A5048906828- Aquaculture disease management and microbiota
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Aquaculture Nutrition and Growth
- Identification and Quantification in Food
- Complement system in diseases
- Molecular Biology Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Rice Cultivation and Yield Improvement
- Genetic diversity and population structure
- Fish Biology and Ecology Studies
- Genetic and phenotypic traits in livestock
- Fish Ecology and Management Studies
- Physiological and biochemical adaptations
- interferon and immune responses
- Spectroscopy and Chemometric Analyses
- RNA modifications and cancer
- Circular RNAs in diseases
- Mosquito-borne diseases and control
- Immune Response and Inflammation
- Genomics and Phylogenetic Studies
- Plant Disease Resistance and Genetics
- Autophagy in Disease and Therapy
- Biomarkers in Disease Mechanisms
Shanghai Ocean University
2016-2025
Ministry of Agriculture and Rural Affairs
2020-2025
Shanghai Agrobiological Gene Center
2007-2025
Shandong Jiaotong University
2021-2025
Gansu Provincial Center for Disease Control and Prevention
2024
Changzhou University
2023-2024
Shanghai University of Traditional Chinese Medicine
2024
National Institutes of Health
2024
Traditional Chinese Medicine Hospital of Kunshan
2024
China Academy of Information and Communications Technology
2024
Arsenic poisoning affects millions of people worldwide. Human arsenic intake from rice consumption can be substantial because is particularly efficient in assimilating paddy soils, although the mechanism has not been elucidated. Here we report that two different types transporters mediate transport arsenite, predominant form soil, external medium to xylem. Transporters belonging NIP subfamily aquaporins are permeable arsenite but arsenate. Mutation OsNIP2;1 (Lsi1, a silicon influx...
The main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), known as 3CLpro, is crucial in virus's life cycle and plays a pivotal role COVID-19. Understanding how small molecules inhibit 3CLpro's activity vital for developing anti-COVID-19 therapeutics. To this end, we employed Gaussian accelerated molecular dynamics (GaMD) simulations to enhance sampling 3CLpro conformations conducted correlation network analysis (CNA) explore interactions between different...
Abstract A novel gene, OsAHL1, containing an AT-hook motif and a PPC domain was identified through genome-wide profiling analysis of mRNAs by comparing the microarray drought-challenged versus normally watered rice. The results indicated OsAHL1 has both drought avoidance tolerance that could greatly improve resistance rice plant. Overexpression enhanced multiple stress tolerances in plants during seedling panicle development stages. Functional studies revealed regulates root under condition...
1,2,4-Triazolo[4,3-a]pyridine derivatives represent a new series of compounds that possess good herbicidal activity against Echinochloa crusgalli (L.) Beauv., Setaria faberii, Digitaria sanguinalis Scop., Brassica juncea Coss., Amaranthus retroflexus L. and Eclipta prostrata L.A total 23 novel 1,2,4-triazolo[4,3-a]pyridine were synthesised identified by (1) H NMR, IR, single-crystal X-ray diffraction, mass-spectroscopic elemental analysis, their activities tested E. S. D. B. A. at 150 g a.i....
The grass carp (Ctenopharyngodon idella) is an important commercial farmed herbivorous fish species in China, but susceptible to Aeromonas hydrophila infections. In the present study, we performed de novo RNA-Seq sequencing of spleen tissue from specimens a disease-resistant family, which were given intra-peritoneal injections containing PBS with or without dose A. hydrophila. sampled control group at 0 h, and experimental 4, 8, 12, 24, 48 72 h. 122.18 million clean reads obtained normalized...
Genetic diversity within a species reflects population evolution, ecology, and ability to adapt. Genome-wide surveys of both natural introduced populations provide insights into genetic diversity, the evolutionary processes basis underlying local adaptation. Grass carp is most important freshwater foodfish for food water weed control. However, there as yet no overall picture on variations structure this species, which its aquaculture.We used 43,310 SNPs infer structure, evidence adaptation...
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design the CDK family. Multiple short dynamics (MD) simulations combined with MM-GBSA approach are adopted to investigate on binding selectivity X64, X3A, and 4 AU CDK6. The RMSF analysis calculations surface areas indicate that local structural global flexibility stronger than CDK2. Based cross-correlation maps (DCCMs), motion modes produce difference due associations...
Walking catfish (Clarias batrachus) is a freshwater fish capable of air-breathing and locomotion on land. It usually inhabits various low-oxygen habitats, burrows inside the mudflat, sometimes "walks" to search for suitable environments during summer. has evolved accessory organs respiring air corresponding mechanisms survive in such challenging environments. Thereby, it serves as great model understanding adaptations terrestrial life.Comparative genomics with channel (Ictalurus punctatus)...