A5033602643- Aquaculture disease management and microbiota
- Molecular Biology Techniques and Applications
- Alzheimer's disease research and treatments
- Identification and Quantification in Food
- Gut microbiota and health
- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Fermentation and Sensory Analysis
- MicroRNA in disease regulation
- Reproductive biology and impacts on aquatic species
- Tea Polyphenols and Effects
- Aquaculture Nutrition and Growth
- Food Quality and Safety Studies
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Animal Virus Infections Studies
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Physiological and biochemical adaptations
- Neuroscience and Neuropharmacology Research
- Invertebrate Immune Response Mechanisms
- Liver Disease Diagnosis and Treatment
Nanjing Normal University
2019-2025
Zhejiang University of Technology
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Beijing Academy of Agricultural and Forestry Sciences
2022-2024
Academy of Medical Sciences
2011-2024
Beijing Technology and Business University
2018-2023
Shandong Freshwater Fisheries Research Institute
2018-2023
Institute of Laboratory Animal Science
2013-2022
Chinese Academy of Fishery Sciences
2022
The Ohio State University Wexner Medical Center
2020-2022
ABSTRACT The shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. source high loads saliva, however, remains elusive. Here we investigate the early target cells infection entire array tissues Chinese macaques after intranasal inoculations with single-cycle pseudotyped virus and pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2 + ) were widely distributed upper tract, ACE2...
The topic of gut microbiota is currently attracting considerable interest as a potential factor in Alzheimer's disease (AD). However, the extent and time course alterations microbiota, their effects on AD pathology remain uncertain. Herein, we compared fecal microbiomes short chain fatty acid composition (SCFAs) between wild-type model mice at different ages under strictly controlled specific pathogen free conditions, also conducted microscopic investigations intestinal structures. Our...
Severe acute respiratory syndrome (SARS) is caused by a coronavirus (SARS-CoV) and has the potential to threaten global public health socioeconomic stability. Evidence of antibody-dependent enhancement (ADE) SARS-CoV infection in vitro non-human primates clouds prospects for safe vaccine. Using antibodies from SARS patients, we identified characterized B-cell peptide epitopes with disparate functions. In rhesus macaques, spike glycoprotein peptides S471-503, S604-625, S1164-1191 elicited...
Sauce-flavor Baijiu is representative of solid-state fermented Baijiu. It significant to deeply reveal the dynamic changes microorganisms in manufacturing process and their impact on formation flavor chemicals correlated with quality can be divided into seven rounds, from which kinds base Baijius are produced. The third round significantly better than that first second but mystery behind phenomenon has not yet been revealed. Based high-throughput sequencing analysis grains, correlation...
Histone deacetylase 6 (HDAC6) is currently being discussed as a promising therapeutic target for the treatment of Alzheimer's disease (AD). Mounting evidence indicates that increased HDAC6 expression may contribute to AD-associated neurodegeneration, although beneficial effects have also been identified. In present study, we tested potential two selective inhibitors, tubastatin A and ACY-1215, rescue cognitive deficits in mouse model AD. We found both ACY-1215 alleviated behavioral deficits,...
In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 cases of MERS-CoV have been reported, 54 fatalities. Animal models for infection humans are needed to elucidate MERS pathogenesis and develop vaccines antivirals. this study, we developed rhesus macaques model using intratracheal inoculation. The infected monkeys...
The outbreak of human infections caused by novel avian-origin influenza A(H7N9) in China since March 2013 underscores the need to better understand pathogenicity and transmissibility these viruses mammals. In a ferret model, was found be less than that an A(H5N1) strain but comparable 2009 pandemic A(H1N1), based on clinical signs, mortality, virus dissemination, results histopathologic analyses. Influenza could replicate upper lower respiratory tract, heart, liver, olfactory bulb. It is...
Abstract Gut microbiota, comprising a vast number of microorganism species with complex metagenome, are known to be associated Alzheimer's disease (AD) and amyloid deposition. However, studies related gut microbiota have been mostly restricted comparisons deposits, while investigations on neurobehavioral changes the pathogenesis AD limited. Therefore, we aimed identify relationship between in intestinal microbiome AD. APP swe /PS1 ΔE9 (PAP) transgenic mice wild‐type (WT) different age groups...
Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations changes dysfunction are less detailed. Here, we examined brains APP/presenilin 1 (PS1) transgenic (Tg) mice aged 2, 3.5, 5 8 months using 18F-labed fluorodeoxyglucose (18F-FDG) microPET to assess age- region-specific metabolism. FDG uptake was calculated as relative standardized value (SUVr). Morris water maze (MWM) used...
Abstract Background Tropical stenothermal fish exhibit special tolerance and response to cold stress. However current knowledge of the molecular mechanisms stress in aquatic ectotherms is largely drawn from eurythermal or extreme species. The tiger barb Puntius tetrazona a tropical fish, with great popularity aquarium trade research. Results To investigate mechanism P. low temperature, were exposed increasing levels acute Histopathological analysis showed that brain, gill, liver muscle...
A common symptom in Alzheimer's disease (AD) is cognitive decline, of which the potential pathogenesis remains unclear. In order to understand mechanism gut microbiota AD, it necessary clarify relationship between and metabolites. Behavioral tests, pathological examination, metagenomics, metabolomics were applied analyze difference metabolome APPswe/PS1ΔE9 (PAP) mice with decline age-matched controls, their possible correlations. Our results showed that PAP health had different structures...
The compositions of the microbial community in fermented grains Sauce-flavor baijiu produced different regions have diverse characteristics; however, reasons for this remain unclear. present study investigated contributions environmental microorganisms to as well volatile compounds Beijing region using high-throughput sequencing combined with sourcetracker analysis, and compared differences microorganism their roles production process from regions.The results showed that tools were main...
Nicotine has a therapeutic benefit in treating Alzheimer's disease (AD). In the present study we show that nicotine decreases accumulation of beta-amyloid (Abeta) cortex and hippocampus APP (V717I) transgenic mice. prevents activation NF-kappaB c-Myc by inhibiting MAP kinases (MAPKs). As result, activity inducible NOS production NO are down-regulated. RNA interference experiments above nicotine-mediated process requires alpha7 nAChR. Abeta via alpha7nAChRs through MAPK, NF-kappaB, c-myc...
Abstract A new SARS animal model was established by inoculating coronavirus (SARS‐CoV) into rhesus macaques ( Macaca mulatta ) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 Immunological, molecular biological, and pathological studies support establishment of this model. Firstly, SARS‐CoV‐specific IgGs in sera from 11 to 60 Secondly, SARS‐CoV RNA could be pharyngeal swab...