A5012993508- Wound Healing and Treatments
- Hair Growth and Disorders
- Mesenchymal stem cell research
- Connective Tissue Growth Factor Research
- Dermatologic Treatments and Research
- TGF-β signaling in diseases
- Angiogenesis and VEGF in Cancer
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Healthcare and Venom Research
- Dyeing and Modifying Textile Fibers
- Graphene and Nanomaterials Applications
- Corneal Surgery and Treatments
- Molecular Biology Techniques and Applications
- Silk-based biomaterials and applications
- Biomedical Ethics and Regulation
- Advanced Nanomaterials in Catalysis
- Diabetic Foot Ulcer Assessment and Management
- Fibroblast Growth Factor Research
- Medical Research and Treatments
- Skin Protection and Aging
- Nanoplatforms for cancer theranostics
- Proteoglycans and glycosaminoglycans research
- Pharmacological Effects of Medicinal Plants
The First Affiliated Hospital, Sun Yat-sen University
2008-2025
Sun Yat-sen University
2008-2025
Abstract The protracted transition from inflammation to proliferation in diabetic wound healing poses significant challenges, exacerbated by persistent inflammatory responses and inadequate vascularization. To address these issues, a novel nanozymatic therapeutic approach utilizing asymmetrically structured MnO₂–Au–mSiO₂@aFGF Janus nanoparticles is engineered. Nanozymes featuring mSiO₂ head MnO₂ extensions, into which acidic fibroblast growth factor (aFGF) encapsulated, resulting...
Background The treatment of diabetic foot ulcers (DFUs) poses a challenging medical problem that has long plagued individuals with diabetes. Clinically, wounds fail to heal for more than 12 weeks after the formation DFUs are referred as non-healing/chronic wounds. Among various factors contributing non-healing DFUs, impairment skin microvascular endothelial cell function caused by high glucose plays crucial role. Our study aimed reveal transcriptomic signatures cells, providing novel...
Hypertrophic scar (HS) is a common fibroproliferative disorders with no fully effective treatments. The conversion of fibroblasts to myofibroblasts known play critical role in HS formation, making it essential identify molecules that promote myofibroblast dedifferentiation and elucidate their underlying mechanisms. In this study, we used comparative transcriptomics single-cell sequencing key pathways mediate fibrosis transdifferentiation. Epidermal stem cell-derived extracellular vesicles...
Smad proteins are important intracellular mediators of transforming growth factor (TGF)-beta signaling. Little has been known about the specific relationship between TGF-beta and TGF-beta/Smad signaling in hypertrophic scars.The objective was to investigate expression Smads scars.In this study, we initially determined endogenous protein levels Smad2 Smad7 scar fibroblast (HSFs) normal skin (NSFs). Second, stimulated HSFs NSFs with recombinant human TGF-beta1 for 24 hours determine whether...
BACKGROUND Smad proteins are important intracellular mediators of transforming growth factor (TGF)-β signaling. Little has been known about the specific relationship between TGF-β and TGF-β/Smad signaling in hypertrophic scars. OBJECTIVE The objective was to investigate expression Smads METHODS In this study, we initially determined endogenous protein levels Smad2 Smad7 scar fibroblast (HSFs) normal skin (NSFs). Second, stimulated HSFs NSFs with recombinant human TGF-β1 for 24 hours...
Background: N6-methyladenosine (m 6 A) is the most common and abundant mRNA modification, playing an essential role in biological processes tumor development.However, of m A methylation skin cutaneous melanoma (SKCM) not yet clear.This study analyzed expression A-related functional genes SKCM aimed to explore key demethylase ALKBH5 mediated modification its potential mechanism human SKCM.Methods: Based on public databases, gene landscape was portrayed.MeRIP-Seq RNA-Seq were used recognize...
Background: Basic fibroblast growth factor (bFGF) was clinically proven to accelerate acute and chronic wound healing. Accelerated healing may lead improved scarring. These studies suggested a possible antiscarring effect of bFGF during Little known about the precise pathologic mechanisms on scarring formation. Aims: The aim this study investigate hypertrophic in rabbit ear model clarify mechanism scar treatment. Methods: created received low- or high-dose topical treatment three times daily...