A5001775696- Attention Deficit Hyperactivity Disorder
- Infant Development and Preterm Care
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Reading and Literacy Development
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- Children's Physical and Motor Development
- Zebrafish Biomedical Research Applications
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- RNA modifications and cancer
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Cognitive and developmental aspects of mathematical skills
- Infant Nutrition and Health
- Connective tissue disorders research
- Pregnancy and preeclampsia studies
- Child and Adolescent Psychosocial and Emotional Development
- Child Nutrition and Feeding Issues
- Fibroblast Growth Factor Research
- Behavioral and Psychological Studies
- Early Childhood Education and Development
Nanjing Maternity and Child Health Care Hospital
2015-2025
Nanjing Medical University
2016-2025
Women's Hospital
2024
Google (United States)
2024
Second Affiliated Hospital of Nanjing Medical University
2022
Beijing Friendship Hospital
2014
Chinese PLA General Hospital
2006
Shanghai First People's Hospital
2003
Abstract Obesity results from numerous, interacting genetic, behavioral and physiological factors. Adipogenesis is partially regulated by several adipocyte-selective microRNAs (miRNAs) transcription factors that regulate proliferation differentiation of human adipose-derived mesenchymal stem cells (hMSCs-Ad). In this study, we examined the roles miRNAs in hMSCs-Ad to adipocytes. Results showed levels miR-148a, miR-26b, miR-30, miR-199a increased differentiating hMSCs-Ad. Among these miRNAs,...
Difenoconazole (DIF), a common broad-spectrum triazole fungicide, is associated with an increased risk of cardiovascular diseases. Unfortunately, little attention has been paid to the mechanisms underlying this association. In study, zebrafish embryos were exposed DIF (0, 0.3, 0.6 and 1.2 mg/L) from 4 96 h post fertilization (hpf) toxicity was evaluated. Our results showed that decreased hatching rate, survival rate heart malformation rate. Cardiovascular deformities are most prominent,...
Titanium dioxide nanoparticles (n-TiO2) could enhance the bioavailability and toxicity of coexisting organic contaminants in aquatic environment. This study attempted to investigate combined effects n-TiO2 difenoconazole (DIF) on neurodevelopment zebrafish underlying mechanisms. In this study, embryos were exposed (100 μg/L), DIF (0, 0.1 0.5 mg/L) their mixtures from 4 96 h post fertilization (hpf) neurotoxicity was evaluated. Our results indicated that adsorbed into brain significantly...
Journal Article Cohort Profile: The Jiangsu Birth Get access Jiangbo Du, Du State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, ChinaDepartment Epidemiology Biostatistics, School Public China Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuan Lin, Lin Maternal, Child Adolescent Center Global Yankai Xia, Xia ChinaKey Modern Toxicology Ministry Education, https://orcid.org/0000-0003-0484-4035 Hongxia Ma, Ma...
ABSTRACT Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that affect embryonic development. The purpose of this study was to examine the effects exposure PCBs on early retinal development in zebrafish, Danio rerio . Zebrafish embryos were immediately exposed different concentrations (0, 0.125, 0.25, 0.5, 1.0 and 2.0 mg) per liter medium at 28.5 °C. Embryos assessed 30, 48, 72 96 h post‐fertilization (hpf) for changes survival rate, development, larval morphology...
Polychlorinated biphenyls (PCBs), a group of highly toxic environmental pollutants, have been report to influence the visual system development in children. However, underlying mechanism is unclear. The study was aim investigate effects continuous PCBs exposure on optomotor response (OMR) and retinal photoreceptor cell development-related gene expression zebrafish larvae. fertilized embryos were exposed at concentrations 0.125, 0.25, 0.5, 1 mg/L until 7 days post-fertilization. Control...
Neurodevelopmental disorders (NDDs) are a group of induced by abnormal brain developmental processes. The prefrontal cortex (PFC) plays an essential role in executive function, and its NDDs has been reported. associated with high-risk gene mutations share partially overlapping genetic abnormalities.Neurexins (NRXNs) related to autism spectrum disorder (ASD) attention-deficit hyperactivity (ADHD). NRXN1, susceptibility for NDDs, reported be NDDs. However, little is known about key NDDs.NRXN1...
To study the impact of family socioeconomic status on children's reading fluency and chain mediation effect environment living learning styles in this relationship. A total 473 children from grades 2 to 6 two primary schools Nanjing were selected through stratified random sampling. The was assessed, a questionnaire used collect information status, environment, styles. model established using Process macro SPSS, Bootstrap method employed test significance effects. Family significantly...
Objective To evaluate the development level of children’s physiological hand shape indicators and their relationship with grip/pinch strength. Methods Hand strength in 1255 Chinese children aged 5 to 13 years were prospectively measured. Development curves constructed. Results The (full length, middle finger width, wrist thickness) boys girls increased age showed statistically significant differences at different ages. In most groups, larger than same age. After puberty, more rapidly age,...
Enhanced brown adipose tissue (BAT) mass and activity have been demonstrated to promote the expenditure of excess stored energy reduce prevalence obesity. Cold is known as a potent stimulator BAT activates primarily through β 3 -adrenergic-cAMP signaling. Here, we performed RNA-sequencing identify differential miRNAs in mouse upon cold exposure total 20 were validated. With treatment CL-316,243 (CL) forskolin (Fsk) human differentiated adipocyte cells vitro , miR-23b-5p, miR-133a-3p,...
Introduction Inhibition control, as the core component of executive function, might play a crucial role in understanding attention deficit/hyperactivity disorder (ADHD) and specific learning disorders (SLD). control deficits have been observed children with ADHD or SLD. This study sought to test multi-modal fashion (i.e., behavior plus brain imaging) whether inhibition abilities would be further deteriorated due comorbidity Method A total number 90 (aged 6-12 years) were recruited, including...
Objective To characterize a novel gene, Homo sapiens LYR motif containing 1 ( LYRM1 ), that is highly expressed in omental adipose tissue of obese subjects. Methods and results RT-PCR western blot analysis confirmed both mRNA protein levels were higher subjects than normal weight demonstrated expression widely distributed, with the highest occurring tissue. A fusion green fluorescent as well used to identify subcellular localization nucleus. Based on Oil red O staining profile specific...