A5020543101- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Ferroptosis and cancer prognosis
- Facial Trauma and Fracture Management
- Cancer-related molecular mechanisms research
- Gout, Hyperuricemia, Uric Acid
- Adipokines, Inflammation, and Metabolic Diseases
- Fungal Biology and Applications
- Cancer-related Molecular Pathways
- Gene expression and cancer classification
- Acupuncture Treatment Research Studies
- Gut microbiota and health
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Mycorrhizal Fungi and Plant Interactions
- Traditional Chinese Medicine Studies
- Case Reports on Hematomas
- Inflammasome and immune disorders
- Silymarin and Mushroom Poisoning
- Colorectal Cancer Treatments and Studies
- Thyroid and Parathyroid Surgery
- Traumatic Brain Injury and Neurovascular Disturbances
- Reconstructive Facial Surgery Techniques
- DNA Repair Mechanisms
National Natural Science Foundation of China
2023
Southern Medical University
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Guangxi Medical University
2022-2023
Creative Commons
2023
Wuzhou Red Cross Hospital
2023
Guangzhou University of Chinese Medicine
2019-2022
Foshan Hospital of TCM
2020-2022
Guangdong Academy of Sciences
2020-2022
Hangzhou Medical College
2021
Abstract Breast cancer is a heterogeneous disease, affecting over 3.5 million women worldwide, yet the functional role of cis-regulatory elements including super-enhancers in different breast subtypes remains poorly characterized. Triple-negative (TNBC) an aggressive subtype with poor prognosis. Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between subtypes, provide clinically relevant biological insights towards TNBC. Using...
Chlorogenic acid, as a secondary metabolite of plants, exhibits variety effects including free radical scavenging, antiseptic, anti‑inflammatory and anti‑viral, in addition to its ability reduce blood glucose, protect the liver act an anti‑hyperlipidemic agent cholagogue. The present study demonstrated that administration chlorogenic acid alleviated spinal cord injury (SCI) via activity mediated by nuclear factor (NF)‑κB p38 signaling pathways. Wistar rats were used structure SCI model rat...
Accumulating evidence has shown that chronic injection of D-galactose (D-gal) can mimic natural ageing and induce liver kidney injury. Previous studies showed D-gal increased uric acid (UA) levels in mice. The increase UA caused inflammation, accelerated oxidative stress, aggravated Oxidative stress inflammation play vital roles the process. Therefore, reducing mice improved Glucose transporter 9 (GLUT9) is responsible for reabsorption body, its inhibition helps downregulate levels. present...
Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related mortality worldwide, with early detection being crucial for improving patient survival rates. However, screening HCC using ultrasound suffers from insufficient sensitivity and is highly dependent on expertise radiologists interpretation. Leveraging latest advancements in artificial intelligence (AI) medical imaging, this study proposes an innovative Hierarchical Sparse Query Transformer (HSQformer) model that...
Noninvasive diagnostic technologies that can dynamically monitor changes in liver inflammation are highly important for the management of chronic hepatitis B (CHB) patients and thus warrant further exploration. This study assessed efficacy FibroScan CHB patients.A total 1185 were selected, ultrasound-guided biopsy was performed within 1 month after test. The stiffness measurement (LSM), reliability criteria (IQR/M) LSM, quality (complete portal area, PA), grades main observation items this...
Diabetic retinopathy (DR) is one of the most common causes blindness and visual impairment.Therefore, early prediction its occurrence progression important.This study aimed to assess clinical predictive significance plasma fibrinogen concentrations combined monocyte-lymphocyte ratio (FC-MLR) in patients with DR.A total 307 type 2 diabetes (T2D) were enrolled.Plasma peripheral white blood cells measured, MLR was calculated, associations FC-MLR DR severity disease assessed.Regression analysis...
Hyperuricemia (HUA) is associated with left ventricular remodeling (LVR) and thereby causes the initiation development of a large number cardiovascular diseases. LVR typically accompanied by cardiomyocyte energy metabolic disorder. The supply cardiomyocytes provided glucose fatty acid (FA) metabolism. Currently, effect HUA on cardiomyocytic FA metabolism unclear. In this study, we demonstrate that UA-induced injury cytoplasmic lipid deposition, which can be ameliorated metabolism-promoting...
Abstract Numerous studies in plants have shown the vital roles of MYB transcription factors signal transduction, developmental regulation, biotic/abiotic stress responses and secondary metabolism regulation. However, less is known about functions MYBs Ganoderma. In this study, five medicinal macrofungi genus Ganoderma were subjected to a genome-wide comparative analysis genes. A total 75 genes identified classified into four types: 1R-MYBs (52), 2R-MYBs (19), 3R-MYBs (2) 4R-MYBs (2). Gene...
Objective This study was performed to investigate the risk factors for severe hypocalcemia (SH) after total parathyroidectomy without autotransplantation (TPTX) in patients with secondary hyperparathyroidism. Methods We retrospectively analyzed records of 136 hyperparathyroidism treated by TPTX. The were categorized as having SH or non-SH based on their postoperative blood calcium concentration. identified comparing clinical characteristics between two groups and performing multiple logistic...
