A5020950137- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Congenital Diaphragmatic Hernia Studies
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Meta-analysis and systematic reviews
- Ophthalmology and Eye Disorders
- Ginseng Biological Effects and Applications
- Neural Networks and Applications
- Gut microbiota and health
- RNA regulation and disease
- Nosocomial Infections in ICU
- Plant Stress Responses and Tolerance
- Surface Modification and Superhydrophobicity
- Heavy Metals in Plants
- Postharvest Quality and Shelf Life Management
- Image and Signal Denoising Methods
- Plant tissue culture and regeneration
- Cancer, Lipids, and Metabolism
- Fluorine in Organic Chemistry
- Evaluation Methods in Various Fields
- Inflammasome and immune disorders
First Affiliated Hospital of Gannan Medical University
2022-2025
Dalian Medical University
2022-2025
First Affiliated Hospital of Dalian Medical University
2022-2025
Southern Medical University
2014-2024
Hubei Academy of Agricultural Sciences
2019-2024
Ministry of Agriculture and Rural Affairs
2016-2024
University of Science and Technology of China
2019-2024
Nanfang Hospital
2019-2024
Beijing Geriatric Hospital
2018-2024
Changzhi Medical College
2024
Abstract Motivation: In mammalian cells, many genes are silenced by genome methylation. DNA methyltransferases and polycomb repressive complexes, which both lack sequence-specific DNA-binding motifs, recruited long non-coding RNA (lncRNA) to specific genomic sites methylate chromatin. Increasing evidence indicates that lncRNAs contain motifs can bind forming RNA:DNA triplexes. The identification of lncRNA binding is essential for deciphering functions correct erroneous methylation; however,...
ABSTRACT Cuproptosis is a form of programmed cell death dependent on mitochondrial respiration and crucial in cancer treatment. The study attempted to screen cuproptosis‐associated genes colorectal (CRC) reveal regulatory pathways. Weighted gene co‐expression network analysis (WGCNA) was applied the modules based expression CRC patients. were screened at intersection cuproptosis data set. RNA sequencing performed assess transcriptome changes, followed by functional enrichment analyses...
Importance Electronic cigarettes (ECs) are often used by smokers as an aid to stopping smoking, but evidence is limited regarding their efficacy compared with nicotine replacement therapy (NRT), and no available on how compares that of varenicline. Objective To evaluate whether ECs superior NRT noninferior varenicline in helping quit. Design, Setting, Participants This was a randomized clinical trial conducted at 7 sites China including participants who were smoking least 10 per day...
Accumulating evidence suggests that the pathogenesis of preeclampsia involves poor placentation caused by insufficient trophoblast invasion and impaired uterine spiral artery remodeling, yet underlying molecular mechanism remains unclear. We carried out transcriptome profiling on placentae from preeclamptic patients normal subjects, identified about four hundred long non-coding RNAs differentially expressed in with early-onset severe preeclampsia. Here, we report our identification lncRNA...
Lilium lancifolium Thunb ( L. ) is an important medicinal and edible plant with outstanding functionality for selenium (Se) biofortification. However, the molecular response of to exogenous Se has not been fully elucidated. In this study, effects different levels on growth quality were explored by transcriptome, metabolome biochemical analyses. The results showed that total organic content in bulbs increased increasing dosage (0–8.0 mmol/L). Moreover, stimulated at low level (2.0 mmol/L) but...
Preeclampsia is believed to be caused by impaired placentation with insufficient trophoblast invasion, leading uterine spiral artery remodeling and angiogenesis. However, the underlying molecular mechanism remains unknown. We recently carried out transcriptome profiling of placental long noncoding RNAs (lncRNAs) identified 383 differentially expressed lncRNAs in early-onset severe preeclampsia. Here, we are reporting our identification lncRNA INHBA-AS1 as a potential causal factor...
Genomic imprinting is regulated by lncRNAs and important for embryogenesis, physiology behaviour in mammals. Aberrant causes diseases disorders. Experimental studies have examined genomic primarily humans mice, thus leaving some fundamental issues poorly addressed. The cost of experimentally examining imprinted genes many tissues diverse species makes computational analysis lncRNAs' DNA binding sites valuable.We performed lncRNA/DNA clusters from multiple mammalian clades discovered the...
Abstract Aims The study aims to evaluate the reporting and methodological quality of systematic reviews meta‐analyses on nursing interventions in field heart failure investigate whether has been improved after PRISMA statement was published. Methods Pubmed, Cochrane Database Systematic Review, Embase databases were searched from inception July 31, 2018. Two authors independently extracted data October 1, 2018, AMSTAR checklists used assessed quality. Results 50 English articles satisfied...
While blended learning has been growing in popularity recent years, the effectiveness of this procedure remains controversial. In report, we assess embryology within international medical students. The participants were students taking Bachelor Medicine and Surgery program. group (BLG) consisted (n = 43) 2018-2019 academic year, taught with model via a customized small private online course (SPOC). control traditional teaching (TTG) 48) 2017-2018 model. Academic performance, including mean...
Lewy bodies and neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) body dementia (LBD). Whereas alpha-synuclein has been found to be major component body, mechanisms by which neurons degenerate, as well basic involved in formation alpha-synuclein-related inclusions, remain obscure. We have suggested previously that potential are likely leave a "molecular signature" or protein adduct within examples such signatures previous studies. In this study, we...
Systematic reviews (SRs) and meta-analyses (MAs) are distillation of current best available evidence, but potentially prone to bias. The bias SRs MAs comes from sampling bias, selection within study So, their reporting quality is especially important as it may directly influence utility for clinicians, nurses, patients policy makers. on nursing interventions in with Alzheimer's disease (AD) have been increasingly published over the past decade, article has not evaluated after introduction...
Background: Osteoporosis is frequently observed in patients with chronic pancreatitis, and both conditions are closely associated systemic metabolic disorders. However, the underlying mechanisms linking pancreatitis osteoporosis remain unclear. Methods: In this study, we utilized high−performance liquid chromatography–mass spectrometry (HPLC−MS) to conduct metabolomics lipidomics analyses on pancreatic, serum, other tissues from a mouse model of pancreatitis−induced (CP−OP), aim elucidate...
Survival analysis methods have gained widespread use in the filed of oncology. For achievement reliable results, methodological process and report quality is crucial. This review provides first examination characteristics reporting survival articles published leading Chinese oncology journals.To examine analysis, to identify some common deficiencies, desirable precautions relate advice for authors, readers, editors.A total 242 were included be evaluated from 1492 4 journals 2013. Articles...
Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which might be involved diseases originated the placenta remains unknown. Here, we have systematically profiled editome on placentae, 9 from patients with early-onset severe preeclampsia (EOSPE) 32 normal subjects, a widespread dysregulation EOSPE has been identified. mis-edited gene set enriched known preeclampsia-associated genes differentially expressed EOSPE....