A5047344139- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Traditional Chinese Medicine Analysis
- Airway Management and Intubation Techniques
- Chemokine receptors and signaling
- RNA Research and Splicing
- Immune cells in cancer
- MicroRNA in disease regulation
- Congenital Diaphragmatic Hernia Studies
- Single-cell and spatial transcriptomics
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- RNA Interference and Gene Delivery
- COVID-19 and healthcare impacts
- Tracheal and airway disorders
- Phytochemicals and Antioxidant Activities
- Viral gastroenteritis research and epidemiology
Tongji Hospital
2011-2025
Huazhong University of Science and Technology
2011-2024
University of Science and Technology of China
2021-2024
University of Electronic Science and Technology of China
2021
University of Chinese Academy of Sciences
2021
Jinyintan Hospital
2021
Union Hospital
2020
Zhejiang Cancer Hospital
2019
Jeonbuk National University
2010-2011
Universitätsklinik für Chirurgie Wien
2000
BACKGROUNDThe coronavirus disease 2019 (COVID-19), infected by severe acute respiratory syndrome 2 (SARS-CoV-2), has caused a outbreak throughout the world. The host immunity of COVID-19 patients is unknown.METHODSThe routine laboratory tests and in with different severity illness were compared after patient admission.RESULTSA total 65 SARS-CoV-2-positive classified as having mild (n = 30), 20), extremely 15) illness. Many tests, such ferritin, lactate dehydrogenase, D-dimer, increased...
Objectives: Coronavirus disease 2019 has emerged as a major global health threat with great number of deaths in China. We aimed to assess the association between Acute Physiology and Chronic Health Evaluation II score hospital mortality patients coronavirus 2019, compare predictive ability score, Sequential Organ Failure Assessment Confusion, Urea, Respiratory rate, Blood pressure, Age 65 (CURB65) score. Design: Retrospective observational cohort. Setting: Tongji Hospital Wuhan, Subjects:...
A COVID-19 outbreak started in Wuhan, China, last December and now has become a global pandemic. The clinical information caring of critically ill patients with needs to be shared timely, especially under the situations that there is still largely ongoing spread many countries.A multicenter prospective observational study investigated all received 19 ICUs 16 hospitals over 24 h between 8 AM February 2h 27, 2020. demographic information, characteristics, vital signs, complications, laboratory...
Abstract The circular RNA ciRS-7 has been reported to be involved in the pathogenesis of various tumors, including gastric and colorectal cancer. However, role esophageal squamous cell carcinoma (ESCC) remains unsolved. In this study, we found that expression was significantly upregulated ESCC cancer tissues compared with matched normal associated poor patient survival. Overexpression abrogated tumor-suppressive roles miR-7 proliferation, migration invasion vitro as well tumor growth lung...
Abstract The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) started in the end China has triggered a global public health crisis. Previous studies have shown that SARS-CoV-2 infects cells binding angiotensin-converting enzyme (ACE2), which is same as SARS-CoV. expression and distribution ACE2 pancreas are unknown. At time, injury after infection not been concerned. Here, we collected datasets (bulk RNA-seq single-cell...
The mortality risk of coronavirus disease 2019 (COVID-19) patients has been linked to the cytokine storm caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Understanding inflammatory responses shared between COVID-19 and other infectious diseases that feature storms may therefore help in developing improved therapeutic strategies. Here, we use integrative analysis single-cell transcriptomes characterize signatures peripheral blood mononuclear cells from with COVID-19, sepsis, HIV...
Background: The outbreak of coronavirus disease 2019 (COVID-19) has led to a large and increasing number patients requiring prolonged mechanical ventilation tracheostomy. indication optimal timing tracheostomy in COVID-19 are still unclear, the outcomes about have not been extensively reported. We aimed describe clinical characteristics with confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) pneumonia who underwent elective tracheostomies. Methods: multi-center, retrospective,...
The long non-coding RNA (lncRNA) NKILA (nuclear transcription factor NF-κB interacting lncRNA) functions as a suppressor in human breast cancer and tongue cancer. However, the clinical significance biological roles of esophageal squamous cell carcinoma (ESCC) remain unknown. In this study, we showed that was downregulated ESCC tissues cells compared with their normal counterparts. Low expression correlated large tumor size advanced TNM stage, predicted poor overall disease-free survival...
Background: The data on long-term outcomes of patients infected by SARS-CoV-2 and treated with extracorporeal membrane oxygenation (ECMO) in China are merely available. Methods: A retrospective study included 73 ECMO 21 intensive care units Hubei, China. Data demographic information, clinical features, laboratory tests, durations, complications, living status were collected. Results: ECMO-treated had a median age 62 (range 33–78) years 42 (63.6%) males. Before initiation, severe respiratory...
