A5114685709- Environmental Toxicology and Ecotoxicology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and genetic disorders
- Seaweed-derived Bioactive Compounds
- Zebrafish Biomedical Research Applications
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Sympathectomy and Hyperhidrosis Treatments
- Advanced Glycation End Products research
- Genetic factors in colorectal cancer
- Phytochemistry and Biological Activities
- Phytochemical and Pharmacological Studies
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Medicinal Plant Pharmacodynamics Research
- Fungal Biology and Applications
- Environmental Quality and Pollution
- Environmental Impact and Sustainability
- Nutritional Studies and Diet
- Diet and metabolism studies
- Cancer Mechanisms and Therapy
- Pesticide Exposure and Toxicity
- Food Quality and Safety Studies
- Minimally Invasive Surgical Techniques
Jiangsu Vocational College of Medicine
2023-2025
Yunnan Agricultural University
2022-2024
Minzu University of China
2010-2024
Yichun University
2024
Nanjing Medical University
2017-2023
Peking University People's Hospital
2021
Community Link
2021
Peking University
2021
East China University of Science and Technology
2021
Central South University
2017-2018
Difenoconazole (DIF), a common broad-spectrum triazole fungicide, is associated with an increased risk of cardiovascular diseases. Unfortunately, little attention has been paid to the mechanisms underlying this association. In study, zebrafish embryos were exposed DIF (0, 0.3, 0.6 and 1.2 mg/L) from 4 96 h post fertilization (hpf) toxicity was evaluated. Our results showed that decreased hatching rate, survival rate heart malformation rate. Cardiovascular deformities are most prominent,...
Background The association between dietary indices and metabolic dysfunction-associated steatotic liver disease (MASLD) has shown inconsistent results in previous studies. Additionally, the potential mediating variables linking quality to MASLD have not been adequately explored. Methods We analyzed data from 6,369 participants National Health Nutrition Examination Survey (NHANES) 2007–2018. Three indices—Healthy Eating Index (HEI), Energy-adjusted Dietary Inflammatory (EDII), Composite...
Titanium dioxide nanoparticles (n-TiO2) could enhance the bioavailability and toxicity of coexisting organic contaminants in aquatic environment. This study attempted to investigate combined effects n-TiO2 difenoconazole (DIF) on neurodevelopment zebrafish underlying mechanisms. In this study, embryos were exposed (100 μg/L), DIF (0, 0.1 0.5 mg/L) their mixtures from 4 96 h post fertilization (hpf) neurotoxicity was evaluated. Our results indicated that adsorbed into brain significantly...
Abstract Cortex lycii radicis is the dried root bark of Lycium chinense, a traditional Chinese herb used in multiple ailments. The crude extract has growth inhibition effect on GBM cells. Kukoamine A (KuA) spermine alkaloid derived from it. KuA possesses antioxidant, anti-inflammatory activities, but its anticancer activity unknown. In this study, and migration human cells possible mechanism were investigated. After treatment, proliferation colony formation decreased significantly; apoptotic...
Abstract Background Panax notoginseng (Burk) F. H. Chen is one of the most famous Chinese traditional medicinal plants. The taproot main organ producing triterpenoid saponins, and its development directly linked to quality yield harvested P. . However, mechanisms underlying dynamic metabolic changes occurring during are unknown. Results We carried out metabolomic transcriptomic analyses investigate metabolites gene expression taproots. differentially accumulated included amino acids...
The present study aimed to investigate the occurrence and clinical features of cases multiple primary cancers including colorectal cancer (MPCC). medical records patients with (CRC) who underwent surgery at Third Xiangya Hospital Central South University (Changsha, China) between August 2007 2014 were retrospectively analyzed. Patients MPCCs identified mutation analyses performed on colon specimens. results revealed that among 1,311 CRC, 59 had MPCC (including 35 ≥1 CRC other type, 24 CRCs...
Abstract To investigate the association of familial history (FH) diabetes with glycaemic control status patients type 2 (T2D), a cross-sectional study using stratified cluster sampling was conducted 20,340 diabetic in Jiangsu, China. In total, 21.3% subjects reported FH diabetes. Patients showed higher risk poor (59.7%) than those without (49.8%), an odds ratio (OR) 1.366 ( P < 0.001). Glycaemic did not significantly differ between T2D parental and sibling FH. Compared paternal FH,...
β-actin (ACTB) participates in the vascular remodeling and contributes to cardiovascular diseases. Herein, we investigated associations of ACTB with hypertension stroke.
Background . Smoking is the second leading cause of death. Limited studies are available about smoking and overall diet quality. The current study was aimed at finding an association s-KAP (smoking-related knowledge, attitude, practices) with nutritional status Methodology a cross-sectional community-based conducted in Jurong city, China. Validated questionnaires were used for collection data regarding dietary intake. Correlation multivariate linear regression analysis scores quality status....
Myclobutanil (MYC) is a common triazole fungicide widely applied in agriculture. MYC extensively exists the natural environment and can be detected organisms. However, little known about MYC-induced embryonic developmental damage. This study aimed to unravel cardiotoxicity of underlying mechanisms, as well cardioprotective effect curcumin (CUR, an antioxidant polyphenol) using zebrafish model. Here, embryos were exposed at concentrations 0, 0.5, 1 2 mg/L from 4 96 h post fertilization (hpf)...
In the present study, hereditary non-polyposis colorectal cancer (HNPCC) susceptibility genes were screened for using whole exome sequencing in 3 HNPCC patients from 1 family and single nucleotide polymorphism (SNP) genotyping assays 96 other control samples. Peripheral blood was obtained family; proband proband's brother cousin. High-throughput performed capture technology. Sequences aligned against HAPMAP, dbSNP130 1,000 Genome Project databases. Reported common variations synonymous...
DIAPH1 is a formin protein involved in actin polymerization with important roles vascular remodeling and thrombosis.To investigate potential associations of single-nucleotide polymorphisms (SNPs) hypertension stroke, 2,012 patients 2,210 controls, 2,966 stroke cases [2,212 ischemic (IS), 754 hemorrhagic (HS)] 2,590 controls were enrolled respectively the casecontrol study.A total 4,098 individual included cohort study.DIAPH1 mRNA expression was compared between 66 IS [43 small artery...
Fenvalerate (FEN), a typical type II pyrethroid pesticide, is widely used in agriculture. FEN has been detected the environment and human body. However, neurotoxicity of not well elucidated. This study aimed to explore mechanisms underlying FEN-induced using zebrafish (Danio rerio) model. We also investigated whether curcumin (CUR), polyphenol antioxidant that exhibits neuroprotective properties, can prevent neurotoxicity. Here, embryos were exposed 0, 3.5, 7 14 μg/L from 4 96 h post...