A5100369881- Osteomyelitis and Bone Disorders Research
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
- Inflammasome and immune disorders
- Infectious Diseases and Tuberculosis
- Oral Health Pathology and Treatment
- Bone health and treatments
- Orthopedic Infections and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Dermatological and COVID-19 studies
- Pelvic floor disorders treatments
- Heterotopic Ossification and Related Conditions
- Cell Adhesion Molecules Research
- Endometrial and Cervical Cancer Treatments
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Autoimmune and Inflammatory Disorders Research
- Autoimmune Bullous Skin Diseases
- Inflammatory Myopathies and Dermatomyositis
- Dermatological and Skeletal Disorders
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Beijing University of Chinese Medicine
2020-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2017-2025
Jackson and Tull (United States)
2025
Tianjin University of Traditional Chinese Medicine
2025
China-Japan Friendship Hospital
2024-2025
Peking University International Hospital
2024-2025
Peking University
2024-2025
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2021-2025
The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome.We recruited all patients presenting Peking Union Medical College Hospital from 2004 2015 diagnosed with syndrome. medical data, test results imaging were collected for patients.One hundred sixty-four (111 women 53 men) our cohort. mean age 40.71 years. Nine had osteoarticular symptoms without skin involvement. One forty-three 25 palmoplantar pustulosis severe acne, respectively. Psoriasis vulgaris...
SAPHO syndrome is a highly heterogeneous disease with distinct treatment response. We report the largest cohort of and explore its clinical classification special interest in spinal sacroiliac involvement.A total 354 patients were recruited Peking Union Medical College Hospital. The demographic, imaging data collected at baseline. Spinal involvement was determined by co-existence related symptoms evidence lesions spine or joints on either bone scintigraphy, CT MRI.A 197 (55.6%) identified to...
The objective of this study was to investigate the spatiotemporal delivery nanomedicines by an injectable, thermosensitive, and nanoparticle-self-aggregated hydrogel for peritumoral chemotherapy. Doxorubicin (Dox) taken as model medicine, which encapsulated into poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT) nanoparticles (PECT/Dox NPs). Macroscale formed thermosensitive self-aggregation...
<h3>Importance</h3> Nail involvement is common in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, which has a strong association with quality of life patients SAPHO. Tofacitinib an oral Janus kinase inhibitor that been previously shown to be effective for nail psoriasis. <h3>Objective</h3> To assess the efficacy safety tofacitinib treatment SAPHO syndrome. <h3>Interventions</h3> Participants received tofacitinib, 5 mg, twice daily, 12 weeks. <h3>Design, Setting,...
Great progress has been made in the field of vascular tissue engineering, with some artificial grafts already exhibiting promising outcomes animal models. However, these studies were mostly conducted using healthy animals, which are not representative actual clinical demands. Indeed, patients who require graft implantation often accompanied by other comorbidities, such as hyperlipidaemia, hypertension and diabetes should also be taken into consideration when assessing potential that intended...
Objective: To measure the expression of proinflammatory, anti-inflammatory cytokines, and receptor activator NK-κB ligand (RANKL)/osteoprotegerin (OPG) in synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, to assess relationship between those factors disease activity. Methods: We studied 30 cases SAPHO syndrome 15 healthy controls. According Visual Analogue Scale (VAS) pain scores Bath Ankylosing Spondylitis Activity Index (BASDAI), patients were divided into active group...
To explore the patterns of osteoarticular involvement in SAPHO syndrome. Baseline clinical characteristics and imaging data 99mTc-MDP whole-body bone scintigraphy (WBBS) were collected from 157 out 164 patients diagnosed with The twelve most frequently involved sites analysed by hierarchical cluster analysis Ward minimum-variance method. Three distinctive identified: spinal type (70 patients, 44.6%), predominantly thoracic, lumbar or sacral vertebral lesions; costal (52 33.1%), lesions...
Postherpetic neuralgia (PHN) is a type of refractory neuropathic pain that causes significant suffering, disability, economic loss, and medical burden. In this study, we aim to evaluate the efficacy safety interferon (IFN)-α1b injection into intervertebral foramen patients with PHN. This study protocol for randomized, double-blind placebo-controlled multicenter clinical trial. A total 200 participants PHN from 11 hospitals will be recruited randomly assigned treatment group administered...
BACKGROUND Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, a rare inflammatory disease, was described in 1987 by Chamot et al , who identified its common characteristics transitional forms through case reports. The incidence rate is now 1 10000 among Caucasians 0.00144 Japanese. Pneumothorax occurs when gas enters the pleural cavity, typically due to lung disease or chest trauma, characterized as either spontaneous traumatic. Spontaneous pneumothorax commonly linked...
Journal Article Accepted manuscript The Silent Stone Armor Beneath the Golden Bell: A Severe Case of Calcinosis Cutis in Dermatomyositis Get access Chen Li, Li Department Rheumatology and Immunology, Peking University International Hospital, Beijing, ChinaDepartment Rheumatology, Fangshan Beijing Chinese Medicine, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Shao-hui Geng, Geng School Life Sciences, Shu-han Yang, Yang Materia Medica, Hong-xu Liu, Liu...
Palmoplantar pustulosis is a chronic recurrent dermatological condition of unknown aetiology, and available clinical experience suggests that symptoms tend to diminish during pregnancy, but we report case 31-year-old woman whose worsened after which prompted us focus on this problem cure her disease with new treatment regimen, tofacitibi.
In our manuscript, we present a case study of siblings with Generalized Pustular Psoriasis (GPP) and Acrodermatitis Continua Hallopeau (ACH), both harboring IL36RN gene mutations. The 3-year-old proband exhibited systemic pustules leading to GPP diagnosis, while his 6-year-old sister developed nail ulcers subungual characteristic ACH. Despite standard treatments, their conditions were refractory. Genetic analysis revealed homozygous splice variant c.115+6 T>C, heterozygous parents. This...
ABSTRACT Ischemia‐reperfusion (IR)‐induced myocardial damage represents a major pathological event in coronary artery disease (CAD). Effective therapeutic strategies are urgently needed to improve clinical outcomes for CAD patients. Apelin‐13, primarily produced by magnocellular neurons, exhibits diverse biological functions across various cell types and tissues. However, its role IR injury remains unexplored. In this study, we utilized an vitro model of using H9c2 cardiomyocytes investigate...