A5001009002- Reproductive System and Pregnancy
- Infant Nutrition and Health
- Pregnancy and Medication Impact
- Immune cells in cancer
- Inflammation biomarkers and pathways
- Congenital Diaphragmatic Hernia Studies
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- Tryptophan and brain disorders
- Macrophage Migration Inhibitory Factor
- Pregnancy and preeclampsia studies
- Dietary Effects on Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Preterm Birth and Chorioamnionitis
- Mesenchymal stem cell research
Southern Medical University
2021-2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Intestinal trefoil factor 3 (TFF3) plays an important role in repairing the intestinal mucosa. However, detailed mechanism regarding immune regulation by TFF3 is not well defined. Here, we reported that treatment of mouse BM cells and human peripheral blood mononuclear from healthy volunteers with activated polymorphnuclear myeloid-derived suppressor (PMN-MDSCs) vitro. We also found prostaglandin E2 a major TFF3-mediated MDSC target, NF-κB/COX2 signaling was involved this process. Moreover,...
The endothelin-A receptor antagonist BQ123 is an effective treatment agent for hypertension and obese cardiomyopathy. However, the role of in controlling acute inflammatory diseases its underlying mechanisms are not well understood. Here, we showed that activated polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) mice IL13/STAT6/Arg1 signaling pathway involved this process. Importantly, both with transfer BQ123-induced PMN-MDSCs (BQ123-MDSCs) were relieving inflammation,...
Abstract Elimination of the posttraumatic inflammatory response and recovery homeostasis are crucial for positive prognosis trauma patients. Myeloid-derived suppressor cells (MDSCs) known to play a regulatory role in immune mice, but their induction source involved potential mechanism poorly understood. Here, we report that polymorphonuclear MDSCs (PMN-MDSCs) activated after closely associated with progression response. In humans, lectin-type oxidized LDL receptor 1 (LOX1) was used...