A5100325725- Magnetic properties of thin films
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Autophagy in Disease and Therapy
- Physics of Superconductivity and Magnetism
- MicroRNA in disease regulation
- Cellular transport and secretion
- Lipid metabolism and biosynthesis
- Helicobacter pylori-related gastroenterology studies
- Photosynthetic Processes and Mechanisms
- Galectins and Cancer Biology
- Superconducting Materials and Applications
- Magnetic and transport properties of perovskites and related materials
- Plant nutrient uptake and metabolism
- Endoplasmic Reticulum Stress and Disease
- ZnO doping and properties
- Circular RNAs in diseases
- Plant Pathogens and Fungal Diseases
- Adsorption and biosorption for pollutant removal
- Advanced Graph Theory Research
- Magnetic Properties and Applications
- Quantum and electron transport phenomena
- Transgenic Plants and Applications
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
Zhejiang A & F University
2020-2025
Affiliated Hospital of Southwest Medical University
2024
Shanghai Huangpu District Central Hospital
2024
University of California, Santa Cruz
2017-2024
Peking University
2023-2024
Nanchang University
2024
Henan Provincial People's Hospital
2019-2024
Zhengzhou University
2021-2024
Second Affiliated Hospital of Nanchang University
2024
University of Science and Technology of China
2024
Abstract Current induced spin-orbit torques driven by the conventional spin Hall effect are widely used to manipulate magnetization. This approach, however, is nondeterministic and inefficient for switching of magnets with perpendicular magnetic anisotropy that demanded high-density storage memory devices. Here, we demonstrate this limitation can be overcome exploiting a in noncollinear antiferromagnets, such as Mn 3 Sn. The group symmetry Sn allows generation out-of-plane current carrying...
Abstract Due to its inherent superior perpendicular magnetocrystalline anisotropy, the FePt in L 1 0 phase enables magnetic storage and memory devices with ultrahigh capacity. However, reversing state, therefore encoding information, has proven be extremely difficult. Here, it is demonstrated that an electric current can exert a large spin torque on magnet, ultimately leading reversible magnetization switching. The monotonically increases increasing thickness, exhibiting bulk characteristic....
Abstract The endoplasmic reticulum (ER) is the major site for protein folding in eukaryotic cells. ER homeostasis essential development of an organism, whereby unfolded response (UPR) within precisely regulated. ER‐phagy a newly identified selective autophagic pathway removal misfolded or proteins mammalian Sec62, component translocon complex, was recently characterized as receptor during stress recovery phase mammals. In this study, we demonstrated that Arabidopsis Sec62 (AtSec62) required...
BackgroundCholesteryl ester (CE) accumulation in intracellular lipid droplets (LDs) is an essential signature of clear cell renal carcinoma (ccRCC), but its molecular mechanism and pathological significance remain elusive.MethodsEnabled by the label-free Raman spectromicroscopy, which integrated stimulated scattering microscopy with confocal spectroscopy on same platform, we quantitatively analyzed LD distribution composition at single level intact ccRCC tissue specimens situ without any...
Like many other filamentous ascomycetes, Fusarium graminearum contains two genes named CPK1 and CPK2 that encode the catalytic subunits of cyclic AMP (cAMP)-dependent protein kinase A (PKA). To determine role cAMP signaling in pathogenesis development F. graminearum, we functionally characterized these genes. In addition, generated cpk1 cpk2 double fac1 adenylate cyclase gene deletion mutants. The mutant was significantly reduced vegetative growth, conidiation, deoxynivalenol production but...
Plastid casein kinase 2 (CK2) is a major Ser/Thr-specific enzyme for protein phosphorylation in the chloroplast stroma and its activity regulated by redox signals. To understand role of CK2 proteins abiotic stress signalling, an Arabidopsis plastid (CKA4) knockout mutant was investigated terms plant response to abscisic acid (ABA) heat stress. CKA4 expression upregulated ABA treatment. The cka4 showed reduced sensitivity during seed germination seedling growth, increased stomatal aperture...
In the rice blast fungus Magnaporthe oryzae, cAMP-PKA pathway regulates surface recognition, appressorium turgor generation, and invasive growth. However, deletion of CPKA failed to block formation responses exogenous cAMP. this study, we generated characterized cpk2 cpkA mutants spontaneous suppressors in M. oryzae. Our results demonstrate that CPK2 have specific overlapping functions, PKA activity is essential for plant infection. Unlike single mutants, mutant was significantly reduced...
