A5100333153- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Hydrogels: synthesis, properties, applications
- Cancer Immunotherapy and Biomarkers
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- Advanced Drug Delivery Systems
- Polymer Surface Interaction Studies
- Antimicrobial Peptides and Activities
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Antimicrobial agents and applications
- Asymmetric Hydrogenation and Catalysis
- Catalytic Processes in Materials Science
- Carbon dioxide utilization in catalysis
- Osteoarthritis Treatment and Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Advanced ceramic materials synthesis
- interferon and immune responses
- Lanthanide and Transition Metal Complexes
- Advanced Polymer Synthesis and Characterization
Northwestern University
2016-2025
Nankai University
2025
State Key Laboratory of Medicinal Chemical Biology
2025
Dalian University of Technology
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Peking Union Medical College Hospital
2014-2024
Stevens Institute of Technology
2022-2024
Yantai University
2024
Wuhan University of Technology
2024
Huashan Hospital
2016-2024
Abstract Metal–organic layers (MOLs) represent an emerging class of tunable and functionalizable two‐dimensional materials. In this work, the scalable solvothermal synthesis self‐supporting MOLs composed [Hf 6 O 4 (OH) (HCO 2 ) ] secondary building units (SBUs) benzene‐1,3,5‐tribenzoate (BTB) bridging ligands is reported. The MOL structures were directly imaged by TEM AFM, doped with 4′‐(4‐benzoate)‐(2,2′,2′′‐terpyridine)‐5,5′′‐dicarboxylate (TPY) before being coordinated iron centers to...
Abstract Ample attention has focused on cancer drug delivery via prodrug nanoparticles due to their high loading property and comparatively lower side effects. In this study, we designed a PEG-DOX-Cur nanoparticle for simultaneous of doxorubicin (DOX) curcumin (Cur) as combination therapy treat cancer. DOX was conjugated PEG by Schiff’s base reaction. The obtained conjugate could self-assemble in water at pH 7.4 into (PEG-DOX NPs) encapsulate Cur the core through hydrophobic interaction...
A novel multifunctional polymeric micelle bearing a pH-tunable on-off module for programmed drug release, folate tumor targeting, and quantum dots fluorescent imaging is described. The can turn release off at neutral pH whereas on inside lysosomes. QD functionalization allows clear elucidation of facile visualization in vivo delivery event. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
The treatment of difficult-to-heal wounds remains a substantial clinical challenge due to deteriorative tissue microenvironment including the loss extracellular matrix (ECM), excessive inflammation, impaired angiogenesis, and bacterial infection. Inspired by chemical components, fibrous structure, biological function natural ECM, antibacterial environment-responsive glycopeptide hybrid hydrogel was developed for chronic wound healing. can facilitate cell proliferation macrophage polarization...
Antibacterial hydrogels are attracting extensive attention in soft tissue repair and regeneration, including bacteria-infected-wound healing. The abuse of antibiotics leads to drug resistance. Recent developments have demonstrated that the delivery inorganic bactericidal agents can drive wound healing process; however, this approach is complicated by external light stimuli, cytotoxicity, nondegradability, sophisticated fabrication. Herein, an inherent antibacterial, bioresorbable hydrogel...
Abstract Wound management remains a major concern in clinical care. Conventional dressings and hydrogels delivering drugs or cells can drive wound healing. However, these approaches are limited either by unnecessary bleeding tissue tearing, sophisticated fabrication, high cost, drug‐related side effects. Herein, novel bioinspired glycopeptide hydrogel is rationally designed to mimic the glycoprotein components nanofibrous architecture of cutaneous extracellular matrix (ECM) for...
Dendritic cells (DCs) are increasingly used in cancer vaccines due to their ability regulate T-cell immunity. Major limitations associated with the present DC adoptive transfer immunotherapy low cell viability and transient duration of transplanted DCs at vaccination site lack recruitment host DCs, leading unsatisfactory immune response. Here, we developed a novel vaccine nodule comprising simple physical mixture peptide nanofibrous hydrogel, anti-PD-1 antibodies, tumor antigens. Upon...
Magnetic/antibacterial bifunctional nanoparticles were fabricated through the immobilization of antibacterial N-halamine on silica-coated Fe(3)O(4)-decorated poly(styrene-co-acrylate acid) (PSA) nanoparticles. The samples characterized by scanning electron microscopy (SEM), transmission (TEM), X-ray photoelectron spectra (XPS), diffraction (XRD), energy-dispersive spectrometry (EDX), Fourier transform infrared (FTIR), and thermogravimetric analysis (TGA). was developed from precursor...
An ideal radiosensitizer holding an enhanced tumor retention can play incredible role in enhancing radiotherapy. Herein, a strategy of acid-triggered aggregation small-sized gold nanoparticles (GNPs) system within is proposed and the resulting GNPs aggregates are applied as vitro vivo. The with achieves accumulation cancer cells tumors form resulted aggregates. As consequence, radiosensitization effect shows significant improvement radiotherapy, which shown studies DNA breakage comet assay,...