A5031745156- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Protein Hydrolysis and Bioactive Peptides
- Infant Nutrition and Health
- Birth, Development, and Health
- Antimicrobial Peptides and Activities
- Breastfeeding Practices and Influences
- MicroRNA in disease regulation
- RNA modifications and cancer
- Body Contouring and Surgery
- RNA Research and Splicing
- Aquaculture disease management and microbiota
- Vitamin D Research Studies
- Folate and B Vitamins Research
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Pancreatic function and diabetes
- interferon and immune responses
- Lipid metabolism and disorders
- Electrospun Nanofibers in Biomedical Applications
- Invertebrate Immune Response Mechanisms
- GDF15 and Related Biomarkers
Nanjing Medical University
2016-2025
University of Michigan
2025
Nanjing Maternity and Child Health Care Hospital
2015-2024
Women's Hospital
2020-2023
South China Agricultural University
2022
Ann Arbor Center for Independent Living
2020
Nanjing Normal University
2010-2018
University of Pittsburgh
2014
University of Pittsburgh Medical Center
2010
Northeast Normal University
2008
Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults. Circulating microRNAs (miRNAs) serum have been proposed as potential diagnostic biomarkers, and they may contribute the progression toward T2D. Here, we investigated possibility of predicting future risk adult T2D obese children by using circulating miRNAs.We performed miRNA high-throughput sequencing screen relevant miRNAs children. The expression patterns targeted were further explored adults with To investigate...
The most common complication during pregnancy, gestational diabetes mellitus (GDM), can cause adverse pregnancy outcomes and result in the mother infant having a higher risk of developing type 2 after pregnancy. However, existing therapies for GDM remain scant, with being lifestyle intervention appropriate insulin treatment. MOTS-c, mitochondrial-derived peptide, target skeletal muscle enhance glucose metabolism. Here, we demonstrate that MOTS-c be an effective treatment GDM. A mouse model...
Severe sepsis is associated with increased total peripheral resistance (TPR) and decreased organ blood flow, in which endothelin-1 (ET-1) plays an important role. Plasma levels of ghrelin, a newly-identified endogenous ligand for growth hormone secretagogue receptor potent vasodilatory peptide, are significantly reduced sepsis. Ghrelin downregulation heralds the hypodynamic response severe Therefore, we hypothesized that administration exogenous ghrelin improves flow by ET-1 under such...
Emerging evidences indicate that placenta plays a critical role in gestational diabetes mellitus (GDM). DNA methylation could be associated with altered placental development and functions. This study is to uncover the genome-wide patterns this disorder. was measured at >385 000 CpG sites using methylated immunoprecipitation (MeDIP) huamn island plus promoter microarray. We totally identified 6 641 differentially regions (DMRs) targeting 3 320 genes, of which 2 729 DMRs 1 399 showed...
CBT-Cys click condensation reaction has a high second-order rate constant and found wide applicability in recent years.
Brown adipose tissue (BAT) oxidizes fatty acids for thermogenesis and could therefore be considered as part of a new strategy in combating obesity associated metabolic diseases. It is well established that aging accompanied by decline brown adipocyte regenerative capacity. How contributes to this loss poorly understood. Here, we identify long noncoding RNA, uc.417, which transcribed from an ultraconserved region rodents. Expression uc.417 increases with age. Ectopic expression impairs...
Obesity is associated with a notable risk for disease, including of cardiovascular disorders, type 2 diabetes mellitus (T2DM) and hypertension. Adipose tissue modulates the metabolism by releasing free fatty acids (FFAs) adipokines, leptin, resistin, tumor necrosis factor-α (TNF-α) interleukin 6 (IL‑6). Altered secretion patterns FFAs adipokines have been demonstrated to result in obesity‑associated insulin resistance (IR) inflammatory responses. MicroRNA-199a-3p (miR)-199a-3p expression...
A novel endogenous peptide CAMP<sub>211-225</sub>up-regulated in preterm milk specifically kills<italic>E. coli</italic>and<italic>Y. enterocolitica</italic>through a membrane-disrupting mechanism.
Breastfeeding is associated with a lower incidence of obesity, diabetes, and cardiovascular disease later in life. While macrosomic infants have higher risk developing obesity other metabolic disorders. Breast milk may contain special nutrients to meet the different growth needs infants. Whether mothers make breast requirement still unknown. Here, we conducted comparison between delivering non-macrosomic colostrum endogenous peptides. More than 400 peptides, originating from at least 34...
It is well-established that the mass and function of human brown adipose tissue (BAT) declines with age. A key factor involved in age-related impairment BAT oxidative stress; however, there a paucity studies to date have explored this relationship. Here, we characterized molecular functional alterations vivo mice different ages, treated adipocytes H2 O2 dissect direct effect stress vitro. We further structural changes an stress-induced mouse model aging. found progressive deterioration was...
Abstract Aims The utilization of targeted metabolomics technology promises to facilitate the identification novel metabolic markers in women with gestational diabetes mellitus (GDM), which may turn a more comprehensive investigation underlying mechanisms GDM. Materials and Methods In this study, we used identify serum metabolites from or without differential were categorized analysed using pathway analyses, correlated maternal glucose level, assessed as predictors GDM by receiver operating...
Proteolytic cleavage of proglucagon by prohormone convertase 2 (PC2) is required for islet α cells to generate glucagon. However, the regulatory mechanisms underlying this process remain largely unclear. Here, we report that SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD), a highly conserved protein quality control system responsible clearing misfolded proteins from ER, plays key role in glucagon production regulating turnover nascent proform PC2 enzyme (proPC2). Using...