Abstract Impaired antigen presentation either in dendritic cells (DCs) or tumor impedes the triggering of antitumor immunity cell killing, resulting failures multiple types cancer immunotherapy. Herein, strategy using dual‐targeting nanomedicines to simultaneously improve antigens by both DCs and is proposed. It shown that tuning surface charge nanoparticles (NPs) incorporating different amounts cationic lipids alters vivo NP tissue accumulation cellular targeting profiles. NPs with...
Abstract Understanding tumor heterogeneity and immune infiltrates within the tumor-immune microenvironment (TIME) is essential for innovation of immunotherapies. Here, combining single-cell transcriptomics chromatin accessibility sequencing, we profile intratumor malignant cells properties TIME in primary central nervous system diffuse large B-cell lymphoma (PCNS DLBCL) patients. We demonstrate diverse programs related to tumor-promoting pathways, cell cycle response. By integrating data...
SARS-CoV-2 infection activates coagulation and stimulates innate immune system. Little is known about coagulopathy response of inflammation in ICU patients with COVID-19. Derangement markers induced by infection, as well their correlations were elucidated.One hundred eight COVID-19 (28 survivors 80 non-survivors) Tongji hospital Wuhan Jinyintan hospital, Wuhan, China included. Coagulation parameters, infectious inflammatory dynamically analysed. The correlation between was...
Metabolic reprogramming is often observed in sepsis-associated microglial cells. However, little known about the aberrant metabolic genes involved neuroinflammation and lipid accumulation cells of encephalopathy (SAE). Here, we show that hexokinase 2 (HK2) upregulated strongly associated with inflammatory response metabolism lipopolysaccharide-induced BV2 Downregulation HK2 lowered activation NOD-like receptor signaling family pyrin domain containing 3, both hippocampus cecal ligation...
Sepsis-associated encephalopathy is a common neurological complication of sepsis. Despite advances in pathological and diagnostic investigations, its treatment remains major challenge. In sepsis-associated encephalopathy, neuroinflammatory overactivation mitochondrial damage are thought to contribute cognitive behavioral impairments. this study, we found that administration (−)-Epicatechin, dietary flavonoid the flavan-3-ol subgroup, improves memory deficits behavior performance by...
We aimed at probing impact of LINC00858 on esophageal squamous cell carcinoma (ESCC) progression via ZNF184-FTO-m6A-MYC axis.Expression related genes (LINC00858, ZNF184, FTO, and MYC) was detected in ESCC tissues or cells their relationships were assessed. After expression alterations cells, proliferation, invasion, migration, apoptosis detected. Tumor formation nude mice conducted.LINC00858, MYC overexpressed cells. enhanced ZNF184 to upregulate which augmented expression. knockdown...
Abstract Objectives The seed of Phaseolus calcaratus Roxburgh (PHCR) has traditionally been used as a herbal medicine, considered to have anti-inflammatory potential. Here we examined the ability PHCR extract inhibit inflammatory responses macrophages bacterial toxin and mechanism involved. Methods In present study, prepared four fractions from an ethanol investigated their effects on production nitric oxide cytokines, expression inducible synthase (iNOS) in lipopolysaccharide...
Background: Most evidence regarding the risk factors for early in-hospital mortality in patients with severe COVID-19 focused on laboratory data at time of hospital admission without adequate adjustment confounding variables. A multicenter, age-matched, case-control study was therefore designed to explore dynamic changes parameters during first 10 days after and identify indicators this patient cohort.Methods: Demographics clinical were extracted from medical records 93 pairs who had been...
Sepsis-associated thrombocytopenia (SAT) is common in critical patients and results the elevation of mortality. Red cell distribution width (RDW) can reflect body response to inflammation oxidative stress. We try investigate relationship between RDW prognosis with SAT through machine learning.809 were retrospectively analyzed from Medical Information Mart for Intensive Care III (MIMIC-III) database. The eXtreme Gradient Boosting (XGBoost) SHapley Additive exPlanations (SHAP) used analyze...
Abstract The aim of our study was to describe the clinical characteristics and outcomes patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia who underwent elective tracheostomies. We investigated all COVID-19 tracheostomies in intensive care units (ICUs) 23 hospitals Hubei Province, China, from January 8, 2020 March 25, 2020. Demographic information, characteristics, treatment, details tracheostomy procedure, successful weaning after tracheostomy,...