A5011463228- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cardiac Imaging and Diagnostics
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Cell Adhesion Molecules Research
- Cardiac Structural Anomalies and Repair
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Osteomyelitis and Bone Disorders Research
- Cardiovascular Function and Risk Factors
- CNS Lymphoma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Advanced X-ray and CT Imaging
- Neuroendocrine Tumor Research Advances
- Vascular Tumors and Angiosarcomas
- Bone health and treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Peking Union Medical College Hospital
2016-2025
Tongren Hospital
2020
Wuhan University
2020
Adenosine-Stress Dynamic Myocardial Perfusion Imaging With Second-Generation Dual-Source CT: Comparison Conventional Catheter Coronary Angiography and SPECT Nuclear ImagingYining Wang1, Ling Qin2, Ximin Shi3, Yong Zeng2, Hongli Jing3, U. Joseph Schoepf4 Zhengyu Jin1Audio Available | Share
Background Molecular imaging targeting angiogenesis can specifically monitor the early therapeutic effect of antiangiogenesis therapy. We explore predictive values an integrin αvβ3-targeted tracer, 99m Tc-PEG 4 -E[PEG -c(RGDfK)] 2 ( Tc-3PRGD ), for monitoring efficacy Endostar antiangiogenic therapy and chemotherapy in animal models. Methods The pancreatic cancer xenograft mice were randomly divided into four groups, with seven animals each group treated different groups 10 mg/kg/day...
Purpose To evaluate an integrin imaging approach based on single photon emission computed tomography (SPECT)/computed (CT) by using technetium 99m (99mTc)-dimeric cyclic arginine-glycine-aspartic acid (RGD) peptides with three polyethylene glycol spacers (3PRGD2) as the tracer to target αvβ3 expression in lung cancer and lymph node metastasis. Materials Methods With ethics committee approval written informed consent, 65 patients (41 male, 24 female; mean age, 60 years ± 11 [standard...
Increased expression of fibroblast activating protein (FAP) in fibrous caps may contribute to progression atherosclerotic plaques. <b>Methods:</b> Forty-one patients who underwent gallium-68-conjugated quinoline-based FAP inhibitor (<sup>68</sup>Ga-FAPI-04) PET/CT for non-cardiovascular indications were retrospectively analyzed. Correlations assessed between the uptake <sup>68</sup>Ga-FAPI-04 large arterial walls (SUV<sub>max</sub> and target-to-background ratio, TBR) degree calcification...
To explore the patterns of osteoarticular involvement in SAPHO syndrome. Baseline clinical characteristics and imaging data 99mTc-MDP whole-body bone scintigraphy (WBBS) were collected from 157 out 164 patients diagnosed with The twelve most frequently involved sites analysed by hierarchical cluster analysis Ward minimum-variance method. Three distinctive identified: spinal type (70 patients, 44.6%), predominantly thoracic, lumbar or sacral vertebral lesions; costal (52 33.1%), lesions...
Whole-body bone scintigraphy (WBBS) and MRI are widely used in assessment of patients with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. However, the value F-18 fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) SAPHO syndrome was unclear. The aim this study to characterize manifestation on 18F-FDG PET/CT explore its relationship clinical symptoms WBBS.Twenty-six who suffered from had undergone whole-body were recruited Peking Union...
Abstract Background The study aimed to establish a 68 Ga-FAPI-04 kinetic model in hepatic lesions, determine the potential role of parameters differentiation hepatocellular carcinoma (HCC) from non-HCC lesions. Material and methods Time activity curves (TACs) were extracted seven HCC lesions five obtained dynamic positron emission tomography (PET) scans eight patients. Three models applied TACs, using image-derived artery and/or portal vein as input functions. maximum standardized uptake...
Three patients with known lung cancer came on different days to our department have a bone scan evaluate possible osseous metastatic disease. The images showed increased Tc-99m methylene diphosphonate (Tc-99m MDP) activity in the liver and lesser degree spleen, whereas from other same no abnormal or spleen. On day, shortly before scan, all 3 had magnetic resonance imaging an intravenous injection of Magnevist (Gadolinium-DTPA), which was not previously cause altered MDP distribution. In...
Chronic alcohol consumption initially leads to asymptomatic left ventricular dysfunction, but can result in myocardial impairment and heart failure if ongoing. This study sought characterize tissues oxidative metabolism subjects with chronic by quantitative cardiovascular magnetic resonance (CMR) 11C-acetate positron emission tomography (PET)/computed (CT). Thirty-four male (48.8 ± 9.1 years) > 28 g/day for 10 years 35 age-matched healthy (49.5 9.7 underwent CMR PET/CT. Native post T1 values...
Tumor-induced osteomalacia (TIO) is rare paraneoplastic disorder generally caused by small benign neoplasm. Somatostatin receptor imaging has emerged as of the choice in localization causative tumors new patients with clinical diagnosis TIO. An accurate tumor using somatostatin followed successful surgical removal offers cure disease. In percentage patients, however, there can be recurrent disease after surgery. this retrospective investigation, we tried to assess whether Tc-HYNIC-TOC...
Background Glomerular filtration rate (GFR) is essential for renal function evaluation and classification of chronic kidney disease (CKD), while the reference method in children are cumbersome. In Chinese children, there was no data about GFR measured through plasma or clearance exogenous markers, therefore validated GFR-estimating tools this population. Methods We with double-sample 99mTc-DTPA (mGFR) 87 hospitalized injury. Using mGFR as golden standard, we evaluate efficiency four...
This retrospective analysis examined the difference in pre- and postchemotherapy levels of vascular endothelial growth factor (VEGF) as an indicator osteosarcoma prognosis. VEGF protein were assessed immunohistochemically primary tumour samples from 61 patients diagnosed between February 2001 July 2005. The reduction was categorized into weak (23 patients) strong (38 patients). 5-year survival rate significantly lower group (34.8%) than (73.7%). had higher rates metastasis recurrence....
<title>Abstract</title> Intravascular large B-cell lymphoma (IVLBCL) is relatively rare. Due to the lack of distinctive symptoms, diagnosis difficult. Fever unknown origin (FUO) most common symptom. This study retrospectively analyzed IVLBCL patients and FUO between February 2015 October 2023. Diagnostic predictive models were constructed using multivariable logistic regression in training cohort including 42 45 patients. Model 1 consisted peripheral edema, hypoxemia, neurological...
A 63-year-old woman had persistent bloody pericardial effusion. Tuberculous pericarditis was initially suspected, but empirical antituberculosis therapy futile. FDG PET/CT study revealed abnormal activity in multiple parts of the pericardium, especially along with aorta and main pulmonary artery, left atrium. However, there no other body. Histopathologic examination primary angiosarcoma.
To evaluate the accuracy of plasma clearance iohexol (PCio) for glomerular filtration rate (GFR) measurement in Chinese children with chronic kidney disease (CKD) and assess feasibility single-blood-sample method or dried capillary blood spots determining PCio.Totally 45 CKD were included,in whom (99m) Technetium-diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) simultaneously determined. Blood samples obtained 2,4,and 5 hours after injection. In addition, we also evaluated efficacy single...
Objective . Kinetic modeling of dynamic 11 C-acetate PET imaging provides quantitative information for myocardium assessment. The quality and quantitation images are known to be dependent on reconstruction methods. This study aims investigate the impacts algorithms analysis cardiac imaging. Methods Suspected alcoholic cardiomyopathy patients (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">24</mml:mn></mml:math>)...