Reduced health-related quality of life (HRQoL) is common in patients with hypoparathyroidism treated conventionally calcium and active vitamin D supplements.To examine the effects recombinant human parathyroid hormone [rhPTH(1-84)] on HRQoL as measured by 36-Item Short-Form Health Survey (SF-36) during a multinational, randomized, placebo-controlled study.Adults (N = 122) chronic hypoparathyroidism.After an optimization period when and/or supplements were adjusted to reach target serum...

Abstract The outlook for transplant-ineligible multiple myeloma patients has improved enormously over recent years with the incorporation of new agents into standard regimens. Novel regimens combine melphalan and prednisone (MP) bortezomib (VMP), thalidomide (MPT), lenalidomide (MPR-R) without (MPR) maintenance. efficacy, safety, cost-effectiveness these have not yet been compared; therefore, we conducted a pharmacoeconomic analysis using data from randomized controlled trials versus MP....

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorders and negatively impacts caregivers' lives. Factors including barriers to accessing care, dissatisfaction with support services, lack caregiver resources may contribute this.To report experiences ADHD diagnosis, behavioral therapy (BT), supportive care for children/adolescents ADHD.The Caregiver Perspective on Pediatric (CAPPA) survey included caregivers (6-17 years) from ten European...

Abstract Background Teduglutide reduces or eliminates parenteral support (PS) dependency in patients with short bowel syndrome (SBS). Recent post hoc analyses demonstrated that effects are correlated baseline PS volume. We assessed the SBS‐related quality‐of‐life (QoL) impact of teduglutide, particularly whether improvements greater among subgroups achieving more volume reduction. Methods Using phase 3 trial data teduglutide SBS (NCT00798967), change Short Bowel Syndrome–Quality Life...

To assess the effectiveness, safety, and treatment patterns of anti-angiogenic agents in metastatic renal cell carcinoma (mRCC) tertiary clinical practice settings.We retrospectively reviewed medical records two oncology centres USA for all patients treated while off trials from April 2003 to June 2008 who met entry criteria received one or more prescriptions sunitinib sorafenib, intravenous administrations bevacizumab (off-label) as first-line treatment. The objective response rate (ORR) by...

Background: Burden on caregivers of children/adolescents with attention-deficit/hyperactivity disorder (ADHD) is multidimensional, but incompletely understood. Objective: To analyze caregiver burden across the concepts work, social/family life, and parental worry/stress, in relation to selected contributing factors. Methods: The online Caregiver Perspective Pediatric ADHD survey was fielded ten European countries. Analysis included (6–17 years) who were receiving/had received pharmacotherapy...

To address knowledge gaps regarding burdens associated with not adequately controlled chronic hypoparathyroidism.Global patient and caregiver survey.Patients hypoparathyroidism on conventional therapy their caregivers.Health-related quality of life (HRQoL) health status were evaluated using the 36-item Short Form version 2 (SF-36 v2.0) Five-Level EuroQoL 5 Dimensions (EQ-5D-5L) instruments, respectively. Hypoparathyroidism-associated symptoms assessed by a disease-specific Hypoparathyroidism...

Chronic hypoparathyroidism, treated with conventional therapy of oral calcium supplements and active vitamin D, may increase the risk kidney complications. This study examined risks development progression chronic disease (CKD) estimated glomerular filtration rate (eGFR) decline in patients hypoparathyroidism. A retrospective cohort using a managed care claims database United States from January 2007 to June 2017 included hypoparathyroidism (excluding those receiving parathyroid hormone)...

Chronic hypoparathyroidism managed with conventional treatment, comprising oral administration of calcium and active vitamin D, has been associated renal complications, including nephrolithiasis nephrocalcinosis. Further larger-scale studies are needed to examine these risks. This study evaluated the risk nephrocalcinosis in patients chronic hypoparathyroidism. A retrospective cohort using a care claims database United States from January 2007 June 2017. Included were those (excluding...

Multikinase inhibitors (MKIs) sunitinib and sorafenib have become a standard of care for metastatic renal cell carcinoma (mRCC). This study assessed safety treatment patterns these agents in real-world clinical practice setting Italy.A retrospective medical record review was performed at tertiary oncology center Italy. The included MKI-naïve non-trial patients ≥18 years old, with histological diagnosis mRCC, who received or as first MKI during 9/2005-7/2008. Data were collected on adverse...

