A5103104552- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Light effects on plants
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Wnt/β-catenin signaling in development and cancer
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Genomics and Phylogenetic Studies
- Ferroptosis and cancer prognosis
- Graphene and Nanomaterials Applications
- Peptidase Inhibition and Analysis
- Amphibian and Reptile Biology
- Liver physiology and pathology
- Genetic diversity and population structure
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Seedling growth and survival studies
Guangzhou University of Chinese Medicine
2025
Jinzhou Medical University
2010-2024
Institute of Crop Sciences
2023
Chinese Academy of Agricultural Sciences
2023
Sichuan University
2021
West China Hospital of Sichuan University
2021
Shaanxi Normal University
2020
Chimie Biologique pour le Vivant
2020
China Medical University
2018-2019
Jinan University
2019
Sorafenib is an effective clinical drug in therapy of hepatocellular carcinoma, having led to improved prognosis carcinoma patients. However acquired resistance still being encountered. So, it urgently develop alternative strategies overcome resistance. Exosomes can be modified with a variety molecules, thereby acting as vehicle for the delivery therapeutic agents. The GRP78 overexpressed resistant cancer cells compared sensitive and thus able act target carcinoma. In this study, we BM-MSCs...
Bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) are progenitor shown to migrate the tumour and participate in microenvironment. BM-MSCs play important roles processes through release of cytokines or exosomes; however, how influence stemness CSCs colon cancer remains poorly understood.We isolated exosomes from used these treat (HCT-116, HT-29 SW-480). We compared traits by cell surface marker (CD133 Lgr5) functional assays, such as chemoresistance, colony formation, adhesion,...
Glucose regulated protein 78 (Grp78) is involved in the invasion and metastasis many human cancers including gastric cancer, breast prostate cancer. But role of Grp78 hepatocellular carcinoma has not been reported. In this article, we examined if was associated with explored possible underlying mechanism. The FAK expression levels 44 patients were using immunohistochemistry. overexpressing SMMC7721 cells established by pcDNA3.1 (+)-Grp78 transfection screened G418. down-regulated siRNA...
Active targeting endocytosis mediated by the specific interaction between folic acid and its receptor has been a hotspot in biological therapy of many human cancers. Various studies have demonstrated that folate conjugates could facilitate chemotherapeutic drug delivery into (FR)-positive tumor cells vitro vivo. In order to utilize FA-FR binding specificity achieve targeted drugs cells, we prepared Gefitinib loaded decorated bovine serum albumin conjugated carboxymethyl-?-cyclodextrin...
Lung cancer is the leading cause of cancer-related deaths worldwide. Tumor suppressor genes remain to be systemically identified for lung cancer. Through genome-wide screening tumor-suppressive transcription factors, we demonstrate here that GATA4 functions as an essential tumor in vitro and vivo. Ectopic expression results cell senescence. Mechanistically, upregulates multiple miRNAs targeting TGFB2 mRNA causes ensuing WNT7B downregulation eventually triggers Decreased level clinical...
Abstract Background As recovery time of diabetic wound injury is prolonged by the production detrimental factors, including reactive oxygen species (ROS) and inflammatory cytokines, attenuating oxidative stress reactions in microenvironment site would be significant. Experimental design In our study, we prepared thermoreversible, antibacterial zeolite-based nanoparticles loaded hydrogel to promote healing via neutralization factors such as cytokines ROS. Results The cerium (Ce)-doped biotype...
Exosomes derived from human bone marrow mesenchymal stem cells (MSC-Exo) are characterized by easy expansion and storage, low risk of tumor formation, immunogenicity, anti-inflammatory effects. The therapeutic effects MSC-Exo on ischemic stroke have been widely explored. However, the underlying mechanism remains unclear. In this study, we established a mouse model brain injury induced occlusion middle cerebral artery using thread bolt method injected into tail vein. We found that...
Abstract Background Snakes as a major reptile group display variety of morphological characteristics pertaining to their diverse behaviours. Despite abundant analyses characters, molecular studies using mitochondrial and nuclear genes are limited. As result, the phylogeny snakes remains controversial. Previous on genomes have demonstrated duplication control region translocation trnL be two notable features alethinophidian (all serpents except blindsnakes threadsnakes) mtDNAs. Our purpose is...
