A5100600688- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- COVID-19 and Mental Health
- Mental Health Research Topics
- Neuropeptides and Animal Physiology
- Neural and Behavioral Psychology Studies
- Sepsis Diagnosis and Treatment
- Heat shock proteins research
- MicroRNA in disease regulation
- Treatment of Major Depression
- Mental Health Treatment and Access
- Tryptophan and brain disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Receptor Mechanisms and Signaling
- Healthcare professionals’ stress and burnout
- Liver Disease Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Attention Deficit Hyperactivity Disorder
- Erythropoietin and Anemia Treatment
- Blood transfusion and management
Affiliated Hospital of Jiangsu University
2015-2025
First People's Hospital of Yunnan Province
2016-2025
Kunming University of Science and Technology
2016-2025
Guangxi University
2025
Soochow University
2024-2025
Shanghai University of Medicine and Health Sciences
2025
Shanghai University of Traditional Chinese Medicine
2025
Jiangsu University
2015-2025
Anhui Medical University
2016-2024
Anhui Mental Health Center
2014-2024
Abstract Artificial optoelectronic synapses with both electrical and light‐induced synaptic behaviors have recently been studied for applications in neuromorphic computing artificial vision systems. However, the combination of visual perception high‐performance information processing capabilities still faces challenges. In this work, authors demonstrate a memristor based on 2D bismuth oxyiodide (BiOI) nanosheets that can exhibit bipolar resistive switching (RS) performance as well plasticity...
Abstract Background Although the immune function of neutrophils in sepsis has been well described, heterogeneity remains unclear during process sepsis. Methods In this study, we used a mouse CLP model to simulate clinical scenario patients with sepsis, neutrophil infiltration, abnormal distribution and dysfunction was analyzed. LPS stimulate vitro sepsis; single-cell gene sequencing technology explore immunological typing. To immunosuppressive neutrophils, PD-L1 knockout were cocultured...
Background: Serum exosome-based liquid biopsy has significant advantages for screening and diagnosing hepatocellular carcinoma (HCC). P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are novel small silencing that have been identified to function in cancer-related signalling pathways. However, studies on the presence of piRNAs serum exosomes from HCC patients their diagnostic values not well reported. Our aim is validate exosome-derived as valuable component HCC. Methods: We...
Abstract Cancer-associated fibroblasts (CAFs), the main stromal component of tumor microenvironment (TME), play multifaceted roles in cancer progression through paracrine signaling, exosome transfer, and cell interactions. Attractively, recent evidence indicates that CAFs can modulate various forms regulated death (RCD) adjacent cells, thus involving proliferation, therapy resistance, immune exclusion. Here, we present a brief introduction to basic knowledge RCD, including apoptosis,...
Extracellular 5‐hydroxytryptamine (5‐HT) was determined in dorsal raphe nucleus (DRN), median (MRN) and accumbens by use of microdialysis unanaesthetized rats. Infusion the γ‐aminobutyric acid (GABA) A receptor agonist muscimol into DRN MRN resulted decreased 5‐HT MRN, respectively. Muscimol infusion had no effect on 5‐HT. GABA antgonist bicuculline increased Bicuculline This suggests that endogenous a tonic, receptor‐mediated inhibitory DRN, but not MRN. B baclofen produced decrease...
Objective: This study aimed to evaluate the anti-inflammatory effects of petal and stamen extracts saffron crocus ( Crocus sativus ) explore underlying mechanism. Methods: Local systemic inflammation models were used investigate C. sativus. A xylene-induced model or lipopolysaccharide (LPS)-induced was in this study. each administered mice xylene LPS by gavage for 14 d at 0.1 0.4 g/kg doses, respectively. Enzyme-linked immunosorbent assay (ELISA) measure concentrations tumor necrosis factor...
Opioid receptor subtypes may have site-specific effects and play different roles in modulating serotonergic neurotransmission the mammalian central nervous system. To test this hypothesis, we used vivo microdialysis to measure changes extracellular serotonin (5-hydroxytryptamine; 5-HT) response local infusion of μ-, δ-, κ-opioid ligands into dorsal raphe nucleus (DRN), median (MRN), accumbens (NAcc) freely behaving rats. The μ-opioids...
Although individuals with autism spectrum disorders (ASD) and schizophrenia (SCH) share overlapping characteristics may perform similarly on many cognitive tasks, dysfunctions common to both do not necessarily the same underlying mechanisms. Decision-making is currently a major research interest for ASD SCH. The aim of present study was make direct comparisons decision-making disorder-specific neuropsychological mechanisms between two disorders. Thirty-seven participants ASD, 46 patients...
Managing with diabetic foot osteomyelitis (DFO) is challenging. Even after infective bone resection and thorough debridement, DFO still difficult to cure has a high recurrence rate. This retrospective study aims compare the outcomes of two treatment methods, infected combined adjuvant antibiotic-impregnated calcium sulfate alone, for osteomyelitis. Between 2015 2017, 48 limbs (46 patients) met criteria were included assessment. 20 (18 in group (the CS group) which vancomycin and/or...
Systemic administration of selective serotonin reuptake inhibitors (SSRIs) elicits larger increases in (5-HT) raphe than forebrain sites. Because serotonergic neuronal activity is suppressed, the mechanism underlying SSRI-induced extracellular 5-HT unclear. This study determined whether local infusion SSRIs also elicited regionally 5-HT, and changes depended on depolarization. Conventional microdialysis methods were used to measure dorsal (DRN), median raphe, nucleus accumbens (NAcc),...
The effect of morphine on serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the CNS unanesthetized rats was investigated by microdialysis. Morphine administered either subcutaneously, local perfusion into diencephalon, or intraraphe microinjection. Systemic administration resulted a significant increase both extracellular 5-HT 5-HIAA diencephalon. dose dependent during diencephalon with inhibitors uptake monoamine oxidase. also produced increases striatum hippocampus inhibition....
Abstract The effect of morphine on serotonin (5‐HT) was examined by microdialysis in unanesthetized and anesthetized rats. In rats, (10 mg/kg, s. c.) produced increases extracellular 5‐HT nucleus accumbens (n. accumbens) dorsal raphe (DRN), but not the hippocampus. Similarly, n. accumbens, hippocampus, increased after (1 μM) infused for 60 min reverse dialysis into DRN. Chloral hydrate, pentobarbital, ketamine anesthesia had different effects accumbens. hydrate induced a transient increase...
Serum exosomes are emerging as key liquid biopsy biomarkers for the early diagnosis of cancer. However, proportion and distribution small RNA (sRNA) species from serum hepatocellular carcinoma (HCC) patients remain unclear. Effective reliable HCC should be explored.In this study, we aimed to use sRNA sequencing profile sRNAs in non-tumor donors. The 124 46 donors were enrolled detecting values potential HCC.We found that miRNAs accounted maximal percentage all types both This indicated...
Abstract: The contribution of NMDA receptors to regulation serotonin (5‐HT) release was assessed by in vivo microdialysis freely behaving rats. During infusion (30, 100, and 300 µ M ) into the dorsal raphe nucleus (DRN), 5‐HT increased ∼25, 280%, respectively. Competitive noncompetitive NMDA‐receptor antagonists blocked this effect on DRN 5‐HT. Infusion (300 also produced an 80% increase extracellular accumbens. (100 median (MRN), ∼15 80%, MRN a significant hippocampal In contrast,...