A5007460791- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Hepatitis C virus research
- Telomeres, Telomerase, and Senescence
- DNA and Biological Computing
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- HIV/AIDS Research and Interventions
- Birth, Development, and Health
- Hepatitis Viruses Studies and Epidemiology
- Chemical Reactions and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Vaccine Coverage and Hesitancy
- Cancer Cells and Metastasis
- Algorithms and Data Compression
- Cancer-related molecular mechanisms research
- Plant responses to water stress
- Neurological diseases and metabolism
- Inflammasome and immune disorders
- Toxoplasma gondii Research Studies
- Toxin Mechanisms and Immunotoxins
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
Zhengzhou University
2025
Qingdao University of Science and Technology
2023-2024
Southern Medical University
2012-2024
Nanfang Hospital
2006-2024
Ruijin Hospital
2024
Hongik University
2022-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Xinyang Normal University
2023-2024
Guangdong Academy of Medical Sciences
2024
Abstract Reducing hepatitis B virus (HBV) mother-to-child transmission (MTCT) is a fundamental step toward the HBV elimination goal. The multicentred, multilevel SHIELD program aimed to use an intense intervention package reduce MTCT in China. This study was conducted diverse health settings across China, encompassing 30,109 pregnant women from 178 hospitals, part of interim analysis stage II program, and 8,642 160 community-level facilities III program. found that overall rate 0.23% (39...
Background: Patients with preeclampsia display a spectrum of onset time and severity clinical presentation, yet the underlying molecular bases for early-onset late-onset subtypes are not known. Although several transcriptome studies have been done on placentae from PE patients, only small number differentially expressed genes identified due to very sample sizes no distinguishing subtypes. Methods: We carried out RNA-seq 65 high-quality placenta samples, including 33 30 patients 32 control...
Oxygen is a critical factor for the survival of most lifeforms, as inadequate availability disrupts internal metabolic balance. Hypoxia-induced disruptions in glucose metabolism can be fatal to many animals. However, there currently limited research on energy species that inhabit environments with intermittently low oxygen levels. In this study, we investigated gluconeogenic response patterns adult Lasiopodomys brandtii (Brandt's vole) and Mus musculus (Kunming mice) under hypoxia (10% O2,...
Background: Disulfiram (DSF), a Food and Drug Administration (FDA)-approved drug for chronic alcohol addiction, has anti-inflammatory effects that help prevent various cancers, Cu 2+ can enhance the of DSF.Inflammatory bowel diseases (IBD) are characterized by or recurrent relapsing gastrointestinal inflammation.Many drugs targeting immune responses IBD have been developed, but their application many problems, including side high costs.Therefore, there is an urgent need new drugs.In this...
Accumulating evidence suggests that the pathogenesis of preeclampsia involves poor placentation caused by insufficient trophoblast invasion and impaired uterine spiral artery remodeling, yet underlying molecular mechanism remains unclear. We carried out transcriptome profiling on placentae from preeclamptic patients normal subjects, identified about four hundred long non-coding RNAs differentially expressed in with early-onset severe preeclampsia. Here, we report our identification lncRNA...
Preeclampsia is believed to be caused by impaired placentation with insufficient trophoblast invasion, leading uterine spiral artery remodeling and angiogenesis. However, the underlying molecular mechanism remains unknown. We recently carried out transcriptome profiling of placental long noncoding RNAs (lncRNAs) identified 383 differentially expressed lncRNAs in early-onset severe preeclampsia. Here, we are reporting our identification lncRNA INHBA-AS1 as a potential causal factor...
Excessive fat deposition leads to obesity and cardiovascular diseases with abnormal metabolism. Pantothenic acid (PA) is a major B vitamin required for energy However, the effect of PA on lipid metabolism has not been explored. We investigated effects molecular mechanism accumulation as well influence adipogenic marker genes in both adult male mice primary adipocytes. First, we demonstrated that attenuates weight gain fed high-fat diet (HFD). Besides, supplementation substantially improved...
Background: Chronic inflammation caused by immune cells is the central link between obesity and insulin resistance. Targeting inflammatory process a highly promising method for reversing systemic Methods: Blood samples were prospectively collected from 68 patients with type 2 diabetes. C57BL/6J mice fed either high-fat diet (HFD) or normal chow (NC). We performed phenotypical functional analyses of using flow cytometry. Vitamin D receptor (VDR) knockout γδ T constructed Cas9-gRNA targeted...
The World Health Organization (WHO) has set the goal of eliminating hepatitis as a threat to public health by 2030. Blocking mother-to-child transmission (MTCT) B virus (HBV) is not only key viral hepatitis, but also hot issue in field prevention and treatment. To standardize clinical management preventing MTCT HBV achieve zero infection among infants, Chinese Foundation for Hepatitis Prevention Control organized experts compile algorithm based on latest research progress guidelines,...
Background and Aims: The World Health Organization (WHO) Western Pacific Region set a target of eliminating mother-to-child transmission (MTCT) hepatitis B virus (HBV) by 2030. To assess the feasibility this in China, we carried out an epidemiological study to investigate status quo MTCT real-world setting.
Abstract Background Postpartum alanine transaminase (ALT) flares occur frequently in chronic hepatitis B virus (HBV)-infected mothers with antepartum antiviral therapy (AVT). We aimed to characterize the T cell immunity HBV-infected experiencing postpartum ALT flares. Methods Twenty pregnant women who received AVT at 26–28 weeks of gestation were enrolled and followed up until 15–18 postpartum. Among 20 women, 6 experienced flare (AF mothers), while 14 did not (NAF mothers). lymphocyte...
DNA data storage systems have rapidly developed with novel error-correcting techniques, random access algorithms, and query systems. However, designing an algorithm for is challenging, mainly due to the unpredictable nature of errors extremely high price experiments. Thus, a simulator interest that can imitate error statistics system replace experiments in developing processes. We introduce generative adversarial networks learn channel statistics. Our takes oligos (DNA sequences write) as...
Finding a biomarker that indicates the subject’s age is one of most important topics in biology. Several recent studies tried to extract from brain imaging data including fMRI data. However, them focused on MRI data, which do not provide dynamics and lack attempts apply recently proposed deep learning models. We propose neural network model estimates subject images using recurrent (RNN), more precisely, gated unit (GRU). applying networks trivial due high dimensional nature In this work, we...
Hepatitis B virus (HBV) infection is more likely to develop a state of chronicity in early life, particularly mother-to-child transmission (MTCT) HBV the fetus during pregnancy. Till now, little known about impact chronic on immune status maternal-fetus interface, and profile placental lymphocytes MTCT poorly understood.Thirteen term pregnant women with (HBV-PW) thirteen normal as healthy control (HC-PW) were enrolled. The cells paired peripheral blood analyzed by flow cytometry...
Objective: To investigate the impact of immediate cessation antiviral therapy on postpartum liver function and factors influencing abnormality in mothers with chronic hepatitis B virus infection. Methods: A retrospective cohort study was conducted. One hundred eighty-eight pregnant women HBV DNA level > 2×106 IU/ml were enrolled from June 2014 to 2018. Demographic information clinical data load during gravidity, intrapartum period collected. According treatment recommendations pregnancy,...
Many DNA storage codes take into account homopolymer and GC-content constraints. Still, these often need to meet additional practical database requirements, such as error correction data queries, necessitating considerable financial time investment in their training or design. As technologies, including sequencing synthesis, continue evolve rapidly, may be retrained redesigned adapt new In this study, we aim design a method for adapting an existing code satisfy constraint, specifically...