A5060404340- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Parathyroid Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Cerebrospinal fluid and hydrocephalus
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Fetal and Pediatric Neurological Disorders
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Alcohol Consumption and Health Effects
- Head and Neck Surgical Oncology
- MRI in cancer diagnosis
- Spinal Dysraphism and Malformations
- Neurosurgical Procedures and Complications
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Pancreatic and Hepatic Oncology Research
- Obstructive Sleep Apnea Research
Sun Yat-sen University
2016-2025
Huazhong University of Science and Technology
2024-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2006-2025
Tongji Hospital
2025
Inner Mongolia University of Finance and Economics
2025
Southwest University
2016-2025
Union Hospital
2024
Jiangnan University
2024
Wuxi Fourth People's Hospital
2024
Heme oxygenase-1 (HO-1) has been implicated in cardiac dysfunction, oxidative stress, inflammation, apoptosis and autophagy associated with heart failure, atherosclerosis, addition to its recognized role metabolic syndrome diabetes. Numerous studies have presented contradictory findings about the of HO-1 diabetic cardiomyopathy (DCM). In this study, we explored myocardial myofibril structure, using a streptozotocin (STZ)-induced diabetes model mice systemically overexpressing (Tg-HO-1) or...
Vascular calcification (VC) is regarded as an important pathological change lacking effective treatment and associated with high mortality. Sirtuin 6 (SIRT6) a member of the family, class III histone deacetylase key epigenetic regulator. SIRT6 has protective role in patients chronic kidney disease (CKD). However, exact molecular mechanism VC CKD remain unclear. Here, we demonstrated that was markedly downregulated peripheral blood mononuclear cells (PBMCs) radial artery tissue VC....
BackgroundConcern has been increasing in oncology regarding randomized clinical trial (RCT) eligibility limiting the generalizability of findings to real-world populations. Using a large US electronic health record database, we investigated from recent RCTs for relapsed and/or refractory multiple myeloma (RRMM).Patients and MethodsPatients with RRMM initiating second-to fourth-line therapy control arm following were retrospectively identified categorized as "RCT eligible" or ineligible"...
Since epoxyeicosatrienoic acids (EETs) affect sodium reabsorption in renal tubules and dilate the vasculature, we have examined their effects on hemodynamics balance male rats fed a high-fat (HF) diet by fenofibrate, peroxisome proliferator-activated receptor-α (PPAR-α) agonist an inducer of cytochrome P-450 (CYP) epoxygenases; N-methanesulfonyl-6-(2-proparyloxyphenyl)hexanamide (MSPPOH), selective EET biosynthesis inhibitor; 12-(3-adamantane-1-yl-ureido)dodecanoic acid (AUDA), inhibitor...
Abstract Background. Treatment of multiple myeloma has dramatically improved with the introduction bortezomib (BOR), thalidomide (THAL), and lenalidomide (LEN). Studies assessing health care costs, particularly economic burden on patients, are limited. We conducted a claims-based, retrospective analysis total costs as well patient (patient out-of-pocket number ambulatory/hospital visits) associated BOR/THAL/LEN treatment versus other therapies (OTHER). Methods. episodes starting between...
Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation vascular smooth muscle cells (VSMCs) a key mechanism VC. Recent studies show that IL-18 (interleukin-18) favors VC while TRPM7 (transient receptor potential melastatin 7) channel upregulation inhibits However, the relationship between unclear. We questioned whether enhances osteogenic VSMCs through activation.Coronary artery serum were measured in patients by computed...
Abstract The outlook for transplant-ineligible multiple myeloma patients has improved enormously over recent years with the incorporation of new agents into standard regimens. Novel regimens combine melphalan and prednisone (MP) bortezomib (VMP), thalidomide (MPT), lenalidomide (MPR-R) without (MPR) maintenance. efficacy, safety, cost-effectiveness these have not yet been compared; therefore, we conducted a pharmacoeconomic analysis using data from randomized controlled trials versus MP....
The pathogenesis of coronary artery calcification (CAC) in heart disease (CHD) is mediated by exosomes derived from vascular smooth muscle cells (VSMCs). However, little known about their underlying mechanism. In this study, we aimed to investigate the differentially expressed miRNAs VSMCs undergoing induced calcification. A cellular model was established using mouse VSMC line MOVAS-1. Calcium deposition evaluated Alizarin Red staining. Exosome sizes were determined Nanoparticle Tracking...
The aim of the present paper was to investigate promoting activity borneol on transdermal permeation drugs with differing lipophilicity, and probe its alterations in molecular organization stratum corneum (SC) lipids. toxicity evaluated epidermal keratinocyte HaCaT dermal fibroblast CCC-HSF-1 cell cultures compared known enhancers, irritant profile also assessed by transepidermal water loss (TEWL) evaluation. effect five model drugs, namely 5-fluorouracil, antipyrine, aspirin, salicylic acid...
Vascular calcification (VC) predicts the morbidity and mortality in cardiovascular diseases. smooth muscle cells (VSMCs) osteogenic transdifferentiation is crucial pathological basis for VC. To date, molecular pathogenesis still largely unclear. Notably, C5a-C5aR1 contributes to development of diseases, its closely related physiological bone mineralization which similar VSMCs transdifferentiation. However, role underlying mechanisms VC remain unexplored.
Lack of head-to-head trials highlights a need for comparative real-world evidence proteasome inhibitors plus Rd.Methods: In this retrospective, US population-representative EHR study RRMM patients initiating IRd, KRd, or VRd in line therapy (LOT) ≥2 between 1/2014 and 9/30/2018, 664 were treated LOT with: n = 168; 208; VRd, 357. Median age was 71/65/71 years; 67%/70%/75% had frailtymodified score intermediate/frail; 20%/28%/13% high cytogenetic risk I-/K-/V-Rd groups. Risk PI-triplet...
Background: Chronic kidney diseases (CKD) are usually associated with dyslipidemia. Statin therapy has been primarily recommended for the prevention of cardiovascular risk in patients CKD; however, effects statins on disease progression remain controversial. This study aims to investigate statin treatment renal handling water and animals a high-fat diet. Methods: Retrospective cohort patient data were reviewed protein expression levels aquaporin-2 (AQP2) NLRP3 inflammasome adaptor ASC...
Abstract Multiple available combinations of proteasome inhibitors, immunomodulators (IMIDs), and monoclonal antibodies are shifting the relapsed/refractory multiple myeloma (RRMM) treatment landscape. Lack head-to-head trials triplet regimens highlights need for real-world (RW) evidence. We conducted an RW comparative effectiveness analysis bortezomib (V), carfilzomib (K), ixazomib (I), daratumumab (D) combined with either lenalidomide or pomalidomide plus dexamethasone (Rd Pd) in RRMM. A...