A5029765615- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Click Chemistry and Applications
- Molecular Sensors and Ion Detection
- Polydiacetylene-based materials and applications
- bioluminescence and chemiluminescence research
- Chemical Synthesis and Analysis
- Sulfur Compounds in Biology
- Nanocluster Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Peptidase Inhibition and Analysis
- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Supramolecular Chemistry and Complexes
- Advanced Nanomaterials in Catalysis
- Photoreceptor and optogenetics research
- Lipid Membrane Structure and Behavior
- Gold and Silver Nanoparticles Synthesis and Applications
- Extracellular vesicles in disease
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
Shandong Agricultural University
2025
State Key Laboratory of Digital Medical Engineering
2018-2025
Southeast University
2018-2025
University of Science and Technology of China
2014-2023
Zhengzhou University
2020-2022
Hefei National Center for Physical Sciences at Nanoscale
2015-2021
Hefei University
2015-2020
Wuhan Engineering Science & Technology Institute
2017-2018
Suzhou Research Institute
2018
Anhui Medical University
2017
Enzymes, a class of highly efficient and specific catalysts in Nature, dictate myriad reactions that constitute various cascades biological systems. Self-assembly, process prevalent also plays important roles biology, from maintaining the integrity cells to performing cellular functions inducing abnormalities cause disease. To explore enzyme-regulated molecular self-assembly an aqueous medium will help understand control those processes. On other hand, certain small organic molecules...
Oridonin (Ori) is the major active ingredient of traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but target Ori remains unknown. NLRP3 a central component inflammasome been involved in wide variety chronic inflammation-driven human diseases. Here, we show that specific covalent inhibitor for inflammasome. forms bond with cysteine 279 NACHT domain to block interaction between NEK7, thereby inhibiting assembly activation. Importantly, both preventive...
We have designed and synthesized a new hydrogelator Nap−FFGEY (1), which forms supramolecular hydrogel. A kinase/phosphatase switch is used to control the phosphorylation dephosphorylation of regulate formation hydrogels. Adding kinase hydrogel induces gel−sol phase transition in presence adenosine triphosphates (ATP) because tyrosine residue converted into phosphate by give more hydrophilic molecule Nap−FFGEY−P(O)(OH)2 (2); treating resulting solution with phosphatase transforms 2 back 1...
Research Article12 March 2018Open Access Source DataTransparent process Tranilast directly targets NLRP3 to treat inflammasome-driven diseases Yi Huang Institute of Immunology and the CAS Key Laboratory Innate Immunity Chronic Disease, Center for Excellence in Molecular Cell Sciences, Hefei National Physical Sciences at Microscale, University Science Technology China, Hefei, China Innovation Signaling Network, Search more papers by this author Hua Jiang Yun Chen State Cellular Stress...
We report the evaluation of cytotoxicity a new type engineered nanomaterials, FePt@CoS2 yolk−shell nanocrystals, synthesized by mechanism Kirkendall effect when FePt nanoparticles serve as seeds. The evaluated MTT assay, shows much lower IC50 (35.5 ± 4.7 ng Pt/mL for HeLa cell) than that cisplatin (230 Pt/mL). In control experiment, cysteine-modified exhibit at 12.0 0.9 μg Pt/mL. Transmission electron microscopy confirms cellular uptake and magnetic properties analysis (SQUID) proves release...
We report a new type of multifunctional nanomaterials, FePt@Fe2O3 yolk-shell nanoparticles, that exhibit high cytotoxicity originated from the FePt yolks and strong MR contrast enhancement resulting Fe2O3 shells. Encouraged by recently observed FePt@CoS2 we used to replace CoS2 as shells further explore applications nanostructures. The ultralow IC50 value (238 +/- 9 ng Pt/mL) nanoparticles likely originates fact slow oxidation release increases cytotoxicity. Moreover, compared with two...
Abstract Compared with conventional tumor photothermal therapy (PTT), mild‐temperature PTT brings less damage to normal tissues, but also thermoresistance, introduced by the overexpressed heat shock protein (HSP). A high dose of HSP inhibitor during might lead toxic side effects. Glucose oxidase (GOx) consumes glucose, leading adenosine triphosphate supply restriction and consequent inhibition. Therefore, a combinational use an GOx not only enhances minimizes toxicity inhibitor. However,...
Abstract Photothermal therapy (PTT), which utilizes near‐infrared light‐absorbing agents to ablate tumor, has emerged as a highly promising anticancer strategy and received intensive clinical trials in recent years. Mild‐temperature PTT, circumvents the limitations of conventional PTT (e.g., thermoresistance adverse effects), is emerging shows great potential forthcoming applications. However, mild‐temperature without adjuvant not able completely eradicate tumors because its therapeutic...
A supramolecular hydrogel based on d-amino acids, which resists hydrolysis catalyzed by proteinase K and offers long-term biostability, exhibits controlled release in vivo, as proved the pharmacokinetics of encapsulated 125I tracers SPECT imaging hydrogel-encapsulated 131I tracers. As first vivo investigation drug properties hydrogel, isotope encapsulation serves a valid, useful assay for characterizing hydrogels vivo. Our results indicate that promise new biomaterials release.
can be prepared from commercial bee pollens by a hydrothermal process. These carbon dots of 1-2 nm in size show promising applications cellular imaging and catalysis/photocatalysis.
