A5103222487- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- SARS-CoV-2 detection and testing
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- T-cell and B-cell Immunology
- Animal Virus Infections Studies
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- COVID-19 diagnosis using AI
- Virus-based gene therapy research
- Influenza Virus Research Studies
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- COVID-19 Impact on Reproduction
- Immune Response and Inflammation
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Galectins and Cancer Biology
- Salmonella and Campylobacter epidemiology
- Autoimmune and Inflammatory Disorders Research
- Radiomics and Machine Learning in Medical Imaging
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
China Medical University Hospital
2025
China Medical University
2025
Animal Science Research Institute
2015-2024
Anhui Academy of Agricultural Sciences
2015-2024
Poultry Research Institute
2022-2023
Xinxiang Medical University
2022
Ningbo University
2021
Gansu University of Traditional Chinese Medicine
2019
Background Chest CT is used in the diagnosis of coronavirus disease 2019 (COVID-19) and an important complement to reverse-transcription polymerase chain reaction (RT-PCR) tests. Purpose To investigate diagnostic value consistency chest as compared with RT-PCR assay COVID-19. Materials Methods This study included 1014 patients Wuhan, China, who underwent both tests between January 6 February 6, 2020. With use reference standard, performance COVID-19 was assessed. In addition, for multiple...
BACKGROUNDThe coronavirus disease 2019 (COVID-19), infected by severe acute respiratory syndrome 2 (SARS-CoV-2), has caused a outbreak throughout the world. The host immunity of COVID-19 patients is unknown.METHODSThe routine laboratory tests and in with different severity illness were compared after patient admission.RESULTSA total 65 SARS-CoV-2-positive classified as having mild (n = 30), 20), extremely 15) illness. Many tests, such ferritin, lactate dehydrogenase, D-dimer, increased...
This study aimed to determine the IgM and IgG responses against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in disease 2019 (COVID-19) patients with varying illness severities.IgM antibody levels were assessed via chemiluminescence immunoassay 338 COVID-19 patients.IgM increased during first week after SARS-CoV-2 infection, peaked 2 weeks then reduced near-background most patients. was detectable 1 maintained at a high level for long period. The positive rates of and/or...
Abstract Background The impacts of chronic airway diseases on coronavirus disease 2019 (COVID‐19) are far from understood. Objective To explore the influence asthma and obstructive pulmonary (COPD) comorbidity expression outcomes, potential underlying mechanisms in COVID‐19 patients. Methods A total 961 hospitalized patients with a definite clinical outcome (death or discharge) were retrospectively enrolled. Demographic information extracted medical records. Lung tissue sections suffering...
To fully decipher the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein, it is essential to assess which part highly immunogenic in a systematic way. We generate linear epitope landscape protein by analyzing serum immunoglobulin G (IgG) response 1,051 disease 2019 (COVID-19) patients with peptide microarray. reveal two regions rich epitopes, i.e., C-terminal domain (CTD) and region close S2′ cleavage site fusion peptide. Unexpectedly, we find that...
Summary Effective laboratory markers for the estimation of disease severity and predicting clinical progression coronavirus disease-2019 (COVID-19) is urgently needed. Laboratory tests, including blood routine, cytokine profiles infection markers, were collected from 389 confirmed COVID-19 patients. The included patients classified into mild (n = 168), severe 169) critical groups 52). leukocytes, neutrophils, biomarkers [such as C-reactive protein (CRP), procalcitonin (PCT) ferritin]...
Objective: The clinical course of COVID-19, as well the immunological reaction, is notable for its extreme variability. Identifying main associated factors might help understand disease progression and physiological status COVID-19 patients. dynamic changes antibody against Spike protein are crucial understanding immune response. This work explores a temporal attention (TA) mechanism deep learning to predict severity, outcomes, levels by screening serological indicators over time. Methods:...
Human NK cells display extensive phenotypic and functional heterogeneity among healthy individuals, but the mechanism responsible for this variation is still largely unknown. Here, we show that a novel immune receptor, T-cell immunoglobulin ITIM domain (TIGIT), expressed preferentially on human shows wide in its expression levels individuals. We found TIGIT level related to of cells, from individuals can be divided into three categories according expression. with low higher cytokine...
