A5101566010- Orthodontics and Dentofacial Orthopedics
- Bone Tissue Engineering Materials
- Temporomandibular Joint Disorders
- Dental Implant Techniques and Outcomes
- Dental Radiography and Imaging
- dental development and anomalies
- Cleft Lip and Palate Research
- Bone and Dental Protein Studies
- Facial Rejuvenation and Surgery Techniques
- Graphene and Nanomaterials Applications
- Craniofacial Disorders and Treatments
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Facial Nerve Paralysis Treatment and Research
- Oral microbiology and periodontitis research
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Periodontal Regeneration and Treatments
- 3D Printing in Biomedical Research
- Calcium Carbonate Crystallization and Inhibition
- Laser Applications in Dentistry and Medicine
- Facial Trauma and Fracture Management
- Reconstructive Surgery and Microvascular Techniques
- NF-κB Signaling Pathways
- Laser-Ablation Synthesis of Nanoparticles
Shanghai Ninth People's Hospital
2015-2025
Shanghai Jiao Tong University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
National Clinical Research
2022
Huazhong University of Science and Technology
2016-2020
Tongji Hospital
2016-2020
Shanghai Municipal Commission of Health and Family Planning
2019
Indiana University School of Medicine
2016
Shanghai Municipal Education Commission
2013
Tianjin Medical University
2000
Summary Effective laboratory markers for the estimation of disease severity and predicting clinical progression coronavirus disease-2019 (COVID-19) is urgently needed. Laboratory tests, including blood routine, cytokine profiles infection markers, were collected from 389 confirmed COVID-19 patients. The included patients classified into mild (n = 168), severe 169) critical groups 52). leukocytes, neutrophils, biomarkers [such as C-reactive protein (CRP), procalcitonin (PCT) ferritin]...
Periodontitis is a chronic infectious disease caused by bacterial irritation. As an essential component of the host immunity, macrophages are highly plastic and play crucial role in inflammatory response. An appropriate timely transition from proinflammatory (M1) to anti-inflammatory (M2) indispensable for treating periodontitis. M2 macrophage-derived exosomes (M2-exos) can actively target sites modulate immune microenvironments, M2-exos effectively treat Excessive endoplasmic reticulum...
Abstract It is a big challenge for bone healing under osteoporotic pathological condition with impaired angiogenesis, osteogenesis and remodeling. In the present study, effect of Ca, Mg, Si containing akermanite bioceramics (Ca 2 MgSi O 7 ) extract on cell proliferation, osteogenic differentiation angiogenic factor expression BMSCs derived from ovariectomized rats (BMSCs-OVX) as well osteoclastogenic factors was evaluated. The results showed that could enhance ALP activity, Runx2, BMP-2,...
Immune reactions are a key factor in determining the destiny of bone substitute materials after implantation. Macrophages, most vital immune response affecting implants, critical formation, as well biomaterial-mediated repair. Therefore, it is to design with osteoimmunomodulatory properties reduce host-to-material inflammatory responses by inducing macrophage polarization. Our previous study showed that calcium silicate (CS) bioceramics could significantly promote osteogenesis. Herein, we...
Bone tissue engineering offers a possible strategy for regenerating large bone defects, in which how to design beneficial scaffolds accelerating formation remains significantly challenging. Europium, as an important rare earth element, has been used solid-state lighting material. However, there are few reports on whether Eu can be labeling scaffolds, and its biological effect cells regeneration is unknown. In this study, we incorporated into mesoporous bioactive glass (Eu-MBG) by situ...
Control over the morphology and chemical composition of hydroxyapatite (HAp) bioceramic scaffolds is great importance for their applications. In present study, Si-substituted HAp with controllable morphologies (nanosheets nanorods) were fabricated via hydrothermal treatment calcium silicate as precursors in NaH2PO4 Na3PO4 aqueous solutions, respectively. Moreover, effects surface Si substitution on cell attachment, proliferation, osteogenic differentiation rat bone marrow stromal cells...
Periodontitis, an inflammatory bone resorption disease associated with dental plaque, poses significant challenges for effective treatment. In this study, we developed Mino@ZIF-8 nanoparticles inspired by the periodontal microenvironment and unique properties of zeolitic imidazolate framework 8, aiming to address complex pathogenesis periodontitis. Transcriptome analysis revealed active engagement in innate adaptive host defense cellular metabolic remodeling. Through sustained release...
Severe periodontitis frequently leads to irreversible degradation of alveolar bone. Periodontal regeneration techniques hold immense potential in reconstructing bone post periodontal diseases. Schwann cells (SCs) play a critical role supporting, maintaining, and regenerating tissues, with SC-derived exosomes (SC-EXO) exhibiting cell homing tissue repair capabilities. Nevertheless, the specific SC-EXO remains unknown. To address issue, we treated human ligament (hPDLCs) observed notable...
The surgery-first approach (SFA), without presurgical orthodontic treatment, has become favoured in the treatment of dentomaxillofacial deformities. This been applied our institution since 2012. purpose this study was to report experience with SFA for skeletal malocclusion. Fifty patients malocclusions were enrolled (11 bimaxillary protrusion, 27 class III malocclusion, and 12 facial asymmetry). After orthognathic-orthodontic consultation, suitability determined a plan drawn up. Patients...
The repair of tissue defects has attracted considerable attention and remained a substantial challenge. Calcium silicate (CaSiO3, CS) bioceramics have the interest researchers due to their excellent biodegradability. Recent studies demonstrated that nanoscale-modified bioactive materials with favorable biodegradability could promote bone regeneration, providing an alternative approach for defects. However, direct construction biodegradable nanostructures in situ on CS was still difficult.In...
Blood vessels and nerve fibers are distributed throughout the skeletal tissue, which enhance development function of each other have an irreplaceable role in bone formation remodeling. Despite significant progress tissue engineering, inadequacy nerve-vascular network reconstruction remains a major limitation. This is partly due to difficulty integrating regulating multiple types with artificial materials. Thus, understanding anatomy underlying coupling mechanisms blood within further develop...
An important limitation of the T-SPOT(®).TB assay is its inability to distinguish active tuberculosis (TB) from latent tuberculous infection (LTBI).We proposed a new calculation method for T-SPOT and assessed effect on distinguishing TB LTBI.A total 162 patients 97 LTBI individuals were diagnosed according conventional tests assay.The results early secreted antigenic target 6 (ESAT-6) culture filtrate protein 10 (CFP-10) in cannot be recommended LTBI. The number phytohaemagglutinin (PHA)...
Objective The objective of this study was to evaluate changes in soft tissue full-face view because surgical correction skeletal Class III malocclusion, using 3-dimensional (3D) laser scanning. Methods Twenty-seven subjects with malocclusion [11 males; mean age (SD), 24.0 (5.7) years] underwent bilateral sagittal split ramus osteotomy for mandibular setback combined Lefort I with/without maxillary advancement. Twelve patients (group 1) had surgery, and the other 15 2) combination surgery....
Structured Abstract Objective This study evaluated the relationship between follow‐up temporomandibular joint positional change and mandibular stability among patients who had orthognathic orthodontic treatment for a skeletal Class II malocclusion. Methods Thirty‐seven underwent 2‐jaw surgery (Le Fort I osteotomy, bilateral sagittal split ramus osteotomy genioplasty with rigid internal fixation) were included an average length of 8.10 ± 2.06 years. They categorized into stable unstable group...