A5034614702- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Dendrimers and Hyperbranched Polymers
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Metal-Organic Frameworks: Synthesis and Applications
- Immune cells in cancer
- Nanocluster Synthesis and Applications
- Boron Compounds in Chemistry
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Gout, Hyperuricemia, Uric Acid
- Gold and Silver Nanoparticles Synthesis and Applications
- Demographic Trends and Gender Preferences
- Photodynamic Therapy Research Studies
- Radiation Therapy and Dosimetry
- 2D Materials and Applications
- Liver Disease Diagnosis and Treatment
- Carbon and Quantum Dots Applications
- Liver Disease and Transplantation
Jiangnan University
2023-2025
Wuxi Fourth People's Hospital
2024
University of Science and Technology of China
2017-2023
Zhuhai People's Hospital
2019-2021
Jinan University
2019-2021
Jinan University
2021
Hefei University
2015-2019
Hefei University of Technology
2014-2017
Zhejiang Business Technology Institute
2016
State Council of the People's Republic of China
2015
The deep and inner beds of solid tumors lack lymphocytic infiltration are subjected to various immune escape mechanisms. Reversing immunosuppression within the tumor is vital in clinical cancer therapy, however it remains a huge challenge. In this work, we have demonstrated use second window near-infrared (NIR(II)) photothermal treatment trigger more homogeneous deeper immunogenic cell death tumors, thereby eliciting both innate adaptive responses for control metastasis prevention....
Extensive efforts have been devoted to synthesizing photothermal agents (PTAs) that are active in the first near-infrared (NIR) region (650–950 nm). However, PTAs for therapy second NIR window (1000–1350 nm) still rare. Here, it is shown two-dimensional ultrathin polypyrrole (PPy) nanosheets prepared via a novel space-confined synthesis method could exhibit unique broadband absorption with large extinction coefficient of 27.8 L g–1 cm–1 at 1064 nm and can be used as an efficient PTA window....
Abstract Development of photothermal materials which are able to harness sunlight and convert it thermal energy seems attractive. Besides carbon-based nanomaterials, conjugated polymers emerging promising but their facile syntheses remain challenging. In this work, by modification a CBT-Cys click condensation reaction rational design the starting materials, we facilely synthesize poly-2-phenyl-benzobisthiazole (PPBBT) its dihexyl derivative with good properties. Under irradiation either...
Ferroptosis is a form of iron-dependent, lipid peroxidation–driven regulatory cell death that has been implicated in the pathogenesis multiple diseases, including organ injury, ischemia/reperfusion, and neurodegenerative diseases. However, inhibitors directly specifically target ferroptosis are not yet available. Here, we identify compound AS-252424 (AS) as potent inhibitor through kinase library screening. Our results show AS effectively inhibits peroxidation both human mouse cells....
Intratumoral glucose depletion-induced cancer starvation represents an important strategy for anticancer therapy, but it is often limited by systemic toxicity, nonspecificity, and adaptive development of parallel energy supplies. Herein, we introduce a concept cascaded catalytic nanomedicine combining targeted tumor deoxygenation-activated chemotherapy efficient treatment with reduced toxicity. Briefly, nanoclustered enzymes were synthesized covalently cross-linking oxidase (GOx) catalase...
Both diffusion-limited and perfusion-limited hypoxia are associated with tumor progression, metastasis, the resistance to therapeutic modalities. A strategy that can efficiently overcome both types of enhance efficacy cancer treatment has not been reported yet. Here, it is shown by using biomimetic ultrathin graphdiyne oxide (GDYO) nanosheets, be simultaneously addressed toward an ideal photodynamic therapy (PDT). The GDYO which oxidized exfoliated from (GDY), able catalyze water oxidation...
Precisely controlling the interaction of nanoparticles with biological systems (nanobio interactions) from injection site to targets shows great potential for biomedical applications. Inspired by ability alter their physicochemical properties according different stimuli, we explored tumor acidity and near-infrared (NIR) light activated transformable nanoparticle DATAT-NPIR&DOX. This consists a acidity-activated TAT [the lysine residues' amines was modified 2,3-dimethylmaleic anhydride (DA)],...
Drug delivery systems with remotely controlled drug release capability are rather attractive options for cancer therapy. Herein, a reactive oxygen species (ROS)-sensitive polymeric nanocarrier TK-PPE@NPCe6/DOX was explored to realize by light-activated size shrinkage. The encapsulating chlorin e6 (Ce6) and doxorubicin (DOX) self-assembled from an innovative ROS-sensitive polymer TK-PPE the assistance of amphiphilic copolymer poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL). Under 660...
A mitochondria-targeting nanoplatform for near-infrared-light-controlled release of nitric oxide accompanied by photothermal therapy was developed, which consists ruthenium nitrosyl functionalized N-doped graphene quantum dots and a triphenylphosphonium moiety. The demonstrated both in vitro vivo anti-tumor efficacy upon irradiation with 808 nm light.
