A5036778205- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- Bioactive natural compounds
- Amyotrophic Lateral Sclerosis Research
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Phytochemistry and Bioactivity Studies
- Respiratory viral infections research
- Endoplasmic Reticulum Stress and Disease
- Bone Metabolism and Diseases
- Medicinal Plant Pharmacodynamics Research
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Oral Health Pathology and Treatment
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Probiotics and Fermented Foods
- Burkholderia infections and melioidosis
- Gut microbiota and health
- Antifungal resistance and susceptibility
Chengdu Medical College
2014-2024
China National Nuclear Corporation
2024
Guangdong Provincial Center for Disease Control and Prevention
2021-2023
Shanghai Institute of Materia Medica
2018-2022
Academia Sinica
2022
Chinese Academy of Sciences
2018-2022
ShanghaiTech University
2021
University of Chinese Academy of Sciences
2021
Southern Medical University
2019-2020
Guangdong Pharmaceutical University
2017-2020
Cancer stem cells (CSCs) are maintained by inflammatory cytokines and signaling pathways. Tanshinone IIA (Tan-IIA) possesses anti-cancer anti-inflammatory activities. The purpose of this study is to confirm the growth inhibition effect Tan-IIA on human breast CSCs in vitro vivo explore possible mechanism its activity. Human were enriched expanded under serum-free mammosphere culture condition, identified through formation, toluidine blue staining, immunofluorescence flow cytometry analysis...
Hepatitis B virus (HBV) has a crucial role in the progression of hepatocellular carcinoma (HCC). Tumour cells must develop anoikis resistance order to survive before metastasis. This study aimed investigate mechanism IQGAP1 HBV-mediated evasion and metastasis HCC cells. expression was detected by immunohistochemistry, real-time PCR immunoblot analysis. Lentiviral-mediated stable upregulation or knockdown IGAQP1, immunoprecipitation, etc. were used function study. markedly upregulated...
Candida auris can form long-lasting colonies in the hospital environment and on human skin. There is limited evidence regarding efficacy of different methods products for disinfecting hospitals colonized patients to prevent spread C. auris.The minimum inhibitory concentration three disinfectant ("84" disinfectant, IodineTincture quaternary ammonium) 75% ethanol against other species were measured. A pig skin model was used evaluate hand hygiene killing pathogens. The effect ultraviolet-C...
Cancer stem cells (CSCs) are proposed to be responsible for tumor recurrence, metastasis and the high mortality rate of cancer patients. Isolation identification CSCs is crucial basic preclinical studies. However, as there currently no universal markers isolation in any type cancer, method isolating from primary tissues or cell lines costly ineffective. In order establish a reliable model cervical studies, present study was designed enrich using nonadhesive culture system characterize their...
It is well known that dendritic cells (DCs) play a pivotal role in triggering self-specific responses. Conversely, tolerogenic DCs (tolDCs), specialized subset, induce tolerance and negatively regulate autoreactive Tofacitinib, Janus kinase inhibitor developed by Pfizer for treatment of rheumatoid arthritis, probable to be promising candidate inducing tolDCs. The aims this study were evaluate the effectiveness tolDCs induced tofacitinib myelin oligodendrocyte glycoprotein- (MOG-) specific...
Abstract Metabolic reprogramming is a hallmark of cancer. The nicotinamide phosphoribosyltransferase (NAMPT)‐mediated salvage pathway maintains sufficient cellular NAD levels and required for tumorigenesis development. However, the molecular mechanism by which NAMPT contributes to HBV‐associated hepatocellular carcinoma (HCC) remains not fully understood. In present study, our results showed that protein was obviously upregulated in HBV‐positive HCC tissues compared with HBV‐negative...
Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are responsible for the progression and recurrence of GBM after conventional therapy. Morusin possesses anti‐cancer activity in vitro. The purpose this study is to confirm growth inhibition effect morusin on human GSCs vitro vivo explore possible mechanism its activity. Human were enriched under nonadhesive culture system, characterized through neurosphere formation, toluidine blue staining, immunofluorescence Western blotting analysis...
Non-alcoholic fatty liver disease is a public health problem worldwide associated with high morbidity and hepatic steatosis, but no effective therapeutic interventions. Magnesium isoglycyrrhizinate (MGIG), derivative of an active component Glycyrrhiza glabra, widely used for the treatment inflammatory diseases due to its potent anti-inflammatory hepatoprotective activities. Hence, this study aimed effects MGIG on steatosis in mice fed high-fat diet (HFD). Oil Red O staining transmission...
Toll-like receptor 3 (TLR3) is a sensor of endogenous cell necrosis during the process acute inflammation. Interleukin (IL)-1 antagonist (IL-1Ra) an anti-inflammatory cytokine and can negatively regulate pathogenesis However, whether how activation TLR3 IL-1Ra expression has not been clarified. Here, we show that poly(I:C) induces in primarily cultured human fibroblast-like synoviocytes other types cells. Induction by was dependent on TLR3, but independent melanoma...
Benzoxazole and its derivatives have been widely studied in recent years due to their various biological properties. A previous study has demonstrated that K313 (1H-indole-2,3-dione 3-(1,3-benzoxazol-2-ylhydrazone)), a novel benzoxazole derivative, inhibits T cell proliferation yield immunosuppressive effects. However, there are no related reports about anti-inflammatory In the present study, we investigated properties underlying molecular mechanism of lipopolysaccharide (LPS)-induced...
Nicotinamide phosphoribosyltransferase (NAMPT) is a critical rate‑limiting enzyme involved in NAD synthesis that has been shown to contribute the progression of liver cancer. However, potential role and mechanism NAMPT hepatitis B virus (HBV)‑associated cancer remain unclear. The present study assessed expression HBV‑positive ‑negative cells, investigated whether HBV‑induced dependent on HBV X protein (HBx). In addition, replication transcription, HBV‑mediated cell growth was explored....
AbstractLithocarpus polystachyus leaves have been used as tea beverage and folk medicine for healthy care in the Southwest of China. The purpose this study is to investigate anticancer activity Lithocarpus Rehd leaf aqueous extract (LPAE) explore possible mechanism its activity. Growth inhibition effects LPAE breast cancer were tested vitro vivo. was analyzed with cell biological molecular assays. After treatment, proliferation colony formation cells decreased; apoptotic increased; DNA...
Immunosuppressive drugs have shown great promise in treating autoimmune diseases recent years. A series of novel oxazole derivatives were screened for their immunosuppressive activity. PO-322 [1H-indole-2,3-dione 3-(1,3-benzoxazol-2-ylhydrazone)] was identified as the most effective these compounds. Here, we investigated mechanism(s) underlying inhibition T-cell proliferation vitro by PO-322, well its effects on delayed-type hypersensitivity (DTH) response and imiquimod-induced dermatitis...
We aimed to determine the accuracy of self-reported diabetes, hypertension, and hyperlipidemia in Chinese adults examine factors that affect self-reports.This representative cross-sectional survey was conducted Liwan District, Guangzhou City, Southeast China. Self-reported data were collected using a structured questionnaire. Biometrical recorded, including blood lipid, glucose arterial pressure levels. Sensitivity, specificity, κ values self-reports used as measurements or agreements. The...
Aquatic animals are now recognized to be major hosts of potentially pathogenic Laribacter hongkongensis. A comparative study was carried out among extended-spectrum β-lactamase (ESBL)-producing L. hongkongensis isolated from frogs (47 isolates) and fish (41 examine phenotypic genotypic antimicrobial resistance profiles, integrons, virulence factors, genetic relatedness. Isolates showed a higher incidence antibiotic compared with those for most the antimicrobials tested, especially...