A5100396146- Wound Healing and Treatments
- Extracellular vesicles in disease
- Diabetic Foot Ulcer Assessment and Management
- Mesenchymal stem cell research
- Dermatologic Treatments and Research
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Pressure Ulcer Prevention and Management
- Immune cells in cancer
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Laser Applications in Dentistry and Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Nerve injury and regeneration
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Anomalies
- Cellular Mechanics and Interactions
- Hair Growth and Disorders
- Oral microbiology and periodontitis research
- Surgical Sutures and Adhesives
- RNA Interference and Gene Delivery
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
Sun Yat-sen University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Gansu Provincial Hospital
2025
Air Force Medical University
2024
Xijing Hospital
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Nanjing Drum Tower Hospital
2024
Nanjing University
2024
Army Medical University
2023
Southwest Hospital
2023
Abstract Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis remains incompletely understood. Here, we profile 174,962 single cells from the foot, forearm, and peripheral blood mononuclear using single-cell RNA sequencing. Our analysis shows enrichment unique population fibroblasts overexpressing MMP1, MMP3, MMP11, HIF1A, CHI3L1 , TNFAIP6 increased M1 macrophage polarization in DFU patients with healing wounds. Further, spatially separated samples same...
Inflammation occurs throughout the progression of cerebral ischemia/reperfusion and mediates myriads pathological events following an ischemic insult.
Abstract Introduction Wnt and Notch signaling pathways are critically involved in relative cell fate decisions within the development of cutaneous tissues. Moreover, several studies identified above two as having a significant role during wound healing. However, their biological effects tissues repair unclear. Methods We employed self-controlled model (Sprague–Dawley rats with full-thickness skin wounds) to observe action effect Wnt/β-catenin signalings vivo. The quality relevant...
Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential restore the structural integrity and functionality of skin. However, mechanical properties hydrogel scaffolds natural are substantially different. Here, we developed a polyvinyl alcohol (PVA)/acrylamide based interpenetrating network (IPN) that was surface modified with polydopamine (PDA) termed Dopa-gel. The Dopa-gel exhibited similar native tissue superior ability modulate paracrine functions....
Exosomes derived from human bone marrow mesenchymal stem cells (MSC-Exo) are characterized by easy expansion and storage, low risk of tumor formation, immunogenicity, anti-inflammatory effects. The therapeutic effects MSC-Exo on ischemic stroke have been widely explored. However, the underlying mechanism remains unclear. In this study, we established a mouse model brain injury induced occlusion middle cerebral artery using thread bolt method injected into tail vein. We found that...
Basic fibroblast growth factor (bFGF) plays an important role in promoting wound healing and reducing scar, but the possible molecular mechanisms are still unclear. Our previous studies have found that activating Notch1/Jagged1 pathway can inhibit differentiation of epidermal stem cells (ESCs) to myofibroblasts (MFB). Herein, we document bFGF reduces scar by inhibiting ESCs MFB via pathway. In in-vitro study, were isolated from 10 neonatal SD rats (1–3 days old), cultured keratinocyte...
Wound healing is a complex process. Wound-repair materials require multiple functionalities, such as anti-inflammatory, antibacterial, angiogenesis, pro-proliferation, and remodeling. To achieve rapid tissue regeneration, magnetic field-assisted therapy has become promising means. In this study, homogeneous responsive nanocomposite hydrogel with enhanced mechanical properties was obtained through tannin (TA)-assisted bridge between magneto-deformable cobalt ferrite nanoparticles (CFO NPs)...
Abstract Background Autologous epidermal basal cell suspension therapy has been proven to be one of the most effective treatments for full-thickness wounds. However, we found there remain obvious defects that significantly confined utilization and function cells (EBCs), especially stem (ESCs) in it. This study investigated whether precoating fibronectin (FN) on wound bed before spraying EBCs could overcome these further explored its possible mechanisms. Methods In vitro study, were isolated...
Atherosclerotic cardiovascular disease (ASCVD) is a significant public health issue; however, current risk prediction models have limitations in populations with obesity. The aim of this study was to develop for predicting ASCVD patients Gender-specific equations predict were developed and validated using cohort 3,058 participants obesity (body mass index ≥30 kg/m2) the ARIC (Atherosclerosis Risk In Communities) 1,953 MESA (Multi-Ethnic Study Atherosclerosis). new called "ASCVD estimation...
Diabetic foot ulcer (DFU) is one of the most common and complex complications diabetes, but underlying pathophysiology remains unclear. Single-cell RNA sequencing (scRNA-seq) has been conducted to explore novel cell types or molecular profiles DFU from various perspectives. This study aimed comprehensively analyze potential mechanisms impaired re-epithelization in a single-cell perspective. We scRNA-seq on tissues human normal skin, acute wound, investigate epidermal differentiation...
The chronic autoimmune disease rheumatoid arthritis (RA) affects primarily the synovial joints, leading to hip joint deformity and dysfunction manifestations such as acetabular protrusion infection. We present case of a female patient RA complicated by severe syndrome. progressed rapidly with elevated preoperative inflammatory markers, initially overlooking underwent total arthroplasty, intraoperative fluid bacterial culture revealed Gram-negative rod bacteria. Aggressive postoperative...