Abstract Multidrug resistance (MDR) remains the biggest challenge in treating cancers. Herein we propose intracellular self‐assembly of nanodrugs as a new strategy for overcoming MDR. By employing biocompatible condensation reaction, rationally designed taxol derivative Ac‐Arg‐Val‐Arg‐Arg‐Cys(S t Bu)‐Lys(taxol)‐2‐cyanobenzothiazole (CBT‐Taxol) which could be subjected to furin‐controlled and nanoparticles (Taxol‐NPs). In vitro vivo studies indicated that, compared with taxol, CBT‐Taxol...
Abstract Development of photothermal materials which are able to harness sunlight and convert it thermal energy seems attractive. Besides carbon-based nanomaterials, conjugated polymers emerging promising but their facile syntheses remain challenging. In this work, by modification a CBT-Cys click condensation reaction rational design the starting materials, we facilely synthesize poly-2-phenyl-benzobisthiazole (PPBBT) its dihexyl derivative with good properties. Under irradiation either...
Intact and stable bone reconstruction is ideal for the treatment of periodontal destruction but remains challenging. In research, biomaterials are used to encapsulate stem cells or bioactive factors regeneration, but, best our knowledge, using a supramolecular hydrogel their sustained release in defect areas promote regeneration has not been reported. Herein, we well-studied hydrogelator, NapFFY, coassemble with SDF-1 BMP-2 prepare hydrogel, SDF-1/BMP-2/NapFFY. vitro vivo results indicated...
Large magnetic nanoparticles or aggregates are advantageous in their resonance properties over ultrasmall superparamagnetic iron oxide (USPIO) (NPs), but the former cleared faster from blood pool. Therefore, "smart" strategy of intracellular aggregation USPIO NPs is required for enhanced T2-weighted MR imaging. Herein, employing an enzyme-instructed condensation reaction, we rationally designed a small molecule Ac-Asp-Glu-Val-Asp-Cys(StBu)-Lys-CBT (1) to covalently modify prepare...
Oral squamous cell carcinoma (OSCC) is the most common oral cancer, having high recurrence and metastasis features. In addition to surgery, photodynamic therapy (PDT) considered as another effective approach for OSCC treatment. The water solubility of currently available PDT photosensitizers (PSs) poor, lowering their singlet oxygen (1O2) yield consequent efficiency. Strategies PS assembly have been reported increase 1O2 yield, but it still possible further enhance this work, we utilized...
Metastasis-induced high mortality of cancers urgently demands new approaches to simultaneously inhibit primary tumor metastasis and distant growth. Herein, by rational design a trident molecule Nap-Phe-Phe-Lys(SA-CPT)-Lys(SA-HCQ)-Tyr(H2PO3)-OH (Nap-CPT-HCQ-Yp) with three functional "spears" (i.e., phosphotyrosine motif for enzymatic self-assembly, camptothecin (CPT) chemotherapy, hydroxychloroquine (HCQ) autophagy inhibition) nanobrush-nanoparticle-nanofiber transition property, we propose...
Peroxynitrite (ONOO–) is one type of important reactive oxygen/nitrogen species (ROS/RNS) and plays a vital role in many physiological activities. Excessive ONOO– associated with diseases including inflammation, arthritis, inflammatory bowel disease, cancer, neurodegenerative diseases. However, chemiluminescent probe capable detecting endogenous at the acidic condition that might be applied for sensitive diagnosis inflammation-related disease has not been reported. Hence, we designed...
A simple supramolecular hydrogel based on D-glucosamine, a naturally occurring aminosaccharide, promises new biomaterials for applications such as wound healing.
This paper reports the rational design and synthesis of a β-lactam conjugate. Treating conjugate with β-lactamase cleaves scissile amide bond, releases hydrogelator, results in enzymatic formation supramolecular hydrogel. The process involves use bacterial enzymethe one causes antibiotic inactivation accounts for resistance to β-lactams many clinical important pathogensto catalyze It offers an opportunity investigate kinetics these types reactions, screen inhibitors enzyme, provides new...
Here we report a new class of molecular hydrogelators based on the conjugates dipeptide and (naphthalen-2-yloxy)acetic acid. They form hydrogels efficiently—the lowest concentration for them to gel water is 0.07 wt%. Two show ability helical nanofibers within hydrogels, chirality apparently dictates handedness nanofibers—D-peptide L-peptide afford left-handed right-handed self-assembled in respectively. Moreover, MTT assay viability cells indicates that these are biocompatible.
Employing cellular environment for the self-assembly of supramolecular nanofibers biological applications has been widely explored. But using one precursor to differentiate extra- and intracellular environments self-assemble into two different remains challenging. With knowledge that extracellualr some cancer cells contains large amounts alkaline phosphatase (ALP) while their is glutathione (GSH)-abundant in mind, we rationally designed a Cys(SEt)-Glu-Tyr(H2PO3)-Phe-Phe-Gly-CBT (1) can...
Gd smart: MRI contrast agents are presented that based on a biocompatible condensation reaction. Upon reduction, gadolinium-containing cell-permeable small-molecule probe condenses into cyclic oligomers subsequently self-assemble nanoparticles (NPs) with enhanced relaxivity (by 110 % at 1.5 T and 35 °C, 104 in live cells 0.5 T).