A5028166621- Endodontics and Root Canal Treatments
- dental development and anomalies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Oral microbiology and periodontitis research
- Cancer-related gene regulation
- Dental materials and restorations
- Bone and Dental Protein Studies
- Dental Radiography and Imaging
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Bone Metabolism and Diseases
- Oral and Maxillofacial Pathology
- Dental Implant Techniques and Outcomes
- Mesenchymal stem cell research
- Dental Erosion and Treatment
- Periodontal Regeneration and Treatments
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Dental Trauma and Treatments
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- RNA Research and Splicing
- Salivary Gland Disorders and Functions
Wuhan University
2016-2025
Army Medical University
2010-2025
Southwest Hospital
2024-2025
Zhejiang Chinese Medical University
2023-2025
University of South China
2025
Beijing University of Chinese Medicine
2024
Chinese Academy of Sciences
2013-2024
Dongguan People’s Hospital
2022-2024
Southern Medical University
2022-2024
Second Hospital of Shanxi Medical University
2016-2024
Hepatocellular carcinoma (HCC) displays high resistance to conventional chemotherapy. Considering that microRNA-122 (miR-122) performs an essential function promote chemosensitivity of HCC cells, effective vehicle-mediated miR-122 delivery may represent a promising strategy for An increasing interest is focused on the use exosomes as biological vehicles microRNAs (miRNA) transfer. Mesenchymal stem cells (MSCs) are known their capacity produce large amounts exosomes. This study aimed...
ABSTRACT Csx/Nkx2.5 is a vertebrate homeobox gene with sequence homology to the Drosophila tinman, which required for dorsal mesoderm specification. Recently, heterozygous mutations of this were found cause human congenital heart disease (Schott, J.-J., Benson, D. W., Basson, C. T., Pease, Silberbach, G. M., Moak, J. P., Maron, B. J., Seidman, E. and (1998) Science 281, 108-111). To investigate functions in cardiac extracardiac development vertebrate, we have generated analyzed mutant mice...
We have used a retroviral gene trap in embryonic stem (ES) cells to derive recessive lethal mouse strain, ROSA beta-geo5. Mutant embryos display an enlarged pericardial cavity, bradycardia, dilated fourth ventricle the brain, and die between days 11 12. Whereas heart development mutant is extensive, ventricular wall abnormally thin with reduced number of trabeculae. Cloning trapped indicates that proviral insertion creates null mutation transcriptional enhancer factor 1 (TEF-1) gene....
Antioxidants may protect normal cells from the oxidative damage that occurs during radiotherapy and certain chemotherapy regimens; however, same mechanism could tumor potentially reduce effectiveness of cancer treatments. We evaluated association vitamin supplement use in first 6 months after breast diagnosis treatment with total mortality recurrence.We conducted a population-based prospective cohort study 4,877 women aged 20 to 75 years diagnosed invasive Shanghai, China, between March 2002...
The clinical translation of regenerative endodontics demands further development suitable scaffolds. Here, we assessed the possibility using silk fibroin scaffold for pulp regeneration with dental stem cells (DPSCs) and basic fibroblast growth factor (bFGF) in ectopic root canal transplantation model. Porous scaffolds were fabricated freeze-drying technique (with or without bFGF incorporation), characterized by scanning electron microscopy (SEM) Fourier transform infrared spectroscopy. DPSCs...
The elucidation of the molecular mechanisms that govern differentiation bone marrow stromal cells (BMSCs) could provide new insight into treatment loss diseases. MicroRNAs (miRNAs) are small non‐coding RNAs regulate gene expression during stem cell growth, proliferation, and differentiation. In present study, we showed miR‐338‐3p was significantly down‐regulated osteoblastic BMSCs. Additionally, up‐regulated in ovariectomized (OVX) mice compared with sham mice. An vitro analysis revealed...
Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator interferon genes (STING) pathway activation in infectious diseases. Odontoblasts are first cells challenged by cariogenic bacteria and involved maintenance pulp immune inflammatory responses dentine-invading pathogens. In this study, we investigated that as an important participated defending against...
Abstract Background Artificial intelligence (AI) has been introduced to interpret the panoramic radiographs (PRs). The aim of this study was develop an AI framework diagnose multiple dental diseases on PRs, and initially evaluate its performance. Methods developed based 2 deep convolutional neural networks (CNNs), BDU-Net nnU-Net. 1996 PRs were used for training. Diagnostic evaluation performed a separate dataset including 282 PRs. Sensitivity, specificity, Youden’s index, area under curve...
Abstract Background Molecular classification of breast cancer is an important prognostic factor. The distribution molecular subtypes and their value has not been well documented in Asians. Methods A total 2,791 patients recruited for a population-based cohort study were evaluated by immunohistochemical assays. Data on clinicopathological characteristics confirmed centralized pathology review. average follow-up the was 53.4 months. Overall disease-free survival evaluated. Results prevalence...
Understanding patterns of shared and type-specific etiologies for colorectal polyps may provide insights into carcinogenesis. The authors present the first systematic comparison risk factors by polyp type in a large colonoscopy-based case-control study 3,764 polyp-free controls 2,543 patients, including 1,444 cases with adenomas only, 662 hyperplastic (HPPs) 437 synchronous HPPs adenomas. Surveys were completed to obtain information on usual dietary intake other lifestyle factors. Six...