A5100354143- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Immunotherapy and Immune Responses
- Liver physiology and pathology
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Transplantation: Methods and Outcomes
- T-cell and B-cell Immunology
- Organ Donation and Transplantation
- Metabolism and Genetic Disorders
- Cancer Immunotherapy and Biomarkers
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- Muscle metabolism and nutrition
- Cellular Mechanics and Interactions
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- RNA modifications and cancer
Shanghai Jiao Tong University
2020-2024
Renji Hospital
2020-2024
Chongqing University of Arts and Sciences
2024
Shanghai Cancer Institute
2024
Nanjing Medical University
2010-2023
Capital Medical University
2023
XinHua Hospital
2020
State Key Laboratory of Oncogene and Related Genes
2020
Nanjing Drum Tower Hospital
2018-2020
Jiangsu Province Hospital
2006-2019
// Jie Ji 1, * , Junwei Tang Lei Deng Yu Xie 1 Runqiu Jiang Guoqiang Li Beicheng Sun Liver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China These authors have contributed equally to this work Correspondence to: Sun, e-mail: sunbc@njmu.edu.cn Keywords: lncRNA, HCC, EpCAM, mTOR, prognosis Received: April 27, 2015 Accepted: October 16, Published: 26, ABSTRACT...
Abstract We explored the role of micro RNA ‐30a (miR‐30a) and mechanism involved in hepatic fibrosis. MiR‐30a overexpression was achieved by miR‐30a mimics transfection stellate cells ( HSC s) ‐T6, LX ‐2), agomir (ago‐miR‐30a) treatment mice. levels were measured using TaqMan mi assay system, localization detected fluorescence situ hybridization FISH ). The interaction Beclin1 confirmed dual‐luciferase reporter assay. Autophagic flux analysed tandem mRFP ‐ GFP LC 3 microscopy, electron...
In this study, we characterized the expression of 32 other kinesin superfamily proteins (KIFs) and analyzed their association with progression prognosis hepatocellular carcinoma (HCC).The data from 295 HCC patients The Cancer Genome Atlas were included in study. An independent t-test was used to compare KIF levels adjacent tissues. Pearson's Chi-square test assess relationships tumor biomarkers clinicopathological parameters. Kaplan-Meier plots log-rank tests analyze survival, univariate...
CCAAT/enhancer binding protein (C/EBP)-homologous (CHOP) has been shown to be a key molecule in endoplasmic reticulum (ER) stress-mediated apoptosis. ER oxidoreductin 1-α (ERO1α), target of CHOP, is an important oxidizing enzyme that regulates reactive oxygen species (ROS), which play prominent role hepatocellular death during acute liver failure (ALF). However, little known about how CHOP facilitates ROS-induced injury. The present study was designed investigate the roles and molecular...
Ischemia-reperfusion (I/R) associated with small-for-size liver transplantation (SFSLT) impairs graft regeneration. Mesenchymal stem cells (MSCs) have the capability, under specific conditions, of differentiating into hepatocytes. Hepatocyte growth factor (HGF) has potent anti-apoptotic and mitogenic effects on hepatocytes during injury, been utilized in many experimental clinical applications. In this study, we implanted HGF-expressing MSCs grafts via portal vein, using a 30% rat model....
Long non-coding RNAs (lncRNAs) play essential roles in diverse biological processes; however, current understanding of the mechanism underlying regulation tumour proliferation and metastasis is limited. Lung cancer-associated transcript 1 (LUCAT1) has been reported a variety human cancers, while its role hepatocellular carcinoma (HCC) remains unclear. This study aimed to determine LUCAT1 on progression HCC cells clinical specimens. Our results demonstrated that was up-regulated tissues...
Background Low-dose lipopolysaccharide (LPS) preconditioning-induced liver protection has been demonstrated during ischemia-reperfusion injury (IRI) in several organs but not sufficiently elucidated underlying causal mechanism. This study investigated the role of low-dose LPS preconditioning on ATF4-CHOP pathway as well effects tissue and inflammation a mouse model partial-warm IRI. Methods (100 µg/kg/d) was injected intraperitoneally two days before ischemia. Hepatic evaluated based serum...
Background. Although orthotopic liver transplantation provides a therapeutic option for patients with Wilson's disease (WD) presenting fulminant failure or drug resistance, it is still unclear whether the living-related (LRLT) can result in long-term effect on WD. Methods. Here, we report retrospective analysis of LRLT 36 cases WD patients. The indications were hepatic two and chronic advanced 32 including 13 Wilsonian neurologic manifestations. Two presented severe manifestations even...
Circular RNAs (circRNAs) are a class of non-coding broadly expressed in cells various species. However, the contributions and molecular mechanisms circRNAs to hepatocellular carcinoma (HCC) remain largely unknown. In present study, we compared expression between five paired HCC adjacent noncancerous liver (ANL) tissues by using RNA-sequencing (RNA-seq). circRASGRF2 (a circRNA located on chromosome 5 derived from RASGRF2, hsa_circ_0073181) was identified validated quantitative reverse...
Abstract Background Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma. The major challenges for current therapies are the low efficacy drugs occurrence drug resistant HBV mutations. RNA interference (RNAi) virus-specific genes offers possibility developing a new anti-HBV therapy. Recent reports have shown that lentiviral vectors based on HIV-1 promising gene delivery vehicles due to their ability integrate transgenes into non-dividing...
Abstract Background Long noncoding RNAs (lncRNA) represent significant factors of the mammalian transcriptome that mediates varied biological and pathological processes. The liver is most common site for gallbladder cancer (GBC) distant metastasis contributes to majority GBC‐related death. How lncRNA affects GBC not completely understood. Results A novel termed lncGALM (lncRNA in associated with metastasis) was discovered be highly expressed patients xenografted tumors metastasis. Elevated...
Exome sequencing has become a formidable tool for identifying potential de novo variants in causative genes of human diseases, such as neurodegenerative disorders. This article describes 16-month-old girl with spinal muscular atrophy lower extremity predominance and 13-month-old malformations cortical development. identified novel heterozygous missense mutation c.3395G>A (p.Gly1132Glu) previously reported c.10151G>A (p.Arg3384Gln) the DYNC1H1 gene. Bioinformatics predictions indicated...