A5100336430- Viral Infections and Immunology Research
- Genetic Mapping and Diversity in Plants and Animals
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Viral gastroenteritis research and epidemiology
- GABA and Rice Research
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Plant Gene Expression Analysis
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Plant Disease Resistance and Genetics
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- SARS-CoV-2 detection and testing
- Plant Molecular Biology Research
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Pancreatic and Hepatic Oncology Research
- Viral Infections and Vectors
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Mosquito-borne diseases and control
China Pharmaceutical University
2024-2025
Anhui Mental Health Center
2024-2025
Anhui Medical University
2023-2025
Shanghai Institute of Microsystem and Information Technology
2025
University of Chinese Academy of Sciences
2025
Shanghai Advanced Research Institute
2025
Chinese Academy of Sciences
2025
Shenzhen Center for Disease Control and Prevention
2016-2025
Tianjin University
2025
Tianjin Medical University
2025
ABSTRACT Sporadic hand, foot, and mouth disease (HFMD) outbreaks other infectious diseases in recent years have frequently been associated with certain human enterovirus (HEV) serotypes. This study explored the prevalences genetic characteristics of non-HEV71 non-coxsackievirus A16 (CV-A16) enterovirus-associated HFMD infections Shenzhen, China. A total 2,411 clinical stool specimens were collected from hospital-based surveillance for 2008 to 2012. The detection HEV was performed by...
Recent evidence has shown the involvement of inflammation in development diabetic peripheral neuropathy (DPN). MicroRNA-146a (miR-146a) is closely involved inflammatory response. However, role miR-146a reaction DPN not been clarified. This study was designed to explore regulation responses DPN.Rats were randomly divided into three groups (n=6 per group): control group, type 2 diabetes mellitus (T2DM) group and group. T2DM rats intraperitoneally injected with streptozotocin. Sciatic nerve...
BackgroundChlamydia psittaci can infect a wide range of avian species, occasionally causing psittacosis (also known as parrot fever) in humans. Most human cases are associated with close contact pet birds or poultry. In December, 2020, an outbreak severe community-acquired pneumonia unknown aetiology was reported hospital Shandong province, China, and some the patients' contacts had respiratory symptoms. Our aims were to determine causative agent this epidemic whether there been...
We developed a new electrochemiluminescence (ECL) platform for ultrasensitive and selective detection of leukemia cells. In order to construct the platform, nonporous gold with controllable three-dimensional porosity good conductivity was used modify screen-printed carbon electrode. The quantum dots (CQDs) coated ZnO nanosphere ([email protected]) were as ECL label low cytotoxicity biocompatibility. Structure characterization obtained by means transmission electron microscopy scanning...
To better understand the molecular mechanisms behind plant growth and leaf senescence in monocot plants, we identified a mutant exhibiting dwarfism an early-senescence phenotype, termed dwarf leaf1 (del1). Histological analysis showed that abnormal was caused by reduction cell number. Further investigation revealed decline number del1 affected cycle. Physiological analysis, transmission electron microscopy, TUNEL assays triggered accumulation of reactive oxygen species. The DEL1 gene cloned...
A novel coronavirus appeared in Wuhan, China has led to major outbreaks. Recently, rapid classification of virus species, analysis genome and screening for effective drugs are the most important tasks. In present study, through literature review, sequence alignment, ORF identification, motif recognition, secondary tertiary structure prediction, whole SARS-CoV-2 were comprehensively analyzed. To find drugs, parameters binding sites calculated by SeeSAR. addition, potential miRNAs predicted...
One major threat to global food security that requires immediate attention, is the increasing incidence of host shift and expansion in growing number pathogenic fungi emergence new pathogens. The more alarming because, yield quality quantity improvement efforts are encouraging cultivation uniform plants with low genetic diversity increasingly susceptible emerging However, influence genome differentiation on pathogen its contribution adaptability still obscure. Here, we compared sequence 6...
Objective Oculopharyngodistal myopathy (OPDM) is an adult‐onset neuromuscular disease characterized by progressive ptosis, dysarthria, ophthalmoplegia, and distal muscle weakness. Recent studies revealed that GGC repeat expansions in 5′‐UTR of LRP12 , GIPC1 NOTCH2NLC are associated with OPDM. Despite these advances, approximately 30% OPDM patients remain genetically undiagnosed. Herein, we aim to investigate the genetic basis for undiagnosed two unrelated Chinese Han families. Methods...
