A5100407945- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- Breast Cancer Treatment Studies
- Analytical Chemistry and Chromatography
- Luminescence Properties of Advanced Materials
- Photopolymerization techniques and applications
- Cerebrovascular and Carotid Artery Diseases
- Spine and Intervertebral Disc Pathology
- Bone Tissue Engineering Materials
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Musculoskeletal pain and rehabilitation
- Advanced Breast Cancer Therapies
- Plant Toxicity and Pharmacological Properties
- Analytical chemistry methods development
- Intracranial Aneurysms: Treatment and Complications
- Electrospun Nanofibers in Biomedical Applications
- Proteoglycans and glycosaminoglycans research
- Medical and Biological Ozone Research
- Cancer survivorship and care
- Adrenal and Paraganglionic Tumors
Tianjin Medical University
2009-2024
Tianjin Children's Hospital
2024
Tianjin University
2024
First Affiliated Hospital of Wannan Medical College
2024
Zhejiang Chinese Medical University
2023-2024
Huazhong Agricultural University
2024
Central China Normal University
2023
Xinyang College of Agriculture and Forestry
2023
Bioprocess Control (Sweden)
2023
Xi'an Polytechnic University
2022
Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It yet be clarified whether inhibition represents the mechanism of action Deferoxamine on recovery. A rat model at thoracic 10 segment was established using modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in group intraperitoneally injected with 100 mg/kg 30 minutes before injury. Simultaneously, Sham and...
Extensive efforts have been devoted to synthesizing photothermal agents (PTAs) that are active in the first near-infrared (NIR) region (650–950 nm). However, PTAs for therapy second NIR window (1000–1350 nm) still rare. Here, it is shown two-dimensional ultrathin polypyrrole (PPy) nanosheets prepared via a novel space-confined synthesis method could exhibit unique broadband absorption with large extinction coefficient of 27.8 L g–1 cm–1 at 1064 nm and can be used as an efficient PTA window....
Abstract Current antigen‐encapsulated multifunctional nanovaccines for oncotherapy suffer from limited antigen loading efficiency, low yield, tedious manufacture, and systemic toxicity. Here, an antigen‐directed strategy the fabrication of nanovaccine with ultrahigh efficiency in a facile way tumor photothermal‐immunotherapy is shown. As proof concept, model ovalbumin (OVA) used as natural carrier to load representative theranostic agent indocyanine green (ICG). Mixing OVA ICG aqueous...
Electrochemically fully functional, edible supercapacitors are presented. All materials involved in generating the explicitly originated from and nontoxic food products, including activated charcoal, seaweed, cheese, polyelectrolyte drink, so on. The demonstrated to kill disease-causing bacteria vitro power a commercial snake camera, which renders huge potential be used novel biomedical devices. As service our authors readers, this journal provides supporting information supplied by authors....
Frontal polymerization was successfully utilized, for the first time, to obtain pH/temperature-sensitive hydrogel-based molecularly imprinted polymers (hydroMIPs).
Gastrin is a gastrointestinal peptide hormone that plays an important role in the progression of colorectal cancer (CRC). However, molecular mechanism remains unclear. In this study, we identified gastrin-related circRNAs via high-throughput sequencing and selected circRNA_0017065 as research focus. We further studied its specific CRC. Knockdown overexpression were performed, biological function CRC was vitro vivo functional experiments. The potential downstream target genes subsequently...
Precise genome editing in complex genomes is enabled by engineered nucleases that can be programmed to cleave a site-specific manner. Here, we fused the small, sequence-tolerant monomeric nuclease domain from homing endonuclease I-TevI transcription-like activator effectors (TALEs) create Tev-TALE (Tev-mTALENs). Using PthXo1 TALE scaffold optimize Tev-mTALEN architecture, found choice of N-terminal fusion point on greatly influenced activity yeast-based assays, and length linker used...
A novel molecularly imprinted polymer co-doped by polyhedral oligomeric silsesquioxane and molecular sieve for gastroretentive drug-controlled release.
