found this compound reduced VSMCs, specifically A7r5 HASMC, dose-dependent manner, based MTS, EdU, Transwell, wound healing assays....
Abstract Megakaryocytic leukemia 1 (MKL1) is a key transcription factor involved in non-small cell lung cancer (NSCLC) growth and metastasis. Yet, its downstream target genes, especially long non-coding RNA (lncRNA) targets, are poorly investigated. In this study, we employed lncRNA array technology to identify differentially expressed lncRNAs NSCLC cells with or without overexpression of MKL1. Candidate were further explored for their clinical significance function NSCLC. The results showed...
Platinum-based cytotoxic chemotherapy is considered the standard treatment for advanced gastric cancer (GC). However, cisplatin chemoresistance often occurs with mechanisms being not well clarified, which results in recurrence and poor survival. Ginsenoside Rg3, isolated from Chinese Herb Panax Ginseng, recognized as an anti-cancer agent. Herein, we aimed to reveal whether Rg3 alleviates resistance sensitizes GC cells cisplatin-induced apoptosis, draw out underlying molecular mechanism...
Ferroptosis, a new regulated cell death pathway, plays crucial part in the development of cardiovascular disease. However, precise underlying mechanism remains unclear. Therefore, this study aimed to elucidate this.Herein, an erastin-induced H9C2 ferroptosis vitro model and myocardial infarction murine model, which was created by ligating left anterior descending coronary artery, were established. Ferroptosis-related indicators, injury-related Nrf2 signaling-related proteins expression...
Background: Aldehyde dehydrogenase-2 (ALDH2) has a protective effect on ischemic heart disease. Here, we examined the effects of ALDH2 cardiac fibrosis through modulation Wnt/ß-catenin signaling pathway in rat model myocardial infarction (MI). Methods: Wistar rats were divided into sham (control), MI (model), and activator (Alda-1) groups. After 10 days treatment, left ventricular (LV) remodeling parameters each animal evaluated by echocardiography. Myocardial was Masson's trichrome staining...
Cardiovascular disease, a disease caused by many pathogenic factors, is one of the most common causes death worldwide, and oxidative stress plays major role in its pathophysiology. Tanshinone I (Tan I), natural compound with cardiovascular protective effects, main active compounds extracted from Salvia miltiorrhiza . Here, we investigated whether Tan could attenuate stress–induced cardiomyocyte apoptosis through Nrf2/MAPK signaling vivo vitro We found that treatment protected cardiomyocytes...
Panax ginseng has therapeutic effects on various inflammation-related diseases. Ginsenoside Rb3 (GRb3), a natural compound with anti-inflammatory and immunomodulatory properties, is one of the main active panaxadiol extracted from . We explored whether GRb3 inhibited LPS-mediated inflammation through TLR4/NF-κB/MAPK signaling in macrophages. attenuated NO PGE 2 production by attenuating iNOS COX2 expression. also suppressed pro-inflammatory cytokines levels, including IL-1β, IL-6, TNF-α....
Abstract For developing gene therapy for chronic myelogenous leukemia (CML), we evaluated the feasibility of using autologous bone marrow stromal cells (BMSCs) one CML patient as a target cell population and studied efficiency recombinant adenovirus‐mediated human Gamma Interferon (hIFN‐γ) transfer into BMSCs. BMSCs can be readily obtained, expanded, successfully transduced with adenoviral vectors in vitro . We expression hIFN‐γ following transduction Ad/hIFN‐γ. On at MOI 50, secretion were...
Ribosomal protein L34 (RPL34) belongs to the L34E family of ribosomal proteins and contains a zinc finger motif. Aberrant expression RPL34 has been reported in several human malignancies. However, precise role potential underlying mechanisms esophageal cancer remain largely unknown. Thus, objective this study was investigate progression. Our results showed that at both mRNA levels frequently upregulated cell lines. Knockdown efficiently inhibited proliferation, migration, invasion vitro....
PURPOSE Taletrectinib is an oral, potent, CNS-active, selective, next-generation ROS1 tyrosine kinase inhibitor (TKI). We report integrated efficacy and safety from registrational taletrectinib studies in + non–small cell lung cancer. METHODS TRUST-I TRUST-II were phase II, single-arm, open-label, nonrandomized, multicenter trials. Efficacy outcomes pooled pivotal cohorts. The population comprised all patients treated with once-daily oral 600 mg across the clinical program. primary end point...