A nanocomposite of poly(lactide-co-glycolide) (PLGA) and hydroxyapatite (HA) with a different grafting ratio l-lactic acid oligomer (op-HA) showed better interface compatibility, mineralization, osteogenetic abilities. However, surface modification the composite is crucial to improve osteointegration for bone regeneration. In this study, biomimetic process via poly(dopamine) coating was utilized prepare functional substrate surfaces immobilized bioactive peptides that efficiently regulate...

The development of an excellent, bioabsorbable hemostatic material for deep wound remains a challenge. In this work, biodegradable cotton-like biomimetic fibrous mat poly (l-lactic acid) (PLLA) was made by melt spinning. Subsequently, SD composite prepared cross-linking sodium alginate (SA) with dopamine (DA). It immobilized on the fibre surface, which inspired mussel byssus. Finally, Fe

Abstract Composite of nano-hydroxyapatite (n-HAP) surface grafted with poly(L-lactide) (PLLA) (g-HAP) showed improved interface compatibility and mechanical property for bone fracture fixation. In this paper, in vivo degradation n-HAP/PLLA g-HAP/PLLA composite implants was investigated. The properties, molecular weight, thermal properties as well crystallinity the were measured. bending strength n- composites a marked reduction from an initial value 102 114 MPa to 33 24 at 36 weeks,...

Functional biomaterials with magnetic properties are considerably useful for regulating cell behavior and promoting bone regeneration. And the combination of such physical environmental cues (such as fields mechanical stress) might be more favorable regulation function. This study is aimed at investigating combined effects magnetically responsive materials a static field (SMF) on osteogenic differentiation osteoblasts potential mechanism involved. In this study, oleic acid modified iron...

In this study, insulin-like growth factor 1 (IGF-1) was successfully immobilized on the poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) and pure PLGA microcarriers via polydopamine (pDA). The results demonstrated that pDA layer facilitated simple highly efficient immobilization of peptides within 20 min. Mouse adipose-derived stem cells (ADSCs) attachment proliferation IGF-1-immobilized were much higher than non-immobilized ones. More importantly, PLGA/HA significantly increased alkaline...

Fabricating a desired porous structure on the surface of biomedical polyetheretherketone (PEEK) implants for enhancing biological functions is crucial and difficult due to its inherent chemical inertness. In this study, PEEK was fabricated by controllable sulfonation using gaseous sulfur trioxide (SO3) different time (5, 15, 30, 60 90 min). Micro-topological generated sulfonated preserving original mechanical properties. The protein absorption capacity apatite forming ability thus improved...

Electrical stimulation (ES) is therapeutic to many bone diseases, from promoting fracture regeneration orthopedic intervention. The application of ES offers substantial potential, while optimal parameters and the underlying mechanisms responsible for positive clinical impact are poorly understood. In this study, we assembled an cell culture monitoring device. Mc-3T3-E1 cells were subjected different frequency investigate effect osteogenesis. Cell proliferation, DNA synthesis, mRNA levels...

Electrically conducting polymers have been emerging as intelligent bioactive materials for regulating cell behaviors and bone tissue regeneration. Additionally, poor adhesion between conventional implants native may lead to displacement, local inflammation, unnecessary secondary surgery. Thus, a conductive bioadhesive with strong performance provides an effective approach fulfill fixation regeneration of comminuted fracture. Inspired by mussel chemistry, we designed the copolymers...

The overall aim of the current study is to develop a dual-functional PEEK implant simultaneously fight off bacterial contamination and promote osseointegration by sustained release moxifloxacin hydrochloride (MOX) osteogenic growth peptide (OGP) from mussel-inspired polydopamine (PDA)-coated porous sulfonated (SPK) surface. Our revealed that MOX/OGP PDA-modified SPK (SPD-MOX/OGP) surface exhibited durable excellent antibacterial effect against planktonic/adherent Staphylococcus aureus...

During the use and management of lead–acid batteries, it is very important to carry out prediction study state health (SOH) battery. To this end, paper proposes a SOH method for batteries based on CNN-BiLSTM-Attention model. The model utilizes convolutional neural network (CNN) feature extraction data dimension reduction in input factors model, then these are used as bidirectional long short-term memory (BiLSTM). BiLSTM learn temporal correlation information local features time series...

ABSTRACT Bone defect and osteochondral injury frequently occur due to diseases or traumatism bring a crucial challenge in orthopedics. The hybrid scaffold has shown promise as potential strategy for the treatment of such defects. In this study, novel biomimetic porous collagen (Col)/hydroxyapatite (HA) was fabricated through assembling layers Col containing gradual amount HA under assistance “iterative layering” freeze‐drying process. presents double gradient highly interconnected porosity...

Physicochemical properties of biomaterials play a regulatory role in osteoblast proliferation and differentiation. Inspired by the electrical natural bone, electroactive composites applied to osteogenesis have gradually become hotspot research. In this work, an biocomposite poly(lactic-co-glycolic acid) mixed with gadolinium-doped barium titanate nanoparticles (Gd-BTO NPs) was investigated establish structure–activity relationship between property, especially surface potential, osteogenic...

Wound healing is a complex process. Wound-repair materials require multiple functionalities, such as anti-inflammatory, antibacterial, angiogenesis, pro-proliferation, and remodeling. To achieve rapid tissue regeneration, magnetic field-assisted therapy has become promising means. In this study, homogeneous responsive nanocomposite hydrogel with enhanced mechanical properties was obtained through tannin (TA)-assisted bridge between magneto-deformable cobalt ferrite nanoparticles (CFO NPs)...

Using bone tissue engineering strategies to achieve defect repair is a promising modality. However, the process outcomes are often unsatisfactory. Here we properly designed multi-functional microsphere system, which could deliver bioactive proteins under dual response of ultrasound and microenvironment, release microenvironment-responsive products on demand, reverse injury regulate immune excellent treatment outcomes. In particular, MnO2 introduced into poly(lactic-co-glycolic acid) (PLGA)...

Polylactic acid (PLA) is one of the most promising candidates to solve present environmental and energy problems. The programmable three-dimensional (3D) fabrication technique also provides a convenient green platform for PLA applications in bone tissue engineering. An innovative scaffold that combined multiple functions including highly interconnected porosity, sufficient nutrient supply, antibacterial activity was prepared through 3D printing. Porosity 67%, which quite desirable cell...

Polyetheretherketone (PEEK), as the most promising implant material for orthopedics and dental applications, has bone-like stiffness, excellent fatigue resistance, X-ray transparency, near absence of immune toxicity. However, due to biological inertness, its bone conduction ingrowth performance is limited. The surface modification PEEK an option overcome these shortcomings retain favorable properties, especially when osseointegration desired. In this study, a simple reaction procedure was...