Redox modulators have been developed as an attractive approach to treat cancer. Herein, we report the synthesis, identification, and biological evaluation of a quinazolinedione reactive oxygen species (ROS) inducer, QD394, with significant cytotoxicity in pancreatic cancer cells. QD394 shows transcriptomic profile remarkably similar napabucasin, stemness inhibitor. Both small molecules inhibit STAT3 phosphorylation, increase cellular ROS, decrease GSH/GSSG ratio. Moreover, causes iron-...
Abstract Biofilm growth is a widespread mechanism that protects bacteria against harsh environments, antimicrobials, and immune responses. These types of conditions challenge chronic colonizers such as Helicobacter pylori but it not fully understood how H. biofilm defined its impact on survival. To provide insights into properties, we characterized formation abiotic biotic surfaces, identified genes required for formation, the biofilm-associated gene expression laboratory model strain G27....
Selective autophagy is a subcellular process whereby cytoplasmic materials are selectively sequestered into autophagosomes for subsequent delivery to the vacuole degradation and recycling. Arabidopsis (Arabidopsis thaliana) NBR1 (next BRCA1 gene 1 protein; AtNBR1) has been proposed function as selective receptor in plants, AtNBR1 anchors ubiquitinated targets degradation. However, specific cargos of remain elusive. We previously showed that exocyst subunit EXO70 family protein E2...
Vacuolar proteins play essential roles in plant physiology and development, but the factors machinery regulating their vesicle trafficking through endomembrane compartments remain largely unknown. We others have recently identified an evolutionarily conserved endosomal sorting complex required for transport (ESCRT)-associated protein apoptosis-linked gene-2 interacting X (ALIX), which plays canonical functions biogenesis of multivesicular body/prevacuolar compartment (MVB/PVC) ubiquitinated...
Helicobacter pylori is a gastric pathogen that infects nearly half of the global population and recognized as group 1 carcinogen by Word Health Organization. The rise in antibiotic resistance has increased clinical challenges treating H. infections. Biofilm growth been proposed to contribute pylori’s chronic colonization host stomach, treatment failures, eventual development diseases. Several components have identified promote biofilm growth, several these may also facilitate tolerance,...
Abstract Lipid droplets (LDs) stored during seed development are mobilized and provide essential energy lipids to support seedling growth upon germination. Triacylglycerols (TAGs) the main neutral in LDs. The lipase SUGAR DEPENDENT 1 (SDP1), which hydrolyzes TAGs Arabidopsis thaliana, is localized on peroxisomes traffics LD surface through peroxisomal extension, but underlying mechanism remains elusive. Here, we report a previously unknown function of plant-unique endosomal sorting complex...
The Mu Us Sandy Land is a key region of man-made desert control and farmland to forest (grass) return in China. Despite global change the strong influence human activities, vegetation this has been significantly improved restored. In study, multisource remote sensing data multiple indicators were used quantitatively monitor evaluate restoration status area. driving factors also analysed. results show that past 20 years, nearly entire substantively recovered. regional fractional cover...
Owing to the interplay between charge, spin, and orbits of electrons, spin-orbit torque (SOT) has attracted considerable interest during past decade. Despite substantial progress, existing quantification methods SOT still have their respective restrictions on magnetic anisotropy, entanglement effective fields, lack corrections for thermal gradient planar Hall effect. Thus, it is essential accurately characterize across diverse samples. In this study, with aim removing above-mentioned...
Bamboo is an important model plant to study the molecular mechanisms of rapid shoot growth and flowering once in a lifetime. However, bamboo research about protein functional characterization largely lagged behind, mainly due lack gene transformation platforms. In this study, protoplast transient expression system moso has been first established. Using reliable efficient system, we have generated set multicolored fluorescent markers based on targeting sequences from endogenous proteins,...
Abstract A higher available magnetic field can provide more flexibility for significant research and construction. Inserting a feasible high-temperature-superconducting (HTS) magnet inside low-temperature-superconducting (LTS) external is becoming an efficient method to build ultra-high-field (UHF) magnets. However, HTS insert magnets exhibited concentration of strain during the energization, significantly owing screening-current effect. This phenomenon affects structural integrity magnets,...
e20510 Background: Multiple clinical trials have reported the striking benefit for PD-1/PD-L1 monoclonal antibody combined with chemotherapy neoadjuvant therapy non-small cell lung cancer (NSCLC), while efficacy of subcutaneous injection anti-PD-L1 Envafolimab NSCLC patients has not been demonstrated yet. is a novel recombinant protein humanized camel-derived single-domain fused human IgG1 Fc fragment designed injection, making it easy to administer and improving patient compliance. This...