Clinical success of cancer radiotherapy is usually impeded by a combination two factors, i.e., insufficient DNA damage and rapid repair during after treatment, respectively. Existing strategies for optimizing the radiotherapeutic efficacy often focus on only one facet issue, which may fail to function in long term trials. Herein, we report DNA-dual-targeting approach enhanced using hierarchical multiplexing nanodroplet, can simultaneously promote lesion formation prevent subsequent repair....
Abstract Today, exploring ideal photothermal agents (PTAs) for effective therapy (PTT) of cancer is an important issue. Cancer‐related enzyme‐instructed aggregation gold nanoparticles less than 8 nm in diameter will significantly enhance the PTT efficiency traditional PTA nanoparticle (AuNP). Furin a type trans‐Golgi protein convertase upregulated multiple malignancies. However, furin‐instructed intracellular AuNP cells tumor has not yet been reported. Herein, exploiting advantages furin and...
nMOFs embellished with an AuNP nanozyme have great potential to generate O<sub>2</sub> for overcoming the tumor hypoxic microenvironment photodynamic therapy.
Immunogenic cell death (ICD) of tumor cells serves as a crucial initial signal in the activation anti-tumor immune responses, holding marked promise field immunotherapy. However, low immunogenicity tumors pose challenges achieving complete induction ICD, thereby limiting response rates immunotherapy clinical patients. The emergence cuproptosis new form regulated has presented promising strategy for enhanced immunogenic tumors. To trigger cuproptosis, copper-ionophore elesclomol (ES) had to...
Near infrared (NIR) light‐activated supersensitive drug release via photothermal conversion is of particular interest due to its advantages in spatial and temporal control. However, such rarely reported for polymeric nanoparticles. In this study, nanoparticles observed with flowable core can achieve NIR‐activated under the assistance agent. It demonstrated that only 5 s NIR irradiation (808 nm, 0.3 W cm −2 ) leads 17.8% doxorubicin (DOX) release, while almost completely stopped when laser...
Delivery of small interfering RNA (siRNA) by nanocarriers has shown promising therapeutic potential in cancer therapy. However, poor understanding the correlation between physicochemical properties and their interactions with biological systems significantly hindered its anticancer efficacy. Herein, order to identify optimal size for siRNA delivery, different sized cationic micellar nanoparticles (MNPs) (40, 90, 130, 180 nm) are developed that exhibit similar binding efficacies, shapes,...
Multidrug resistance (MDR) has been recognized as a key factor contributing to the failure of chemotherapy for cancer in clinic, often due insufficient delivery anticancer drugs target cells. For addressing this issue, redox-responsive polyphosphoester-based micellar nanomedicine, which can be triggered release transported tumor cells, developed. The micelles are composed diblock copolymers with hydrophilic PEG block and hydrophobic polyphosphoester (PPE) bearing disulfide bond side group....
Recently, micelles, which are self-assembled by amphiphilic copolymers, have attracted tremendous attention as promising drug delivery systems for cancer treatment. Thus, the hydrophobic core of could efficiently encapsulate small molecular drug, will play a significant role anticancer efficiency. Unfortunately, effect hydrophobicity micellar on its efficiency was rarely reported. Herein, diblock polymers poly(ethylene glycol) and polyphosphoester with different side groups (butyl, hexyl,...
Abstract Solid tumors are characterized by a hypoxic and immunologically “cold” microenvironment that dramatically limits the therapeutic outcomes of immunotherapy. Thus, strategies materials capable reversing immunosuppression in immune‐cold highly desired. Herein, it is reported oxygen (O 2 ) self‐supplementing conjugated microporous polymer nanosheets can be utilized to elicit robust antitumor T cell immune response immunosuppressive tumor microenvironment. The ultrathin generate O...
Multidrug resistance (MDR) is the major cause for chemotherapy failure, which constitutes a formidable challenge in field of cancer therapy. The synergistic chemo-photothermal treatment has been reported to be potential strategy overcome MDR. In this work, rationally designed enzyme-degradable, hyperbranched polyphosphoester nanomedicines were developed reversing MDR via codelivery doxorubicin and IR-780 (hPPEDOX&IR) as combined amphiphilic polyphosphoesters with phosphate bond branching...
Redox-responsive polymers exhibit great potential as drug delivery systems. Herein, a redox-responsive PEGylated hyperbranched polyphosphoester (PPE) was synthesized through (A2 + B3) type polycondensation. The obtained PPE can self-assemble into nanoparticles in water. biocompatibility of the evaluated. hydrophobic chemotherapy doxorubicin (DOX) be efficiently encapsulated nanoparticles. Such DOX-loaded exhibited excellent stability due to PEGylation, and showed release behavior. In...