A5036697924- Pharmacological Effects of Natural Compounds
- Electrospun Nanofibers in Biomedical Applications
- Advanced Drug Delivery Systems
- Bone Tissue Engineering Materials
- Medicinal Plant Pharmacodynamics Research
- Hydrogels: synthesis, properties, applications
- Berberine and alkaloids research
- Tryptophan and brain disorders
- Osteoarthritis Treatment and Mechanisms
- Traditional Chinese Medicine Analysis
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Drug Solubulity and Delivery Systems
- Natural product bioactivities and synthesis
- Stress Responses and Cortisol
- Saffron Plant Research Studies
- Inhalation and Respiratory Drug Delivery
- Polymer Surface Interaction Studies
- Silk-based biomaterials and applications
- Gastrointestinal motility and disorders
- Ginseng Biological Effects and Applications
- Nanomaterials for catalytic reactions
- Immune Response and Inflammation
- Nanocomposite Films for Food Packaging
- Advanced Nanomaterials in Catalysis
Changchun University of Science and Technology
2025
Tianjin University of Traditional Chinese Medicine
2015-2024
Tianjin haihe hospital
2022-2024
University of Chinese Academy of Sciences
2024
Institutes of Science and Development
2024
Chinese Academy of Sciences
2018-2024
Nanjing University of Chinese Medicine
2024
Xihua University
2024
Soochow University
2020-2023
Xijing Hospital
2007-2023
Polymerization of glycinamide-conjugated monomer alone in concentrated aqueous solution enables facile formation a mechanically strong and highly stable supramolecular polymer (SP) hydrogel because the cooperatively hydrogen-bonded crosslinking strengthening effect from dual amide motifs. This SP exhibits thermoplastic processability, injectability, self-reparability dynamic destruction reconstruction hydrogen bonds response to temperature change. As service our authors readers, this journal...
Abstract In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, fixation approaches onto tissue through suture or phototriggered reaction inevitably cause new damage. Herein, a paintable hydrogel is constructed based on Fe 3+ ‐triggered simultaneous polymerization covalently linked pyrrole and dopamine in hyperbranched chains where situ formed conductive polypyrrole also uniquely serves to crosslink network. This adhesive can be conveniently...
Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological functional recovery after ischemic stroke. The development of new approaches simultaneously diminish oxidative resist is urgently needed. Inspired by the overproduced reactive oxygen species (ROS) at neuron mitochondria, multifunctional nanoparticles with ROS-responsiveness mitochondrial-targeted (SPNPs) were engineered, achieving specific targeting delivery controllable drug release penumbra. Due...
Background and Purpose The edible blue pigments produced by gardenia fruits have been used as value-added colorants for foods in East Asia 20 years. However, the biological activity of derived from genipin has not reported. Methodology/Principal Findings anti-inflammatory effect was studied lipopolysaccharide (LPS) stimulated RAW 264.7 macrophage vitro. secretions nitric oxide (NO) prostaglandin E2 (PGE2) were inhibited concentration-dependent manner pigments. Real-time reverse-transcription...
In liver tissue engineering, scaffolds with porous structure desgined to supply nutrient and oxygen exchange for three-dimensional (3-D) cells culture, maintain functions. Meanwhile, genipin, as a natural crosslinker, is widely used crosslink biomaterials in lower cytotoxicity better biocompatibility. present study, chitosan/gelatin 3-D crosslinked by glutaraldehyde or 1-(3-dimethylaminopropyl)−3-ethyl-carbodimide hydrochloride (EDC) were prepared characterized Fourier-transform infrared...
In this work, a novel starch-based zwitterionic copolymer, starch-graft-poly(sulfobetaine methacrylate) (ST-g-PSBMA), was synthesized via Atom Transfer Radical Polymerization. Starch, which formed the main chain, can be degraded completely in vivo, and pendent segments of PSBMA endowed copolymer with excellent protein resistance properties. This ST-g-PSBMA could self-assemble into physical hydrogel normal saline, studies formation mechanism indicated that generation driven by electrostatic...
Over the last few decades, nanoparticles have been emerging as useful means to improve therapeutic efficacy of drug delivery and medical diagnoses. However, heterogeneity complexity blood a medium is fundamental problem; large amounts protein can be adsorbed onto surface cause their rapid clearance before reaching target sites, resulting in failure delivery. To overcome this challenge, we present rationally designed starch derivative (SB-ST-OC) with both superhydrophilic moiety zwitterionic...
Multiple studies on the pathomechanisms of depressive disorder and antidepressants have been reported. However, literature involving scientometric analysis is sparse. Here, we use a historical review to highlight recent research depression. We former examine disorders from 1998 2018. The latter used identify most frequent keywords in keyword analysis, as well explore hotspots depression trends. Scientometric uncovered field distribution, knowledge structure, topic evolution, topics emergence...
Nanocarrier drug delivery systems (NDDS) have been paid more attention over conventional system for cancer therapy. However, the efficacy is hampered by fast clearance of activated macrophage from blood circulation system. In this study, glycyrrhizin (GL) was introduced into alginate (ALG) nanogel particles (NGPs) to construct multifunctional vehicle decrease and enhance anticancer with combination therapy GL doxorubicin (DOX). Methods: We firstly synthesized GL-ALG NGPs intermolecular...
Acute lung injury (ALI), a severe health-threatening disease, has risk of causing chronic pulmonary fibrosis. Informative and powerful evidence suggests that inflammation oxidative stress play central role in the pathogenesis ALI. Quercetin is well recognized for its excellent antioxidant anti-inflammatory properties, which showed great potential ALI treatment. However, application quercetin often hindered by low solubility bioavailability. Therefore, to overcome these challenges, an...
Brain-derived neurotrophic factor (BDNF) with neuronic development and function is a promising therapeutic agent for treating depressive disorder, according to the neurotrophin hypothesis. However, delivery of BDNF into brain not easy as these large protein molecules cannot efficiently cross blood-brain barrier (BBB) easily suffer oxidative damage in vivo. Therefore, quercetin-based alginate nanogels (quercetin nanogels) loaded have been developed, which could bypass BBB via nose-to-brain...