Cellular cytoplasmic xanthine oxidase (XO)-mediated uric acid synthesis and extracellular excess exposure are both causes of cardiomyocytic injury under the condition hyperuricemia (HUA). Potassium oxonate suppresses degradation to increase concentration, while hypoxanthine is catalytic substrate XO. We aimed observe cardiac damage in a chronic HUA mouse model induced by potassium hypoxanthine. The was established co-administration for eight weeks. Then, left ventricular parameters were...
p38 plays a critical role in the proliferation, survival, migration and metastasis of colorectal cancer (CRC) cells. The present study assessed correlation between single nucleotide polymorphism (SNP) p38β promoter region (rs2235356, ‑1628A>G) predisposition individuals to sporadic CRC case‑control study. A genotyping method was developed detect this SNP, using polymerase chain reaction-restriction fragment length (PCR‑RFLP) analysis. logistic regression analysis used determine odds ratio...
C-Jun plays important roles in the development of multiple cancers, but no well-designed association studies have been conducted to assess its genetic polymorphisms cancer risk. In a cohort 1016 pairs colorectal (CRC) patients and matched cancer-free controls, we investigated two promoter regions c-Jun (rs4646999, -673C > T rs2760501, -1318T G) via Taqman assay evaluated between risk CRC. We found that both -1318G variant genotypes were associated with an increased CRC [-1318TG: odds ratio...
Ganoderma lucidum has a wide carbon spectrum, while the expression profile of key genes relevant to metabolism on different sources been seldom studied. Here, transcriptomes G. mycelia cultured each 19 were conducted. In comparison with glucose, 16 1,006 upregulated and 7 1,865 downregulated. Significant gene dynamics induced activity observed in laccase when using agricultural forestry residues (AFRs) as solo sources. Furthermore, study family two haploids GL0102 was Totally, 15 identified...
Triple-negative breast cancer (TNBC) is one of the more aggressive subtypes cancer. The prognosis TNBC patients remains low. Therefore, there still a need to continue identifying novel biomarkers improve and treatment patients. Research in recent years has shown that effective use integration information genomic data image will contribute prediction diseases. Considering imaging genetics can deeply study influence microscopic genetic variation on disease phenotype, this paper proposes sample...
Abstract Background Breast cancer is a malignant tumour that seriously threatens women’s life and health exhibits high inter-individual heterogeneity, emphasising the need for more in-depth research on its pathogenesis. While internal 7-methylguanosine (m7G) modifications affect RNA processing function are believed to be involved in human diseases, little currently known about role of m7G modification breast cancer. Methods Results We elucidated expression, copy number variation incidence...
Three-dimensional digital technology has been widely applied in craniofacial surgeries, particularly conventional procedures such as facial contouring and orthognathic surgery. To some extent, the process already standardized. As to reconstruction surgeries of complex deformity, however, surgical plans need be patient-specific. Traditionally, individualized treatment largely relies on surgeon's clinical experience. The application mainly focuses preoperative planning postoperative evaluation...
Objective To explore the clinical effect of digital technology and positioning with three-dimensional printing template which were applied systematically in treatment craniosynostosis secondary to orbital hypertelorism. Methods There 4 cases congenital premature closure unilateral coronal suture hypertelorism treated Plastic Surgery Hospital, Chinese Academy Medical Sciences from June 2015 August 2019, including 1 male 3 females, aged 8 years. The operation fronto-orbital advancement...
Abstract Background: To explore the potential biological characteristics of traditional Chinese medicine(TCM) syndromes in CHB patients is great significance to improve level TCM treatment.This study was designed gut microbiota with two most common Syndromes. Methods: According diagnostic criteria Western medicine, and screening exclusion criteria, 65 cases damp heat syndrome 28 liver depression spleen deficiency were finally included study. All basic information gathered fresh fecal samples...
Background: It is important for clinical diagnosis and therapeutic effect monitoring of chronic hepatitis B(CHB) to evaluate liver inflammation by noninvasive method. Fibroscan based on the transient elastography (TE) techniques a method widely used in evaluation fibrosis. We aimed assess efficacy patients with CHB. Methods: Ultrasound-guided biopsy was completed within one month after FibroScan testing 1,185 CHB patients.The reliability criteria detection are as follows:ratio interquartile...
Background: It is important for chronic hepatitis B(CHB) to evaluate liver inflammation by noninvasive method. Fibroscan based on the transient elastography (TE) techniques a method widely used in evaluation of fibrosis. We aimed assess efficacy diagnosis patients with CHB.Methods: Ultrasound-guided biopsy was completed within one month after FibroScan testing 1,185 CHB patients. Both reliability criteria( interquartile range median,IQR/M) and quality biopsy(complete portal tracts, CPTs)...
Large skull defects can result in chronic injury to intracranial tissues as well psychological trauma for patients, and their repair presents a challenge surgeons. Hydroxyapatite has been used reconstructing many years, but it is difficult adjust the shape size of material intraoperatively, especially large defects. With three-dimensional digital technology, new type customized composite implant made epoxide acrylate maleic hydroxyapatite applied clinical practice. In this retrospective...
Background: Accumulating evidence suggested that bone marrow mesenchymal stem cells (BMSCs) have therapeutic potential for diabetes and heart diseases. However, the effects of BMSC on reducing myocardial fibrosis need to be optimized. This study aimed investigate mechanism adiponectin (APN) modified BMSCs in diabetic model vivo vitro.Methods: The high-fat diet (HFD) combined with streptozotocin (STZ) injection were used induced DCM rat H9c2 cultured under a high glucose medium. by APN...