A5062604671- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Photoreceptor and optogenetics research
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- Axon Guidance and Neuronal Signaling
- Stress Responses and Cortisol
- Neuroscience of respiration and sleep
- Neural dynamics and brain function
- Bone Metabolism and Diseases
- Renal and Vascular Pathologies
- Cardiovascular Disease and Adiposity
- Cell Adhesion Molecules Research
- Terahertz technology and applications
- Genetic and Kidney Cyst Diseases
- Genetic Associations and Epidemiology
- Bone health and osteoporosis research
- Ovarian cancer diagnosis and treatment
- Bone Tissue Engineering Materials
- Ion channel regulation and function
University of Chinese Academy of Sciences
2020-2025
Nanjing University
2017-2025
Nanjing General Hospital of Nanjing Military Command
2019-2025
Shenzhen Institutes of Advanced Technology
2013-2025
Chinese Academy of Sciences
2014-2025
Harbin Institute of Technology
2025
Wuhan University
2005-2025
Guilin Medical University
2025
Emory University
2023-2025
Zhongnan Hospital of Wuhan University
2025
Abstract Strontium ranelate is a newly approved drug that can reduce the risk of vertebral fracture, which attributed to its dual function in increasing bone formation and decreasing resorption. Strontium-containing hydroxyapatite was also demonstrated stimulate osteoblast activity inhibit osteoclast activity. However, molecular mechanisms strontium underlying such beneficial effects were still not fully understood. In this study, we investigated on osteogenic differentiation human...
Degenerative disc disease (DDD) is a common which affects millions of people. Autograft the bone marrow derived mesenchymal stem cells (BMSCs) have been shown to ability arrest degeneration in rabbit and canine intervertebral discs. In this study, we used mouse model investigate mechanism arrest. BMSC from Egfp transgenic mice were injected into degenerated murine discs induced by annular puncture. We found that could progressive with significant regeneration nucleus pulposus (NP)....
Intervertebral disc degeneration has been widely studied in different animal models. To test the hypothesis that needle puncture could induce progressive biochemical and molecular changes murine discs, we established a mouse tail model to investigate pathogenesis mechanism of puncture-induced degeneration. Caudal discs tails were punctured using 31G gauge at controlled depth under microscopic guidance. The progress was evaluated by radiographic analysis height, histological grading...
Abstract Astrocytes provide neuroprotective effects against degeneration of dopaminergic (DA) neurons and play a fundamental role in DA differentiation neural stem cells. Here we show that light illumination astrocytes expressing engineered channelrhodopsin variant (ChETA) can remarkably enhance the release basic fibroblast growth factor (bFGF) significantly promote human embryonic cells (hESCs) vitro . Light activation transplanted substantia nigra (SN) also upregulates bFGF levels vivo...
Homeostasis of bone metabolism is regulated by the central nervous system, and mood disorders such as anxiety are associated with abnormalities, yet our understanding neural circuits regulating limited. Here, we demonstrate that chronic stress in crewmembers resulted decreased density elevated an isolated habitat mimicking a space station. We then used mouse model to GABAergic circuitry ventromedial hypothalamus (VMH) mediates stress–induced loss. show inputs dorsomedial VMH arise from...
Abstract The central nervous system has evolved to coordinate the regulation of both behavior response external environment and homeostasis energy expenditure. Recent studies have indicated dorsomedial ventromedial hypothalamus (dmVMH) as an important hub that regulates innate for coping stress. However, how dmVMH neurons control neuronal firing pattern regulate chronic stress-induced anxiety expenditure remains poorly understood. Here, we found enhanced activity in VMH after stress, which...
Abstract Podocyte damage mediated by in situ complement activation the glomeruli is a key factor pathogenesis of membranous nephropathy (MN), but molecular mechanism has not been fully elucidated. Pyroptosis special type programmed cell death, mediate inflammatory response and induce tissue injury. However, it clear whether pyroptosis involved development progression MN. Here, we report that plays an important role promoting podocyte injury We first observed occurrence kidneys MN patients...
Nonalcoholic fatty liver disease (NAFLD) affects a large population with incompletely defined mechanism(s). Here we report that Kindlin-2 is dramatically up-regulated in livers obese mice and patients NAFLD. haploinsufficiency hepatocytes ameliorates high-fat diet (HFD)-induced NAFLD glucose intolerance without affecting energy metabolism mice. In contrast, overexpression exacerbates promotes lipid disorder inflammation hepatocytes. A C-terminal region (aa 570-680) of binds to stabilizes...
ABSTRACT Background Parkinson's disease (PD) and Lewy body dementia (LBD) have many common features, including clinical manifestations, neurochemistry, pathology, but little is known about their shared brain proteins genetic factors. Methods To identify susceptibility‐related that are between PD LBD patients, proteome‐wide association studies (PWASs) were conducted by integrating human protein quantitative trait loci (pQTLs) with large‐scale genome‐wide (GWASs) of both diseases....
Alteration of podocyte behavior is critically involved in the development and progression many forms human glomerular diseases. The molecular mechanisms that control behavior, however, are not well understood. Here, we investigated role Kindlin-2, a component cell-matrix adhesions, vivo . Ablation Kindlin-2 podocytes resulted alteration actin cytoskeletal organization, reduction levels slit diaphragm proteins, effacement foot processes, ultimately massive proteinuria death due to kidney...
Neural firing patterns are critical for specific information coding and transmission, abnormal is implicated in a series of neural pathologies. Recent studies have indicated that enhanced burst mediated by T-type voltage-gated calcium channels (T-VGCCs) neuronal subtypes involved several mental or neurological disorders such as depression epilepsy, while suppression T-VGCCs relieve related symptoms. Burst consists groups relatively high-frequency spikes separated quiescence. Neurons variety...
Abstract Parathyroid hormone (PTH) plays crucial role in maintaining calcium and phosphorus homeostasis. In the progression of secondary hyperparathyroidism (SHPT), expression calcium-sensing receptors (CaSR) parathyroid gland decreases, which leads to persistent hypersecretion PTH. How precisely manipulate PTH secretion tissue underlying molecular mechanism is not clear. Here, we establish an optogenetic approach that bypasses CaSR inhibit human hyperplastic cells. We found stimulation...
Early weaning usually causes small intestine epithelial development abnormality, increasing the risk of gastrointestinal diseases. Glutamine (Gln), enriching in plasma and milk, is widely reported to benefit intestinal health. However, whether Gln affects stem cell (ISC) activity response early unclear. Here, both mice organoids were used study role regulating ISC activities. Results showed that ameliorated weaning-induced atrophy augmented ISC-mediated regeneration. deprivation disabled...
Abstract Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular maintains at aneural state. Neuron guidance factor Semaphorin 3A (Sema3A) membrane-associated secreted protein chemorepulsive properties for axons. However, role Sema3A in still not clear. In present studies, we investigated functions OA development mice, non-human primates, patients OA. has protective effect on degradation, validated by...
Each odontoblast is tightly linked to other odontoblasts. They form a line of defense and are capable withstanding external stimuli, particularly the inflammation caused by caries. Thus, we investigated exosomes derived from odontoblasts as an intercellular mechanism which inflamed protected apoptosis. CD63, exosome marker, was expressed at high levels in caries-affected regions dental pulp. We conducted ex vivo experiment applying different concentrations lipopolysaccharide (LPS)...