A5101589954- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Diabetes and associated disorders
- IgG4-Related and Inflammatory Diseases
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Appendicitis Diagnosis and Management
- Pancreatic function and diabetes
- Helicobacter pylori-related gastroenterology studies
- Radiomics and Machine Learning in Medical Imaging
- Intestinal and Peritoneal Adhesions
- Wound Healing and Treatments
- Powdery Mildew Fungal Diseases
- Neuroendocrine Tumor Research Advances
- Enhanced Recovery After Surgery
- Abdominal Trauma and Injuries
- RNA modifications and cancer
- Diabetes Management and Research
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Beijing Proteome Research Center
2024-2025
Shanghai Jiao Tong University
2024
Shanghai Institute of Hematology
2024
State Key Laboratory of Proteomics
2024
First Affiliated Hospital Zhejiang University
2019-2024
Ministry of Agriculture and Rural Affairs
2024
Ruijin Hospital
2024
Shanghai Ocean University
2024
Lung cancer mortality is exacerbated by late-stage diagnosis. Emerging evidence indicates the potential clinical significance of distinct microbial signatures as diagnostic and prognostic biomarkers across various cancers. However, circulating microbiome DNA (cmDNA) profiles are underexplored in lung (LC). Here, whole-genome sequencing performed on plasma LC patients healthy controls (HCs). Differentially enriched species identified between HC. A model developed, which has a high sensitivity...
To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han lowlanders. We revealed collection candidate located 30 loci under selection. Among them, MCUR1 at 6p23 was novel pronounced candidate. By single-cell RNA comprehensive functional studies, demonstrated depletion leads impairment erythropoiesis hypoxia normoxia. Mechanistically,...
The objectives of this phase II study were to determine the clinical activity MET tyrosine kinase inhibitor capmatinib (INC280) in patients with MET-dysregulated advanced hepatocellular carcinoma (HCC) and assess safety, pharmacokinetics, correlation biomarkers response.This II, open-label, single-arm evaluated twice daily (BID) oral a dose-determining stage, utilizing Bayesian Logistic Regression Model (BLRM) subject Escalation Overdose Control criteria, pharmacodynamic information...
Objective: The purpose of this study was to evaluate the efficacy ultrasonography-guided percutaneous A1 pulley release with needle knife for trigger finger. Methods: prospective included 21 patients (21 fingers) who underwent blind and 20 (20 knife. thickness width pulley, clinical grade before after release, complications, operation time were compared between groups. Results: results showed that group had significantly better postoperatively reached 100% complete in one (p < 0.05)....
Background Chronic pancreatitis (CP) is a chronic inflammatory disease of the pancreas. This study aimed to compare natural course alcoholic (ACP) and idiopathic (ICP). Methods CP patients admitted our center from January 2000 December 2013 were enrolled. Characteristics compared between ACP ICP patients. Cumulative rates diabetes mellitus (DM), steatorrhea, pancreatic stone, pseudocyst, biliary stricture, cancer after onset diagnosis calculated, respectively. The cumulative DM steatorrhea...
Abstract Purpose To explore the role of indocyanine green (ICG) fluorescence navigation in laparoscopic hepatectomy and investigate if timing its administration influences intraoperative observation. Methods The subjects this retrospective study were 120 patients who underwent hepatectomy; divided into an ICG-FN group ( n = 57) a non-ICG-FN 63). We analyzed baseline data operative data. Results There no remarkable differences such as demographic characteristics, lesion-related liver function...
Abstract Chronic pancreatitis (CP) is characterized by persistent inflammation of the pancreas that results in progressive loss endocrine and exocrine compartment owing to atrophy and/or replacement with fibrotic tissue. Currently, clinical therapeutic scheme CP mainly symptomatic treatment including pancreatic enzyme replacement, glycaemic control nutritional support therapy, lacking specific drugs for prevention suppression fibrosis aggravating CP. Here, we investigated effect...
Abstract Background and Aim Pancreatic pseudocyst is a common complication of chronic pancreatitis. The identification risk factors development nomogram for pancreatic pseudocysts in pancreatitis patients may contribute to the early diagnosis intervention pseudocysts. Methods Patients with admitted our center from January 2000 December 2013 were enrolled. Cumulative rates after onset calculated. randomly assigned, 2:1 ratio, training validation cohort. Based on cohort, identified through Cox...
To identify the risk factors and develop nomograms for common bile duct (CBD) stricture in chronic pancreatitis (CP) patients.CBD is a complication CP has variable clinical presentation ranging from asymptomatic to overt jaundice cholangitis.Patients with admitted Changhai Hospital (Shanghai, China) January 2000 December 2013 were enrolled. Cumulative rates of CBD after onset diagnosis calculated. Patients randomly assigned, 2:1 ratio, training validation cohort. On basis cohort, symptomatic...
Abstract Background and Aim Pancreatic extracorporeal shock wave lithotripsy (P‐ESWL) is a first‐line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P‐EWSL in geriatric remains unclear. We aimed to evaluate safety efficacy P‐ESWL them. Methods This prospective study was conducted painful CP who underwent P‐ESWL. Patients aged over 65 years were included group; under assigned control group. For long‐term follow‐up investigation, matched...
Abstract Background and Aim Diabetes mellitus (DM) is a common complication of idiopathic chronic pancreatitis (ICP), which impairs the quality life for patients. This study aimed to identify risk factors develop nomogram DM in ICP help early diagnosis. Methods Idiopathic patients admitted our center from January 2000 December 2013 were included. Cumulative rates calculated by Kaplan–Meier method. Patients randomly assigned, 2:1 ratio, training validation cohort. Based on cohort, identified...
As a calcium-regulated protein, CaMK II is closely related to cell death, and it participates in the development of pathological processes such as reperfusion injury, myocardial infarction, oligodendrocyte death. The function activation acute pancreatitis (AP) remains unclear. In our study, we confirmed that expression p-CaMK was increased significantly consistently injured pancreatic tissues after caerulein-induced AP. Then, found KN93, an inhibitor II, could mitigate histopathological...
To build and assess a pre-treatment dual-energy CT-based clinical-radiomics nomogram for the individualized prediction of clinical response to systemic chemotherapy in advanced gastric cancer (AGC).A total 69 pathologically confirmed AGC patients who underwent CT before were enrolled from two centers this retrospective study. Treatment was determined with follow-up according RECIST standard. Quantitative radiomics metrics primary lesion extracted three sets monochromatic images (40, 70, 100...
All-trans retinoic acid (ATRA), an effective differentiation inducer, has been applied clinically to treat acute promyelocytic leukemia (APL). Unfortunately, it is not as potent in other kinds of myeloid (AML). Ethacrynic (EA), a classical powerful diuretic, can increase reactive oxygen species (ROS) contents, which assist ATRA inducing AML cells. Here, we investigated the effect EA combined with (EA+RA) on some cells except APL.
Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no document natural history CP.CP admitted center January 2000 December 2013 were enrolled. Patients assigned (< 18 years old) adult group according their age at onset Cumulative rates both groups calculated. Risk identified, respectively.The median follow-up duration...