Aims: To assess the real-world clinical burden and healthcare resource utilization (HRU) among patients with chronic hypoparathyroidism, overall by adequately controlled (AC) vs not (NAC) disease, informed guideline-recommended management targets, including biochemistry symptoms. Materials methods: In this retrospective online chart review, endocrinologists in US, Canada, UK, France, Germany, Italy, Spain were randomly selected to review medical charts of adult hypoparathyroidism receiving...

Abstract Context Chronic hypoparathyroidism (HypoPT) is conventionally managed with oral calcium and active vitamin D. Recombinant human parathyroid hormone (1–84) (rhPTH[1–84]) a therapy targeting the pathophysiology of HypoPT by replacing hormone. Objective To compare changes in estimated glomerular filtration rate (eGFR) patients chronic receiving or not rhPTH(1–84) during 5-year period. Design/Setting A retrospective analysis treated without rhPTH(1–84). Patients Sixty-nine from 4...

This study aimed to identify predictors and estimate time teduglutide response among adult patients with short bowel syndrome intestinal failure (SBS-IF) dependent on parenteral support (PS).Post-hoc analysis was performed individual patient data from teduglutide-treated in the phase III trial STEPS STEPS-2 extension. Response defined as ≥20% PS volume reduction baseline for two consecutive visits. Early responders experienced at 20 24 weeks during while late STEPS-2. Timing were assessed...

Patients with short-bowel syndrome and intestinal failure (SBS-IF) require parenteral support (PS) may need long-term home-care support. This survey assessed the impact of care provision on adult caregivers patients receiving PS for SBS-IF.An online, cross-sectional adults a self-reported physician diagnosis SBS-IF was conducted in France, Germany, Italy, UK, USA. Impact evaluated using 18-item Caregiver Strain Index (CSI), Work Productivity Activity Impairment Questionnaire: Specific Health...

Abstract Background: Real-world evidence on treatment patterns and healthcare resource use (HRU) in patients receiving the targeted therapies encorafenib+binimetinib (ENCO+BINI) dabrafenib+trametinib (DAB+TRAM) mMEL is limited. Methods: Patients initiating ENCO+BINI or DAB+TRAM between June 2018 March 2023 as first-line (1L) second-line (2L) for IQVIA Pharmetrics® Plus commercial claims database were included. judged to have received neoadjuvant adjuvant therapy another cancer prior TT...

In patients with chronic hypoparathyroidism disordered calcium homeostasis has been associated risk of cardiovascular diseases, including cardiomyopathy, congestive heart failure, and arrhythmia; however, larger-scale studies are needed to examine these risks. This study evaluated the conditions among hypoparathyroidism.Adults without were selected from a medical insurance claims database in USA January 2007 June 2017, followed for up 5 years. Associations between incident atrial...

Purpose:To conduct an initial psychometric evaluation of the reliability and validity Hypoparathyroidism Symptom Diary (HPT-SD).Patients methods: Data were collected during a cross-sectional, observational study.Participants with self-reported hypoparathyroidism (HPT) completed HPT-SD, Functional Assessment in Cancer Therapy-Cognitive Function (FACT-Cog), Chronic Illness Therapy-Fatigue (FACIT-Fatigue), Hospital Anxiety Depression Scale (HADS) measures.Item-and scale-level internal...

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental that affects the lives of patients and their families. The Caregiver Perspective on Paediatric ADHD (CAPPA) survey was conducted to evaluate burden associated with in Europe identify unmet needs. Here, we describe sociodemographic clinical characteristics, treatment use impact ADHD.The cross-sectional web-based CAPPA fielded 10 European countries among caregivers children/adolescents (aged 6-17 years) who were currently...

Purpose: Teduglutide, a glucagon-like peptide-2 analog, has demonstrated efficacy in reducing parenteral support (PS) among patients with short bowel syndrome intestinal failure (SBS-IF).This study aims to identify subpopulation of SBS-IF for whom teduglutide an especially pronounced effect.Patients and methods: Data were from 24-week, Phase III trial (Study Teduglutide Effectiveness Parenteral Nutrition-Dependent SBS Subjects; NCT00798967) that randomized PS dependency receive (n=43) or...

Abstract The renal status of patients with bone metastases secondary to solid tumors and their treatment nephrotoxic agents is not well characterized. This retrospective study analyzed electronic medical records data from US ‐based oncology clinics identify adult (age ≥18) tumor first metastasis diagnosis ≥1 serum creatinine recorded between January 1, 2009 December 31, 2013. Patients multiple myeloma, primary types, acute failure, and/or end‐stage disease were excluded. Using the Chronic...