Diarrhea is the leading infectious cause of childhood morbidity and mortality. Among bacterial agents, diarrheagenic Escherichia coli (DEC) major causal agent diarrhea in developing countries, particularly children under age 5 years. Here, we performed a hospital-based prospective study to explore pathotype distribution, epidemiological characteristics antibiotic resistance patterns DEC from < 5-year-old diarrheal children. Between August 2015 September 2016, 684 stool samples were collected...
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks especially in those patients without comorbidities, not fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude with selected yet symptoms ranging asymptomatic critically ill. Using integrative analysis genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, report...
Abstract Antibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of antibody regulated immune mediated through the Fc fragment. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered ADCC contributes COVID-19 disease development is currently not well understood. To understand potential correlation between and development, we analyzed activity neutralizing response in 255 individuals ranging from asymptomatic fatal infections over 1 year...
Salt is one of the main factors limiting use mudflats. In this study, yield, quality, and mineral content rice seeds under salt stress were investigated. A pot experiment was conducted with Yangyugeng2, Xudao9, Huageng5 0, 17.1, 25.6, 34.2 mM NaCl concentration treatments. The results showed that can significantly decrease panicle number, grain number per panicle, 1000-grain weight yield rice, among other things cause loss saline conditions. When less than NaCl, increases brown rate milled...
Accurate monitoring of host immunity is hampered by the flaws conventional tests.The relationship between lymphocyte number and function unknown.The lymphocytes was analyzed based on IFN-γ secretion assay.Lymphocyte investigated in individuals under various states.The CD4 + CD8 T cells gradually decreased, whereas them increased with increasing age.A significantly negative correlation existed both cells.Differently, NK are maintained at a high level after birth.Staying up all night found to...
Abstract Serological tests play an essential role in monitoring and combating the COVID-19 pandemic. Recombinant spike protein (S protein), especially S1 protein, is one of major reagents used for serological tests. However, high cost S production possible cross-reactivity with other human coronaviruses pose unavoidable challenges. By taking advantage a peptide microarray full coverage, we analyzed 2,434 sera from 858 patients, 63 asymptomatic patients 610 controls collected multiple...
Understanding the complexities of immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key gain insights into durability protective immunity against reinfection.We sought evaluate SARS-CoV-2 in convalescent patients with longer follow-up time.SARS-CoV-2-specific humoral and cellular responses were assessed disease 2019 (COVID-19) at 1 year postinfection.A total 78 COVID-19 (26 moderate, 43 severe, 9 critical) recruited after recovery. The positive rates both...
The immunogenicity of the SARS-CoV-2 proteome is largely unknown, especially for non-structural proteins and accessory proteins. In this study, we collect 2,360 COVID-19 sera 601 control sera. We analyze these on a protein microarray with 20 SARS-CoV-2, building an antibody response landscape immunoglobulin (Ig)G IgM. Non-structural NSP1, NSP7, NSP8, RdRp, ORF3b, ORF9b elicit prevalent IgG responses. patterns dynamics non-structural/accessory are different from those S N responses against...
B-lymphocyte hyperactivity in systemic lupus erythematosus (SLE) is T-cell-dependent, and CD4+ T-cell activation essential to SLE pathogenesis. However, the mechanism of deregulation T cells largely unknown. immunoglobulin ITIM domain (TIGIT) a new inhibitory receptor preferentially expressed on activated cells. Here, we address role TIGIT pathogenesis SLE. Our results showed that expression was significantly elevated patients with highly correlated activity disease. TIGIT+ from both healthy...
Salmonella is one of the most important zoonotic pathogens that can cause both acute and chronic illnesses in poultry flocks, also be transmitted to humans from infected poultry. The purpose this study was investigate prevalence, antimicrobial resistance, molecular characteristics isolated diseased clinically healthy chickens Anhui, China. In total, 108 isolates (5.66%) were successfully recovered chicken samples (n = 1908), including pathological tissue (57/408, 13.97%) cloacal swabs...