Dendrobium officinale is an important edible and medicinal plant, with the polysaccharide (DOP) being its primary active constituent, known for diverse biological activities. In this study, DOP was extracted characterized structural properties. The potential of to ameliorate gastric ulcers (GUs) investigated using acetic-acid-induced GU model in rats. results demonstrated that exerted a multifaceted protective effect against GU, mitigating deleterious impact on food intake body weight...
Hand, foot, and mouth disease (HFMD) is caused by human enteroviruses, especially enterovirus 71 (EV71) coxsackievirus A16 (CA16). Patients infected with different enteroviruses show varied clinical symptoms. The aim of this study was to determine whether the etiological spectrum mild severe HFMD changed, association between pathogens features. From 2009 2013, a total 2,299 stool or rectal specimens were collected corresponding patient data. A dynamic view in Shenzhen city China provided....
Basic helix-loop-helix (bHLH) is a superfamily of transcription factors that widely found in plants and animals, the second largest factor family eukaryotes after MYB. They have been shown to be important regulatory components tissue development many different biological processes. However, no systemic analysis bHLH has yet reported Sorghum bicolor.
Members of the basic helix-loop-helix (bHLH) transcription factor family perform indispensable functions in various biological processes, such as plant growth, seed maturation, and abiotic stress responses. However, bHLH foxtail millet (Setaria italica), an important food feed crop, has not been thoroughly studied.In this study, 187 genes (SibHLHs) were identified renamed according to chromosomal distribution SibHLH genes. Based on number conserved domains gene structure, divided into 21...
The discrepancy of the electrostatic interaction negatively charged signal molecules to long and short DNA strands modified electrode surface has been used for first time develop an electrochemiluminescence (ECL) biosensor human papillomavirus 16 (HPV 16) detection. single-stranded capture probe (CP) was on gold electrode, which only a small amount negative charge. between tris(2,2′-bipyridyl) ruthenium(II) chloride hexahydrate-doped SiO2 nanoparticles (Ru@SiO2 NPs) CP is weak, hence Ru@SiO2...
Immune escape of emerging SARS-CoV-2 variants concern (VOCs) and waning immunity over time following the primary series suggest importance necessity booster shot COVID-19 vaccines. With aim to preliminarily evaluate potential heterologous boosting, we conducted two pilot studies safety immunogenicity V-01 or a bivalent V-01D-351 (targeting Delta Beta strain) after 5-7 months inactivated COVID-9 vaccine (ICV). A total 77 participants were enrolled, with 20 in study, 27, 30 age stratified...
The large-scale pandemic and fast evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have triggered an urgent need for efficient sensitive on-site nucleic acid testing method with single-nucleotide polymorphism (SNP) identification capability. Here, we report a multiplexed electrical detection assay based on paperclip-shaped probe (PNprobe) functionalized field-effect transistor (FET) biosensor highly specific discrimination SARS-CoV-2 variants. three-stem...
Faecalibacterium prausnitzii is a beneficial human gut microbe and candidate for next-generation probiotics. With probiotics now being used in clinical treatments, concerns about their safety side effects need to be considered. Therefore, it essential obtain comprehensive understanding of the genetic diversity, functional characteristics, potential risks different F. strains. In this study, we collected information 84 F . strains conduct pan-genome analysis with multiple perspectives. Based...
Abstract Background Japanese encephalitis (JE) caused by virus (JEV) accounts for acute illness and death. However, few studies have been conducted to unveil the potential pathogenesis mechanism of JEV. Dendritic cells (DCs) are most prominent antigen-presenting (APCs) which induce dual humoral cellular responses. Thus, investigation interaction between JEV DCs may be helpful resolving viral escape from immune surveillance JE pathogenesis. Results We examined alterations phenotype function...
Dysfunction of early endothelial progenitor cells (EPCs) is responsible for impaired repair capacity after arterial injury in patients with hypertension. Here, we hypothesized that diminished signaling CXC chemokine receptor 7 (CXCR7) contributes to the reduced EPC functions, and enhanced CXCR7 expression restores capacities EPCs from hypertensive patients. was significantly when compared healthy subjects. Meanwhile, phosphorylation p38 mitogen-activated protein kinase, a downstream CXCR7,...
Resveratrol and curcumin, as natural flavones products, have good therapeutic effect in acute chronic inflammation; on the other hand, tetramethylpyrazine (TMP) has angiogenesis vessel protection well anti-inflammatory function. In this paper, of tetramethylpyrazine, resveratrol curcumin (TRC) combination inflammation was reported vivo.The dose combined three products optimized based paw swelling mouse model with a Uniform Design methodology. The TRC investigated by using collagen-induced...