A5028966818- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Salmonella and Campylobacter epidemiology
- Bacteriophages and microbial interactions
- Gut microbiota and health
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Microbial infections and disease research
- Probiotics and Fermented Foods
- Antimicrobial Resistance in Staphylococcus
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Escherichia coli research studies
- Genomics and Phylogenetic Studies
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
- Antibiotics Pharmacokinetics and Efficacy
- Clostridium difficile and Clostridium perfringens research
- Veterinary medicine and infectious diseases
- Vibrio bacteria research studies
- Animal Nutrition and Physiology
- Listeria monocytogenes in Food Safety
- Bacterial Identification and Susceptibility Testing
- Aquaculture disease management and microbiota
- Inorganic and Organometallic Chemistry
Sichuan University
2016-2025
Sichuan Center for Disease Control and Prevention
2009-2024
Washington State University
2017-2019
Ministry of Education of the People's Republic of China
2015-2017
The Ohio State University
2017
Sichuan Agricultural University
2015
Shaanxi Normal University
2001
To identify a novel plasmid-mediated colistin resistance gene in Klebsiella pneumoniae isolated from chickens China. WGS was used to gene. The transferability of plasmids carrying mcr-7.1 investigated by conjugation experiments. expression the examined using an vector. A mcr-7.1, sharing 70% amino acid identity with mcr-3 gene, identified three K. strains found IncI2-type plasmid (pSC20141012) that co-harboured blaCTX-M-55 one isolate. pSC20141012 can be transferred SC20141012 Escherichia...
Abstract Background Chronic diarrhea is a common disease causing morbidity and mortality of captive rhesus macaques (RMs, Macaca mulatta ). in RMs typically characterized by long-term weak response to antibiotic treatment. Diarrhea also humans can cause death. However, the etiology about half diarrheal cases still unclear. Therefore, we performed shotgun metagenomic sequencing characterize differences gut microbiome resistome chronic asymptomatic individuals. Results Our results showed...
The mcr-1 gene was detected in 5.11% (58/1136) of Escherichia coli isolates chicken origin from 13 provinces China. A novel variant, named mcr-1.3, encoding an Ile-to-Val functional variant MCR-1 identified a sequence type 155 (ST155) strain. An mcr-1.3-containing IncI2 plasmid, pHeN867 (60,757 bp), identified. transfer led to 32-fold increase the MIC colistin recipient, exhibiting effect on resistance that similar mcr-1.
Abstract Tibetan Chickens should have unique gastrointestinal microbiota because of their particular habitats. Thus, the aim this study was to investigate cecal from five typical high‐altitude regions China. Lohmann egg‐laying hens ( LM s) and Daheng broiler chickens DH were chosen as controls. The bacterial populations surveyed by high‐throughput sequencing HTS ) 16S rRNA hypervariable region V3‐V4 (16S rRNAV 3‐V4) combined with community‐fingerprinting analysis gene based on polymerase...
To obtain full details of gut microbiota, including bacteria, fungi, bacteriophages, and helminths, in giant pandas, we created a comprehensive microbial genome database used metagenomic sequences to align against the database. We delineated detailed different microbiota structures GPs. A total 680 species 198 185 45 helminths were found. Compared with 16S rRNA sequencing, dominant bacterium phyla not only included Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria but also...
Anthropogenic activities near urban rivers may have significantly increased the acquisition and dissemination of antibiotic resistance. In this study, we investigated prevalence colistin resistant strains in Funan River Chengdu, China. A total 18 mcr-1-positive isolates (17 Escherichia coli 1 Enterobacter cloacae) 6 mcr-3-positive (2 Aeromonas veronii 4 hydrophila) were detected, while mcr-2, mcr-4 mcr-5 genes not detected any isolates. To further explore overall resistance River, water...
ABSTRACT SXT/R391 integrative and conjugative elements (ICEs) were detected in 8 out of 125 Proteus mirabilis isolates from food-producing animals China. Whole-genome sequencing revealed that seven ICEs identical to ICE Pmi Jpn1, carrying the cephalosporinase gene bla CMY-2 . Another one, designated Chn1, carried five resistance genes. All eight could be transferred Escherichia coli via conjugation. The results highlight idea animal farms are important reservoir ICE-containing P.
Salmonella is one of the most important zoonotic pathogens that can cause both acute and chronic illnesses in poultry flocks, also be transmitted to humans from infected poultry. The purpose this study was investigate prevalence, antimicrobial resistance, molecular characteristics isolated diseased clinically healthy chickens Anhui, China. In total, 108 isolates (5.66%) were successfully recovered chicken samples (n = 1908), including pathological tissue (57/408, 13.97%) cloacal swabs...
The aim of the present study was to investigate antibiotic resistance profiles and molecular epidemiology extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates from two production swine operations in Sichuan Province, China, between August 2002 February 2007. prevalence ESBL-producing E. increased dramatically 2.2% 10.7% during this period. This increase appeared mostly related dissemination CTX-M–type ESBLs among isolates. Of 212 studied, 14 harbored ESBL genes. Among...
To demonstrate the resistance of antibiotics and disinfectants to Escherichia coli isolates, 255 E. strains were isolated from 328 retail meat samples in this study. Susceptibility testing results showed that 85.5% isolates resistant at least one antibiotic drug. The highest sulfamethoxazole (61.6%), followed by tetracycline (61.2%), ampicillin (48.2%), cefalotin (29.8%), kanamycin (22.4%). minimum inhibitory concentrations cetyltrimethylammonium bromide, N,N-didecyl-N,N-dimethylammonium...
Indole derivatives 3-amino-6-carboxyl-indole and 3-nitro-6-amino-indole were designed synthesized based on the TolC structure. They proved to have potent synergistic antibacterial effects chloramphenicol, tetracycline, erythromycin, ciprofloxacin against Escherichia coli YD2 FJ307 with decreased minimal inhibitory concentrations (MICs) at 2-64 folds. To research its functional site, BL21(DE3)-3 expressing a target-site mutated was constructed by red homologous recombination site-directed...
Pullorum disease caused by Salmonella pullorum is one of the most important infectious diseases in poultry industry, responsible for causing substantial economic losses globally. On farms, traditional method to detect S. infection mainly involves collection feces and sera test antigens antibodies, respectively, but regularity dissemination internal organs shedding patterns antibody production infected chickens remains unclear. Herein we aimed investigate different bacterial faeces as well...