A5090202478- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neurogenesis and neuroplasticity mechanisms
- Adrenal Hormones and Disorders
- Neuroendocrine Tumor Research Advances
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Neurosurgical Procedures and Complications
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Neurological disorders and treatments
- TGF-β signaling in diseases
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Bone Tumor Diagnosis and Treatments
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Chinese University of Hong Kong, Shenzhen
2022-2025
University of Chinese Academy of Sciences
2025
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
University of Pennsylvania Health System
2024-2025
Chinese University of Hong Kong
2025
Sixth Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Chronic subdural hematoma (CSDH) is a trauma-associated condition commonly found in elderly patients. Surgery currently the treatment of choice, but it carries significant risk recurrence and death. Nonsurgical treatments remain limited ineffective. Our recent studies suggest that atorvastatin reduces hematomas improves clinical outcomes patients with CSDH.To investigate safety therapeutic efficacy to nonsurgically treat CSDH.The Effect Atorvastatin on Subdural Hematoma (ATOCH) randomized,...
The brain is the central control hub of whole body. Hence, consequences diseases can be lethal. Despite progress in fundamental and clinical research, several key obstacles remain to addressed. As an emerging science, aggregation-induced emission (AIE) has attracted great interest past few years owing overwhelming advantages AIE luminogens (AIEgens), including their wavelength, quantum yield, spatial resolution, photosensitivity, photostability, signal-to-noise ratio, biocompatibility....
Background Intranasal transplantation of ANGE-S003 human neural stem cells showed therapeutic effects and were safe in preclinical models Parkinson’s disease (PD). We investigated the safety tolerability this treatment patients with PD whether these would be apparent a clinical trial. Methods This was 12-month, single-centre, open-label, dose-escalation phase 1 study 18 advanced assigned to four-time intranasal 3 doses: 1.5 million, 5 million or 15 evaluate their efficacy. Results 7...
Intracerebral hemorrhage (ICH) remains a life-threatening condition due to its high mortality and limited treatment options. This study explores novel therapeutic strategy using engineered exosomes derived from endothelial progenitor cells (EPC-EXOs) improve ICH outcomes. EPC-EXOs were modified with CD47-enriched red blood cell membrane via co-extrusion enhance their anti-phagocytic properties, thereby reducing degradation by activated microglia after ICH. A minimally invasive...
Pituitary abscess is a rare disorder with nonspecific presenting manifestations, often making correct preoperative diagnosis difficult. To better determine the salient signs and symptoms of pituitary to evaluate effectiveness surgical antibiotic therapies, we conducted review patients treated for at Peking Union Medical College Hospital (PUMCH).A total 33 consecutive referred PUMCH between 1991 2007 were included. While 30 underwent surgery therapy, three accepted only therapy. A complete...
Object The standard transsphenoidal approach has been successfully used to resect most pituitary adenomas. However, as a result of the limited exposure provided by this procedure, complete surgical removal adenomas with parasellar or retrosellar extension remains problematic. By additional bone cranial base, extended provides better and clival region compared approach. authors describe their experience remove invading anterior cavernous sinus (CS), clivus. Methods Retrospective analysis was...
Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations changes dysfunction are less detailed. Here, we examined brains APP/presenilin 1 (PS1) transgenic (Tg) mice aged 2, 3.5, 5 8 months using 18F-labed fluorodeoxyglucose (18F-FDG) microPET to assess age- region-specific metabolism. FDG uptake was calculated as relative standardized value (SUVr). Morris water maze (MWM) used...
<b><i>Background:</i></b> There are no reliable predictive models for recurrence after transsphenoidal surgery (TSS) Cushing’s disease (CD). <b><i>Objectives:</i></b> This study aimed to develop machine learning (ML)-based CD initial TSS and evaluate their performance. <b><i>Method:</i></b> A total of 354 patients were included in this retrospective, supervised learning, data mining study. Predictive developed according...
Intracerebral hemorrhage (ICH) is a severe stroke subtype with limited therapeutic options.Programmed cell death (PCD) crucial for immunological balance, and includes necroptosis, pyroptosis, apoptosis, ferroptosis, necrosis.However, the distinctions between these programmed modalities after ICH remain to be further investigated.We used single-cell transcriptome (single-cell RNA sequencing) spatial (spatial techniques investigate PCD-related gene expression trends in rat brain following...
Our objective was to achieve the enhanced delivery of vascular endothelial growth factor (VEGF) ischemically disordered brain through transferrin-coupled liposomes (Tf-PLs) via intravenous administration, and observe effect Tf-VEGF-PLs on ischemic neuroprotection angiogenesis. Cerebral VEGF overexpression achieved with Tf-PLs by injection 48 hr after an acute stroke. β-Galactosidase expression monitored; saline injected as a control. The success postischemic gene transduction confirmed...
Depletion of calcium (Ca2+) from the endoplasmic reticulum (ER) activates ubiquitous store-operated Ca2+ entry (SOCE) pathway which sustains long-term signals and is critical for cellular functions. Stromal interacting molecule 1 (STIM1) serves a dual role as an ER sensor activator SOCE. Aberrant expression STIM1 could be observed in several human cancer cells. However, regulating tumorigenesis glioblastoma still remains unclear.Expression protein panel cell lines (U251, U87 U373) different...
Primary lymphocytic hypophysitis (LYH) is rare, and it often evaluated in a small case series. This study aimed to describe the diagnosis treatment of primary LYH larger cohort.A retrospective was conducted at Peking Union Medical College Hospital from 1999 2016.Fifty patients (28 histologically diagnosed 22 clinically-diagnosed) were eligible for inclusion.Clinical, endocrine, pathological imaging findings; therapies outcomes assessed. Ordinal logistic regression analysis used evaluate...
Purpose: Ischemic vascular diseases, including myocardial infarction (MI) and stroke, have been found to be associated with elevated expression of αvβ3-integrin, which provides a promising target for semi-quantitative monitoring the disease.For first time, we employed 68 Ga-S-2-(isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid-PEG3-E[c(RGDyK)]2 ( Ga-PRGD2) evaluate αvβ3-integrin-related repair in post-MI post-stroke patients via positron emission tomography/computed...
Abstract Invasive pituitary adenomas (PAs) are often refractory to standard therapy and salvage treatment with temozolomide (TMZ). Hyperactivation of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) pathway contributes chemotherapy resistance in many cancers. XL765, a novel dual-PI3K/mTOR inhibitor, has recently shown its efficacy as monotherapy combination conventional therapeutics The hyperactive PI3K/AKT/mTOR frequently occurs invasive PAs. In this study, we...
Pituitary somatotroph adenomas result in dysregulated growth hormone (GH) hypersecretion and acromegaly; however, regulatory mechanisms that promote GH remain elusive. Here, we provide evidence STAT3 directly induces tumor cell GH. Evaluation of pituitary tumors revealed expression was enhanced human GH-secreting compared with nonsecreting tumors. Moreover, were concordant a adenoma tissue array. Promoter analysis rat line (GH3) specifically binds the Gh promoter transcription. Stable GH3...