A5100386332- Oral microbiology and periodontitis research
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Endometriosis Research and Treatment
- Hepatitis B Virus Studies
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Cytokine Signaling Pathways and Interactions
- Sepsis Diagnosis and Treatment
- Dental Radiography and Imaging
- Respiratory viral infections research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
Nanjing Medical University
2016-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Institute of Hematology & Blood Diseases Hospital
2025
Qufu Normal University
2025
Gdansk University of Physical Education and Sport
2025
Shandong Agricultural University
2025
Southern Medical University
2018-2024
Jiangsu Province Hospital
2016-2024
Chengdu University of Traditional Chinese Medicine
2024
Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at single-cell resolution.The osteoimmunology microenvironment in the occurrence and development periodontitis remains poorly understood level.In this study, we used transcriptomics to comprehensively reveal complexities molecular components differences with counterparts residing periodontal tissues.Methods: We performed scRNA-seq identify 51248 single cells from healthy controls (n=4), patients severe...
This study aimed to develop and validate an interpretable machine-learning model based on clinical features for early predicting in-hospital mortality in critically ill patients with sepsis.We enrolled all sepsis the Medical Information Mart Intensive Care IV (MIMIC-IV, v.1.0) database from 2008 2019. Lasso regression was used feature selection. Seven methods were applied models. The best selected its accuracy area under curve (AUC) validation cohort. Furthermore, we employed SHapley...
Stem cell-independent reprogramming of differentiated cells has recently been identified as an important paradigm for repairing injured tissues. Following periportal injury, mature hepatocytes re-activate reprogramming/progenitor-related genes (RRGs) and dedifferentiate into liver progenitor-like (LPLCs) in both mice humans, which contribute remarkably to regeneration. However, it remains unknown how external factors trigger hepatocyte reprogramming. Here, by employing single-cell...
The purpose of this study was to ascertain the relative contribution neural stem/progenitor cells (NSPCs) subventricular zone (SVZ) lineages that repopulate injured striatum following focal ischemia. We utilized a tamoxifen-inducible Cre/loxP system under control nestin promoter, which provides permanent YFP labeling multipotent nestin(+) SVZ-NSPCs prior ischemic injury and continued expression in all subsequent progeny stroke. reporter induced adult male nestin-CreER(T2):R26R-YFP mice by...
Human adipose-derived mesenchymal stem cells-conditioned medium (ADSC-CM) contains cytokines and growth factors that can facilitate the regeneration repair of various tissues organs. In present study, protective activity ADSC-CM treatment was investigated in UVB-irradiated human keratinocyte cell line HaCaTs normal dermal fibroblasts (NHDFs). It found modulate expression signaling molecules early UVB responsive pathways, including mitogen activated protein kinases (MAPKs), activator 1...
Electrospinning technique has attracted considerable attention in fabrication of cellulose nanofibrils or nanocellulose membranes, which polycaprolactone (PCL) could be used as a promising precursor to prepare various nanofibril membranes for periodontal tissue regeneration. Conventional bio-membranes and films guided regeneration (GTR) can prevent the downgrowth epithelial cells, fibroblasts, connective area tooth root but have limitations related osteogenic antimicrobial properties....
Activation of the stimulator interferon genes (STING) is essential for blocking viral infections and eliciting antitumor immune responses. Local injection synthetic STING agonists, such as 2′3′-cGAMP [cGAMP = cyclic 5′-guanosine monophosphate (cGMP)–adenosine (AMP)], a promising approach to enhance antiviral functions cancer immunotherapy. However, application agonists has been hindered by complicated procedures, high doses, unsatisfactory systemic Herein, we report design synthesis series...
The outer membrane vesicles (OMVs) produced by Porphyromonas gingivalis contain a variety of bioactive molecules that may be involved in the progression periodontitis. However, participation P. OMVs development periodontitis has not been elucidated. Here, we isolated and confirmed their both vivo vitro. Microcomputed tomography (micro-CT) histological analysis showed under stimulation with OMVs, alveolar bone rats was significantly resorbed vivo. We found were taken up human periodontal...
Fruit ripening is a complex process in the final phase of fruit development, which determines quality and nutrient composition fleshy fruits. In present study, total phenolics, antioxidant activity metabolic characteristics peach fruits named "Jinlinghuanglu" during were investigated. Four stages considered including unripe, semi-ripe, fully ripe overripe. Our result showed that both phenolics decreased gradually with ripening. Metabolomics demonstrated most synthesis-related amino acids...
Uncontrolled hyperuricemia often leads to the development of hyperuricemic nephropathy (HN), characterized by excessive inflammation and oxidative stress. Piperine, a cinnamic acid alkaloid, possesses various pharmacological activities, such as antioxidant anti-inflammatory effects. In this study, we intended investigate protective effects piperine on adenine potassium oxonate-induced HN mice uric-acid-induced injury model in renal tubular epithelial cells (mRTECs). We observed that...
ABSTRACT Organoid technology, as a revolutionary biomedical tool, has shown immense potential in haematological research recent years. By using three‐dimensional (3D) cell culture systems constructed from pluripotent stem cells (PSCs) or adult (ASCs), organoids can highly mimic the characteristics of vivo organs, thereby offering significant for investigating human organ development, disease processes and treatment strategies. This review introduces development focuses on their progress...
Actin-based cytoskeletons have been implicated in insulin-stimulated glucose transport and translocation of the insulin-regulated transporter, GLUT4, from intracellular pool to plasma membrane. However, most previous studies were done using adherent cell systems such as L6 myotubes 3T3-L1 adipocytes, very little information is available on significance actin filaments insulin action isolated a widely used experimental system. In present study, we investigated physiological role subcellular...
Erythropoietin (Epo) regulates the proliferation and differentiation of erythroid precursors. The phosphorylation proteins at tyrosine residues is critical in growth signaling induced by Epo. This mechanism regulated activities both protein-tyrosine kinases protein phosphatases. discovery phosphotyrosine phosphatases that contain SH2 domains suggests roles for these molecules factor pathways. We found Syp, a phosphatase, widely expressed all tissues mammals became phosphorylated on after...
Zhao L. Zhou Y, Xu Sun Li L, Chen W. Effect of non-surgical periodontal therapy on the levels Th17/Th1/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patients. J Clin Periodontol 2011; doi: 10.1111/j.1600-051X.2011.01712.x. Abstract Aim: A new subset CD4+ T cells, Th17, has been recently discovered independent from Th1/Th2 paradigm. The aim this study was to investigate effects expression factors, Th17 cell vibration Materials methods: (IL-17,...
The aim of this study was to evaluate the cytotoxic and apoptotic effects piperine on human lung cancer A549 cells explore its mechanisms. Piperine found exert greatest effect against in a dose-dependent manner, whereas it showed no WI38 fibroblasts. This cell growth-inhibitory might be attributed DNA damage effects. Besides, had ability cause cycle arrest G2/M phase activate caspase-3 caspase-9 cascades cells. Furthermore, piperine-induced apoptosis could blocked by broad caspase inhibitor...
Interleukin-17 (IL-17 or IL-17A), a pleiotropic cytokine produced by T helper (Th) 17 cells, is involved in the pathogenesis of various autoimmune and inflammatory disorders, including periodontitis. Although ability pro-inflammation periodontitis have been widely investigated, other biological functions IL-17, its role bone remodeling underlying molecular mechanism, not well clarified. In present study, IL-17 could significantly enhance expression receptor activator for nuclear factor-κB...