A5035353556- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Advanced NMR Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Systemic Sclerosis and Related Diseases
- MRI in cancer diagnosis
- Organ Transplantation Techniques and Outcomes
- Blood groups and transfusion
- Characterization and Applications of Magnetic Nanoparticles
- Magnetism in coordination complexes
- Medical Imaging Techniques and Applications
- Microfluidic and Bio-sensing Technologies
- Electron Spin Resonance Studies
- Photoacoustic and Ultrasonic Imaging
- Child Nutrition and Water Access
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Liver physiology and pathology
- Ultrasound Imaging and Elastography
- Blood properties and coagulation
- Advanced biosensing and bioanalysis techniques
- Atomic and Subatomic Physics Research
- Gastroesophageal reflux and treatments
Shiv Nadar Foundation
2023
University of California, San Francisco
2015-2017
University of California System
2015
Stanford University
2011-2014
Duke Medical Center
2010-2013
Duke University Hospital
2013
Duke University
2010
A strategy of using controlled self-assembly caspase-3/7-sensitive Gd-based MR contrast agent is demonstrated for non-invasive monitoring drug-induced tumor cell death in mice.
Gd smart: MRI contrast agents are presented that based on a biocompatible condensation reaction. Upon reduction, gadolinium-containing cell-permeable small-molecule probe condenses into cyclic oligomers subsequently self-assemble nanoparticles (NPs) with enhanced relaxivity (by 110 % at 1.5 T and 35 °C, 104 in live cells 0.5 T).
Islet transplantation (Tx) represents the most promising therapy to restore normoglycemia in type 1 diabetes (T1D) patients date. As significant islet loss has been observed after procedure, there is an urgent need for developing strategies monitoring transplanted grafts. In this report we describe first time application of magnetic particle imaging (MPI) islets liver and under kidney capsule experimental animals.Pancreatic isolated from Papio hamadryas were labeled with superparamagnetic...
Controlled self-assembly of small molecule gadolinium (Gd) complexes into nanoparticles (GdNPs) is emerging as an effective approach to design activatable magnetic resonance imaging (MRI) probes and amplify the r₁ relaxivity. Herein, we employ a reduction-controlled macrocyclization reaction develop redox activated Gd-based MRI probe for sensing reducing environment. Upon disulfide reduction at physiological conditions, acyclic contrast agent 1 containing dual Gd-chelates undergoes...
Purpose To accelerate T 1ρ quantification in cartilage imaging using combined compressed sensing with iterative locally adaptive support detection and JSENSE. Methods reconstruct images from accelerated acquisition at different time of spin‐lock (TSLs), we propose an approach to combine advanced (CS) based reconstruction technique, LAISD (locally detection), parallel Specifically, the process alternates iteratively among local domain principal component analysis, image sequence, sensitivity...
Purpose Quantitative T1ρ imaging is beneficial for early detection osteoarthritis but has seen limited clinical use due to long scan times. In this study, we evaluated the feasibility of accelerated mapping knee cartilage quantification using a combination compressed sensing (CS) and data‐driven parallel (ARC‐Autocalibrating Reconstruction Cartesian sampling). Methods A sequential ARC CS, both during data acquisition reconstruction, was used accelerate maps. Phantom, ex vivo (porcine knee),...
Lower back pain is one of the main contributors to morbidity and chronic disability in United States. Despite significance problem, it still not well understood. There a clear need for objective, non-invasive biomarkers localize specific generators identify early stage changes enable reliable diagnosis treatment. In this study we focus on intervertebral disc degeneration as source lower pain. Quantitative imaging markers T1ρ T2 have been shown be promising techniques vivo biochemical discs...
<h3>SUMMARY:</h3> Our aim was to prospectively evaluate the relationship between low back pain–related disability and quantitative measures from [<sup>18</sup>F]-sodium fluoride ([<sup>18</sup>F]-NaF) MR imaging. Six patients with facetogenic pain underwent dynamic [<sup>18</sup>F]-NaF PET/MR PET metrics were correlated clinical imaging grading of lumbar facet arthropathy. A significant positive correlation observed maximum joint uptake rate (<i>P</i> < .05). These data suggest that may...
The Bloch‐Siegert (B‐S) B 1 + mapping technique is a fast, phase‐based method that highly SAR limited especially at 7T, necessitating the use of long repetition times. Spiral and echo‐planar readouts were incorporated in gradient‐echo based B‐S sequence to reduce specific absoprtion rate (SAR) improve its scan efficiency. A novel, numerically optimized 4 ms off‐resonant pulse 1960 Hz was used increase sensitivity further compared with conventional 6 Fermi pulse. Using spiral readouts, time...
With the development of numerous mouse models cancer, there is a tremendous need for an appropriate imaging technique to study disease evolution. High-field T(2)-weighted using PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) MRI meets this need. The two-shot presented here provides (a) high spatial resolution, (b) contrast and (c) rapid noninvasive imaging, which enables high-throughput, longitudinal studies in free-breathing mice. Unique data...
Abstract A simple technique is implemented for correction of artifacts arising from nonuniform T 2 ‐weighting k ‐space data in fast spin echo–based PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction). An additional blade no phase‐encoding gradients acquired to generate the scaling factor used correction. Results simulations and phantom experiments, as well vivo experiments free‐breathing mice, demonstrate advantages proposed method. This developed...