A5101461615- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Antimicrobial Peptides and Activities
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer-related gene regulation
- RNA modifications and cancer
- TGF-β signaling in diseases
- Endoplasmic Reticulum Stress and Disease
- Virus-based gene therapy research
- Effects of Radiation Exposure
- Hydrogels: synthesis, properties, applications
- Antibiotic Resistance in Bacteria
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Peptidase Inhibition and Analysis
- Graphene and Nanomaterials Applications
- vaccines and immunoinformatics approaches
- Lanthanide and Transition Metal Complexes
- Electrospun Nanofibers in Biomedical Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
The Ohio State University
2001-2025
Southern Medical University
2024-2025
Nanfang Hospital
2024
Peking Union Medical College Hospital
2016-2023
Tongji Hospital
2020-2023
Huazhong University of Science and Technology
2020-2023
University of Shanghai for Science and Technology
2022-2023
Ministry of Transport
2022
China Medical University
2019-2021
Abstract Wound management remains a major concern in clinical care. Conventional dressings and hydrogels delivering drugs or cells can drive wound healing. However, these approaches are limited either by unnecessary bleeding tissue tearing, sophisticated fabrication, high cost, drug‐related side effects. Herein, novel bioinspired glycopeptide hydrogel is rationally designed to mimic the glycoprotein components nanofibrous architecture of cutaneous extracellular matrix (ECM) for...
Dendritic cells (DCs) are increasingly used in cancer vaccines due to their ability regulate T-cell immunity. Major limitations associated with the present DC adoptive transfer immunotherapy low cell viability and transient duration of transplanted DCs at vaccination site lack recruitment host DCs, leading unsatisfactory immune response. Here, we developed a novel vaccine nodule comprising simple physical mixture peptide nanofibrous hydrogel, anti-PD-1 antibodies, tumor antigens. Upon...
Immunotherapy, an attractive option for cancer treatment, necessitates the direct stimulation of immune cells in vivo and simultaneous effective inhibition immunosuppressive tumor microenvironments. Methods:In present study, we developed injectable PEG-b-poly(L-alanine) hydrogel co-delivery a vaccine dual checkpoint inhibitors to increase immunotherapy efficacy.Tumor cell lysates, granulocyte-macrophage colony stimulating factor (GM-CSF), (anti-CTLA-4/PD-1 antibody) were readily encapsulated...
To prepare folic acid-chitosan conjugated nanoparticles (FA-CS NPs) and evaluate their targeting specificity on tumor cells.Chitosan (CS) NPs were prepared by ionic cross linking method, acid (FA) was with CS electrostatic interaction. The properties of investigated, doxorubicin hydrochloride (Dox) as a model drug encapsulated for investigating release pattern in vitro. cytotoxicity cellular uptake FA-CS also investigated.The results reveal that the obtained monodisperse suitable average...
In the frame of radiotherapy treatment cancer, radioresistance remains a major issue that still needs solutions to be overcome. To effectively improve radiosensitivity tumors and reduce damage radiation neighboring normal tissues, radiosensitizers have been given increasing attention in recent years. As nanoparticles based on metal element gadolinium, AGuIX shown increase cancers. Although it is rare nanomaterial has entered preclinical trials, unclear biological mechanism hinders its...
Excessive reactive oxygen species (ROS) at severe burn injury sites may promote metabolic reprogramming of macrophages to induce a deteriorative and uncontrolled inflammation cycle, leading delayed wound healing regeneration. Here, novel bioactive, anti-fouling, flexible polyzwitterionic hydrogel encapsulated with epigallocatechin gallate (EGCG)-copper (Cu) capsules (termed as [email protected]gel) is engineered for management, which dedicated synergistically exerting ROS-scavenging, immune...
Glucose regulated protein 78 (Grp78) is involved in the invasion and metastasis many human cancers including gastric cancer, breast prostate cancer. But role of Grp78 hepatocellular carcinoma has not been reported. In this article, we examined if was associated with explored possible underlying mechanism. The FAK expression levels 44 patients were using immunohistochemistry. overexpressing SMMC7721 cells established by pcDNA3.1 (+)-Grp78 transfection screened G418. down-regulated siRNA...
In this study, the photochemical internalization (PCI) technique was adopted in a nanoparticle-based antigen delivery system to enhance antigen-specific CD8+ T cell immune response for cancer immunotherapy. Pheophorbide A, hydrophobic photosensitizer, grafted with polyethylenimine (PheoA-PEI) endosome escape activity and near-infrared imaging capability prepared. A model ovalbumin (OVA) then complexed PheoA-PEI form PheoA-PEI/OVA nanoparticles (PheoA-PEI/OVA NPs) that are responsive light....
Nitric oxide (NO) prodrug-conjugated, acid-responsive and galactose receptor targeted nanoparticles were developed for the co-delivery of NO doxorubicin.
The objective of this study was to investigate the spatiotemporal delivery nanomedicines by an injectable, thermosensitive, and nanoparticle-self-aggregated hydrogel for peritumoral chemotherapy. Doxorubicin (Dox) taken as model medicine, which encapsulated into poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT) nanoparticles (PECT/Dox NPs). Macroscale formed thermosensitive self-aggregation...