Photothermal therapy with minimal invasiveness and high selectivity has been regarded as a powerful technique for tumor to overcome the risks of toxic side effects limited therapeutic efficacy clinic cancer treatments. Among various photothermal agents, polypyrrole (PPy) nanoparticles show promising prospect in ablation vivo due their admirable biocompatibility outstanding performance. Besides, are extensively applied biosensors, electrochemical sensors, tissue engineering, flexible...
For the problem that ceramic ring defects are small and difficult to detect with many types; defect feature information is weak extract, this paper proposes an improved YOLOv5-based target detection method achieve of defects. By adding attention mechanism Backbone part YOLOv5, network model different types can be improved, interference irrelevant background reduced, extract channel features spatial more effectively, which effectively enhance capability model. The experimental results show...
Abstract Purpose Previous studies have shown that DNA methyltransferase 3b (Dnmt3b) is the only Dnmt responsive to fracture repair and Dnmt3b ablation in Prx1-positive stem cells chondrocyte both delayed repair. Our study aims explore influence of Gli1-positive healing mice underlying mechanism. Methods We generated Gli1-CreERT2; Dnmt3bflox/flox (Dnmt3b Gli1ER ) operated tibia fracture. Fracture callus tissues control were collected analyzed by X-ray, micro-CT, biomechanical testing,...
Osteoarthritis (OA) is the most prevalent form of degenerative whole-joint disease. Before final option knee replacement, arthroscopic surgery was widely used joint-preserving surgical treatment. Emerging regenerative therapies, such as those involving platelet-rich plasma, mesenchymal stem cells, and microfragmented adipose tissue (MFAT), have been pushed to forefront treatment prevent progression OA. Currently, MFAT has successfully applied treat different types orthopedic diseases.
Drosophila Ncd proteins are motor that play important roles in spindle organization. and the tubulin dimer highly charged. Thus, it is crucial to investigate Ncd-tubulin interactions presence of ions, especially ions bound or restricted at binding interfaces. To consider ion effects, widely used implicit solvent models treat implicitly continuous environment without focusing on individual ions' effects. But charged biomolecules such as may capture some regions ions. Such their sites; thus,...
Abstract Low back pain (LBP) is a common orthopedic disease over the world. Lumbar intervertebral disc degeneration (IDD) regarded as an important cause of LBP. Shensuitongzhi formula (SSTZF) drug used in clinical treatment for diseases. It has been found that SSTZF can have good IDD. But exact mechanism not clarified. The results showed protects against LSI-induced cartilage endplates and discs. Meanwhile, dramatically reduces expression inflammatory factor well catabolism protein...
近年来, 由婴幼儿食品中存在非法添加剂所引起的食品安全问题已经受到了广泛的关注. 表面增强拉曼散射(SERS)技术可以对食品中被禁止添加的常用染料分子罗丹明B (RhB)进行快速无损超灵敏的检测. 通过在类石墨相氮化碳(g-C3N4)纳米片上组装Ag纳米粒子的方式构筑了g-C3N4/Ag复合材料, 并采用透射电子显微镜(TEM)、紫外可见近红外分光光度计(UV-Vis)、X射线衍射仪(XRD)、荧光光谱仪和共聚焦显微拉曼光谱仪(Raman)对复合材料的形貌和结构进行了表征. g-C3N4纳米片不仅具有高度的离域π共轭体系和良好的吸附染料分子的性能, 而且可以作为Ag纳米粒子的载体, 使Ag纳米粒子均匀稳定地分散在其表面. 通过控制实验条件, 优化了测试过程中的pH及基底与RhB的结合时间, 详细探究pH对基底表面等离子共振的影响和对探针分子SERS强度的影响. 由于基底与探针分子之间的静电相互作用及π-π相互作用, 基底可以对阳离子染料进行大量地富集, 从而实现对其检测. 在最佳的实验条件下, 在1.0×10 –9~1.0×10 –6 mol/L浓度范围内,...