A5031090880- Microstructure and mechanical properties
- Aluminum Alloy Microstructure Properties
- Aluminum Alloys Composites Properties
- Nanoplatforms for cancer theranostics
- Medicinal Plant Pharmacodynamics Research
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Tryptophan and brain disorders
- Berberine and alkaloids research
- Magnetic Properties and Applications
- Gastrointestinal motility and disorders
- Metal Forming Simulation Techniques
- Magnetic Properties of Alloys
- Stress Responses and Cortisol
- 3D Printing in Biomedical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Metallurgy and Material Forming
- Hydrogels: synthesis, properties, applications
- Traditional Chinese Medicine Analysis
- Wound Healing and Treatments
- Advancements in Transdermal Drug Delivery
- Immune cells in cancer
- Lipid Membrane Structure and Behavior
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
General Research Institute for Nonferrous Metals (China)
2010-2024
Henan Academy of Sciences
2024
State Key Laboratory of Nonferrous Metals and Processes
2023-2024
Grinm Advanced Materials (China)
2023-2024
Peking Union Medical College Hospital
2019-2021
State Council of the People's Republic of China
2021
Institute of Biomedical Science
2019-2020
Tianjin University of Traditional Chinese Medicine
2009-2020
Academy of Military Medical Sciences
2014-2017
Antibacterial hydrogels are attracting extensive attention in soft tissue repair and regeneration, including bacteria-infected-wound healing. The abuse of antibiotics leads to drug resistance. Recent developments have demonstrated that the delivery inorganic bactericidal agents can drive wound healing process; however, this approach is complicated by external light stimuli, cytotoxicity, nondegradability, sophisticated fabrication. Herein, an inherent antibacterial, bioresorbable hydrogel...
Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological functional recovery after ischemic stroke. The development of new approaches simultaneously diminish oxidative resist is urgently needed. Inspired by the overproduced reactive oxygen species (ROS) at neuron mitochondria, multifunctional nanoparticles with ROS-responsiveness mitochondrial-targeted (SPNPs) were engineered, achieving specific targeting delivery controllable drug release penumbra. Due...
Background and Purpose The edible blue pigments produced by gardenia fruits have been used as value-added colorants for foods in East Asia 20 years. However, the biological activity of derived from genipin has not reported. Methodology/Principal Findings anti-inflammatory effect was studied lipopolysaccharide (LPS) stimulated RAW 264.7 macrophage vitro. secretions nitric oxide (NO) prostaglandin E2 (PGE2) were inhibited concentration-dependent manner pigments. Real-time reverse-transcription...
In liver tissue engineering, scaffolds with porous structure desgined to supply nutrient and oxygen exchange for three-dimensional (3-D) cells culture, maintain functions. Meanwhile, genipin, as a natural crosslinker, is widely used crosslink biomaterials in lower cytotoxicity better biocompatibility. present study, chitosan/gelatin 3-D crosslinked by glutaraldehyde or 1-(3-dimethylaminopropyl)−3-ethyl-carbodimide hydrochloride (EDC) were prepared characterized Fourier-transform infrared...
In this work, a novel starch-based zwitterionic copolymer, starch-graft-poly(sulfobetaine methacrylate) (ST-g-PSBMA), was synthesized via Atom Transfer Radical Polymerization. Starch, which formed the main chain, can be degraded completely in vivo, and pendent segments of PSBMA endowed copolymer with excellent protein resistance properties. This ST-g-PSBMA could self-assemble into physical hydrogel normal saline, studies formation mechanism indicated that generation driven by electrostatic...
Nanocarrier drug delivery systems (NDDS) have been paid more attention over conventional system for cancer therapy. However, the efficacy is hampered by fast clearance of activated macrophage from blood circulation system. In this study, glycyrrhizin (GL) was introduced into alginate (ALG) nanogel particles (NGPs) to construct multifunctional vehicle decrease and enhance anticancer with combination therapy GL doxorubicin (DOX). Methods: We firstly synthesized GL-ALG NGPs intermolecular...
Controllable and visible delivery of therapeutic agents is critical for tumor precise therapy. Tumor targeting deep penetration are still challenging issues controllable delivery. Visible drug with imaging navigation can optimize the treatment window personalized medicine. Herein, a biomimetic platelet intelligent vehicle (IRDNP-PLT) was developed to achieve system, driving loading system. The platelets acted as engines repositories exert target functions. fluorescent photothermal agent...
Brain-derived neurotrophic factor (BDNF) with neuronic development and function is a promising therapeutic agent for treating depressive disorder, according to the neurotrophin hypothesis. However, delivery of BDNF into brain not easy as these large protein molecules cannot efficiently cross blood-brain barrier (BBB) easily suffer oxidative damage in vivo. Therefore, quercetin-based alginate nanogels (quercetin nanogels) loaded have been developed, which could bypass BBB via nose-to-brain...
Context: Paeonia lactiflora Pall. (Ranunculaceae) has been used for more than 1000 years in traditional Chinese medicine the treatment of gynecological problems, cramp, pain, giddiness, and congestion. Paeoniflorin, monoterpene glycosides isolated from P. lactiflora, possesses a variety pharmacological activities. However, activity albiflorin, another main glycoside, not well studied.
ABSTRACT Targeting activated macrophages using anti‐inflammatory phytopharmaceuticals has been proposed as general therapeutic approaches for rheumatic diseases. Besides macrophages, chondrocytes are another promising target of agents. Tetrandrine is a major bisbenzylisoquinoline alkaloid isolated from Stephania tetrandrae S. Moore which used 2,000 years an antirheumatic herbal drug in China. Although, the effect tetrandrine demonstrated, mechanism not clearly clarified. In this study, we...
Abstract The construction of bioartificial livers, such as liver organoids, offers significant promise for disease modeling, drug development, and regenerative medicine. However, existing methods generating organoids have limitations, including lengthy complex processes (taking 6–8 weeks or longer), safety concerns associated with pluripotency, limited functionality pluripotent stem cell‐derived hepatocytes, small, highly variable sizes (typically ≈50–500 µm in diameter). Prolonged culture...
Abstract Injectable hydrogels have been paid more attentions on cell therapy and tissue regeneration resulting from the applications in minimally invasive surgical procedures with ease of handling complete filling defect area. Here, a biodegradable injectable situ hydrogel formed by glycyrrhizin (GL), alginate (Alg), calcium (Ca) was developed for three‐dimensional (3D) culture. Differential scanning calorimetry (DSC), X‐ray diffraction (XRD), electron microscope (SEM) rheology analysis were...
Parkinson's disease (PD) is a severe neurodegenerative with high incidence in the elderly and mainly treated by drugs. The blood–brain barrier (BBB) limits entry of oral neuroactive drugs to brain, reducing drug concentration affecting treatment PD. Nanotechnology-based delivery systems, especially thermosensitive allow access brain via nose-brain pathway, which not limited presence BBB. These systems demonstrate outstanding performance enhancing accumulation active drugs, improving loading...
Resveratrol and curcumin, as natural flavones products, have good therapeutic effect in acute chronic inflammation; on the other hand, tetramethylpyrazine (TMP) has angiogenesis vessel protection well anti-inflammatory function. In this paper, of tetramethylpyrazine, resveratrol curcumin (TRC) combination inflammation was reported vivo.The dose combined three products optimized based paw swelling mouse model with a Uniform Design methodology. The TRC investigated by using collagen-induced...