A5101461614- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Nonlinear Partial Differential Equations
- Tuberculosis Research and Epidemiology
- Mathematical Biology Tumor Growth
- Advanced Mathematical Modeling in Engineering
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Liver Diseases and Immunity
- SARS-CoV-2 and COVID-19 Research
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Kruppel-like factors research
- Vasculitis and related conditions
- Nonlinear Differential Equations Analysis
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Pneumonia and Respiratory Infections
- Microtubule and mitosis dynamics
- Spectral Theory in Mathematical Physics
- Bacterial Infections and Vaccines
- Virus-based gene therapy research
- Infectious Diseases and Tuberculosis
Huazhong University of Science and Technology
2020-2024
Tongji Hospital
2020-2024
Jiangxi Normal University
2013-2024
Hengyang Normal University
2024
Fourth Affiliated Hospital of Harbin Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
The Ohio State University Wexner Medical Center
2011-2023
The Ohio State University
2004-2021
China Medical University
2017-2020
Southwest Minzu University
2020
The purpose of this study was to evaluate urine monocyte chemoattractant protein-1 (MCP-1) and IL-8 as biomarkers SLE flare. Urine collected every 2 mo from patients who were followed prospectively in the Ohio Study. Renal nonrenal flares identified MCP-1 measured by specific ELISA samples that at When available, also before after For comparison, healthy individuals renal with stable disease activity (disease controls). Most receiving maintenance immunosuppressive therapy At flare, mean...
To study the sensitivity and specificity of vitamin D deficiency for predicting disease activity damage systemic lupus erythematosus (SLE) in comparison with anti-dsDNA anti-C1q.Consecutive patients who fulfilled four or more ACR criteria SLE were studied. Levels 25-hydroxyvitamin D3, anti-C1q, complement levels measured. Relationship among these markers, concurrent scores was studied by Spearman's rank correlation method.In total, 290 (95% women; mean age 38.9 ± 13.1 years; duration 7.7 6.7...
Oxidant stress can initiate or enhance inflammatory responses during tissue injury, possibly through activation of redox-sensitive chemokines. Because the transcription factor Nrf2 (NF-E2-related 2) is responsive to oxidative stress, and induces expression cytoprotective antioxidant genes that attenuate we postulated may also regulate chemokine expression. To test this hypothesis, was directly increased in primary human kidney mesangial cells aortic endothelial cells, cell lines with an...
Managing with diabetic foot osteomyelitis (DFO) is challenging. Even after infective bone resection and thorough debridement, DFO still difficult to cure has a high recurrence rate. This retrospective study aims compare the outcomes of two treatment methods, infected combined adjuvant antibiotic-impregnated calcium sulfate alone, for osteomyelitis. Between 2015 2017, 48 limbs (46 patients) met criteria were included assessment. 20 (18 in group (the CS group) which vancomycin and/or...
Cross-sectional studies have shown that low vitamin D (25-hydroxyvitamin (25(OH)D)) is associated with increased systemic lupus erythematosus (SLE) activity. This study the first to assess temporal relationship between 25(OH)D levels and onset of SLE flare. assessment was made possible because specimen bank database Ohio Study (OSS), a longitudinal frequently relapsing involved regular bimonthly patient follow-up. We identified for this 82 flares from 46 patients were separated by at least 8...
Abstract Background We have reported previously that overexpression of glucose-regulated protein 78 (GRP78) promotes the invasion hepatocellular carcinoma. However, whether GRP78 knockdown affects extracellular matrix degradation has not been elucidated. Here we are going to determine affect ECM and role MMP-2 MMP-9 in these process carcinoma cells. Methods Human cell line SMMC7721 HepG2 were cultured DMEM supplemented with 10% FBS, RT-PCR western blot used detect endogenous expression...
The kidney biopsy is used to diagnose and guide initial therapy in patients with lupus nephritis (LN). Kidney histology does not correlate well clinical measurements of injury or predict how will respond standard-of-care immunosuppression. We postulated that the gene expression profile tissue at time may differentiate who from those treatment.The 511 immune-response genes was measured biopsies 19 proliferative LN 4 normal controls. RNA extracted formalin-fixed, paraffin-embedded done flare....
Objective To evaluate candidate biomarkers to predict future renal function decline (RFD) in children and adults with lupus nephritis (LN). Methods At the time of enrollment into prospective observational LN cohort studies liver-type fatty acid binding protein (LFABP), albumin, monocyte chemoattractant protein-1 (MCP-1), uromodulin, transferrin, hepcidin were measured urine samples two cohorts patients LN, one followed at a pediatric (cohort-1; n = 28) an adult institution (cohort-2; 69)....
Abstract Background There are currently rare satisfactory markers for predicting the death of patients with coronavirus disease 2019 (COVID-19). The aim this study is to establish a model based on combination serum cytokines and lymphocyte subsets prognosis disease. Methods A total 739 participants COVID-19 were enrolled at Tongji Hospital from February April 2020 classified into fatal ( n = 51) survived 688) groups according patient’s outcome. Cytokine profile subset analysis was performed...
BackgroundDiscriminating active tuberculosis (ATB) from latent infection (LTBI) remains challenging. The present study aims to evaluate the performance of diagnostic models established using machine learning based on routine laboratory indicators in differentiating ATB LTBI.MethodsParticipants were respectively enrolled at Tongji Hospital (discovery cohort) and Sino-French New City (validation cohort). Diagnostic learning.ResultsA total 2619 participants (1025 1594 LTBI) discovery cohort...
Abstract Background Up to 50% of lupus nephritis (LN) patients experience renal flares after their initial episode LN. These contribute poor outcomes. We postulated that intrarenal immune gene expression is different in compared with de novo LN, and conducted these studies test this hypothesis. Methods Glomerular tubulointerstitial was evaluated 14 who had a kidney biopsy diagnose LN another at first flare. Ten healthy living donors were included as controls. RNA extracted from laser...
BackgroundThe differential diagnosis between novel coronavirus pneumonia patients (NCPP) and influenza (IP) remains a challenge in clinical practice.MethodsBetween January 2018 March 2020, 1,027 NCPP 1,140 IP were recruited from Tongji hospital. Routine blood examination, biochemical indicators coagulation function analysis simultaneously performed all participants.ResultsThere was no sex predominance NCPP. The frequently encountered the sixth seventh decades of life. mean age (56 ± 16...