Abstract Background We have reported previously that overexpression of glucose-regulated protein 78 (GRP78) promotes the invasion hepatocellular carcinoma. However, whether GRP78 knockdown affects extracellular matrix degradation has not been elucidated. Here we are going to determine affect ECM and role MMP-2 MMP-9 in these process carcinoma cells. Methods Human cell line SMMC7721 HepG2 were cultured DMEM supplemented with 10% FBS, RT-PCR western blot used detect endogenous expression...
Invasion is a major characteristic of hepatocellular carcinoma and one the main causes refractory to treatment. We have previously reported that GRP78 promotes invasion although mechanism underlying this change remains uncertain. In paper, we explored role cell surface in regulation cancer cells. found neutralization endogenous with anti-GRP78 antibody inhibited adhesion lines Mahlavu SMMC7721. However, forced expression facilitated further demonstrated inhibition specifically secretion...
Emerging data have suggested that cell surface GRP78 is a multifunctional receptor and has been linked to proliferative antiapoptotic signaling cascades. Activated α2-macroglobin (α2M*) natural circulating ligand of GRP78. Association with α2M* involved in the regulation proliferation, survival apoptosis human cancers.The invasion metastasis HCC cells were examined using transwell wound healing assay; Cell expression was detected by western assay. Translocation from cytosol observed...
This study aims to explore the effects of microRNA-214-5p (miR-214-5p) on invasion and migration Hepatocellular Carcinoma cells (HCC).Hepatocellular tissues adjacent normal from 44 hepatocellular carcinoma patients were prepared for this study. The HepG2 BEL-7402 transfected with miR-214-5p mimic inhibitor. qRT-PCR was performed detect expressions miR-214-5p. Transwell assays used in cells. A dual-luciferase reporter assay conducted examine effect Wiskott-Aldrich Syndrome Like (WASL/...
To investigate nurses' core emergency competencies for handling the coronavirus disease-19 (COVID-19) and analyse factors associated with those competencies.COVID-19 has become a major global public health event. Nursing staff have played an important role in COVID-19 prevention control. Understanding their COVID-19, potential disadvantages will help governments to develop targeted training policies improve capacities relation pandemics preparedness.COVID-19 is disastrous infectious disease,...
Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via surface-related GRP78 Liang Zhao,1,* Hongdan Li,2,* Yijie Shi,1 Guan Wang,2 Liwei Liu,1 Chang Su,3 Rongjian Su2 1School of Pharmacy, Liaoning Medical University, Jinzhou, People's Republic China; 2Central Laboratory 3School Veterinary Medicine, China *These authors contributed equally to this work Abstract: (NPs) which target specific agents could effectively recognize the cells increase...
Glioma is recognized as the most common and aggressive primary brain tumor in adults. Owing to occurrence of drug resistance failure penetrate blood-brain barrier (BBB), there no effective strategy for treatment glioma. The main objective this study was develop a biomimetic glioma C6 cell membrane (C6M) derived nanovesicles (DOX-FN/C6M-NVs) loaded with doxorubicin (DOX) ultra-small Fe nanoparticles (FN) accomplishing tumor-targeted delivery DOX improving anti-cancer efficacy via inducing...
Hepatocellular carcinoma (HCC) is one cancer with high death rates. Nowadays, there are no effective drugs to treat it. Cyclovirobuxine D (CVB-D) the primary ingredient of traditional Chinese medicine (TCM) Buxus microphylla. Here, we try explore impacts CVB-D on human HCC cells and explain potential mechanisms.
Maize growth and development are regulated by light quality, intensity photoperiod. Cryptochromes blue/ultraviolet-A receptors involved in stem elongation, shade avoidance, photoperiodic flowering. To investigate the function of cryptochrome 1 (CRY1) maize, where it is encoded ZmCRY1, we obtained two ZmCRY1a genes (ZmCRY1a1 ZmCRY1a2), both which share highest similarity with other gramineous plants, particular rice CRY1a phylogenetic analysis. In Arabidopsis, overexpression promoted seedling...
// Yan-jiao Gu 1,* , Hong-dan Li 2,* Liang Zhao 2 Song 3 Wu-bin He 1 Rui Chang Su 4 Hua-chuan Zheng 5 and Rong-jian Pathology Department, The First Affiliated Hospital of Liaoning Medical College, Jinzhou, China Central Laboratory, Pharmacy Veterinary Medicine Cancer Research Center, Key Laboratory Brain Spinal Cord Injury Province Animal * These authors have contributed equally to this work Correspondence to: Su, email: Keywords : GRP78, chemoresistance, 5-FU, LSF, TS Received April 16,...