A5063537486- Cardiac Imaging and Diagnostics
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Ultrasound in Clinical Applications
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Advanced X-ray and CT Imaging
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Ultrasound and Cavitation Phenomena
- Cardiac electrophysiology and arrhythmias
- Hemodynamic Monitoring and Therapy
- Thermoregulation and physiological responses
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Ultrasound Imaging and Elastography
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Eicosanoids and Hypertension Pharmacology
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Cardiovascular Effects of Exercise
- Thyroid and Parathyroid Surgery
Oregon Health & Science University
2015-2024
University of Portland
2007-2023
Oregon State University
2020
VA Portland Health Care System
2017-2019
Cincinnati Children's Hospital Medical Center
2017
University of Cincinnati Medical Center
2017
Doernbecher Children's Hospital
2017
Toronto General Hospital
2017
University of Cincinnati
2017
Cardiovascular Institute of the South
2013-2016
Background —Ultrasound can cause microbubble destruction. If microbubbles are administered as a continuous infusion, then their destruction within the myocardium and measurement of myocardial reappearance rate at steady state will provide measure mean velocity. Conversely, concentration an assessment microvascular cross-sectional area. Myocardial blood flow (MBF) be calculated from product two. Methods Results —Ex vivo in vitro experiments were performed which either was held constant...
We hypothesized that successful reperfusion of an occluded infarct-related coronary artery even late after acute myocardial infarction would result in improved regional wall motion and such improvement might be related to the presence collateral blood flow within infarct bed.
Obesity is the major risk factor for metabolic syndrome and through it diabetes as well cardiovascular disease. Visceral fat (VF) rather than subcutaneous (SF) predictor of adverse events. Currently, reference standard measuring VF abdominal X-ray computed tomography (CT) or magnetic resonance imaging (MRI), requiring highly used clinical equipment. Dual-energy absorptiometry (DXA) can accurately measure body composition with high-precision, low exposure, short-scanning time. The purpose...
BACKGROUND Although many patients with multivessel coronary artery disease (CAD) and severely depressed left ventricular (LV) function will benefit from bypass graft surgery (CABG), surgeons may be reluctant to perform CABG on these without evidence of myocardial viability in regions severe asynergy. We hypothesized that quantitative planar rest-redistribution 201Tl imaging would identify viable myocardium predict improved regional global after revascularization LV CAD. METHODS AND RESULTS...
Background —Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and characterize any resultant bioeffects. Methods Results —Intravital microscopy used visualize the spinotrapezius muscle 15 rats during ultrasound delivery. Microbubble exposure caused rupture of ≤7-μm microvessels (mostly capillaries) production nonviable cells adjacent tissue. The number ruptured damaged correlated linearly ( P <0.001) with amount energy delivered. Conclusions...
Angiogenesis is a critical determinant of tumor growth and metastasis. We hypothesized that contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins expressed on the neovascular endothelium could be used image angiogenesis.Malignant gliomas were produced in 14 athymic rats by intracerebral implantation U87MG human glioma cells. On day or 28 after implantation, CEU was performed alpha(v)beta3 surface conjugation echistatin. perfusion imaging nontargeted derive...
Background —We have previously shown that the application of ultrasound to thin-shelled microbubbles flowing through small microvessels (<7 μm in diameter) produces vessel wall ruptures vivo. Because many intravascular drug- and gene-delivery vehicles are limited by endothelial barrier, we hypothesized this phenomenon could be used deliver drug-bearing tissue. Methods Results —An exteriorized rat spinotrapezius muscle preparation was used. Intravascular fluorescent red blood cells polymer...
BACKGROUND Patency of the infarct-related artery (IRA) after acute myocardial infarction (AMI) may not reflect magnitude tissue perfusion. In animal models AMI, cellular necrosis has been associated with extensive capillary damage. Because contrast echocardiography (MCE) can define spatial distribution microvascular perfusion, we hypothesized that it could be used in patients recent AMI to distinguish regions have an intact microvasculature and thus are viable from those without viable....
Background— Noninvasive methods for characterizing neovessel formation during angiogenesis are currently lacking. We hypothesized that could be imaged with the use of contrast-enhanced ultrasound (CEU) microbubbles targeted to α v -integrins. Methods and Results— Microbubbles -integrins were prepared by conjugating echistatin (MB E ) or monoclonal antibody against murine their surface. Control c also prepared. The microvascular behavior these was assessed intravital microscopy cremaster...
Background —Lipid microbubbles used for perfusion imaging with ultrasound are retained within inflamed tissue because of complement-mediated attachment to leukocytes venules. We hypothesized that incorporation phosphatidylserine (PS) into the microbubble shell may enhance these interactions by amplifying complement activation and thereby allow inflammation. Methods Results —In 6 mice, intravital microscopy necrosis factor-α–treated cremaster muscle was performed assess microvascular behavior...
The purpose of this study was to determine whether the behavior sonicated albumin microbubbles accurately mimics red blood cell flow in microcirculation and is thus consistent with their use as vivo tracers during myocardial contrast echocardiography. Accordingly, prepared from fluorescein-conjugated fluorescently labeled cells were injected intravascularly eight golden hamsters. Their intravascular distribution, velocities, arteriolar-to-venular transit flux ratios at branch points...
BACKGROUND Papillary muscle dysfunction (PMD) has been implicated in the pathogenesis of ischemic mitral regurgitation (MR). We hypothesized that MR is not caused by PMD and/or myocardial regions from where papillary muscles arise but related to reduction global left ventricular (LV) function. To test this hypothesis, three groups dogs were studied. METHODS AND RESULTS In group 1 (n = 8), varying degrees regional and LV produced. 2 7), circulation was isolated rest LV. Dysfunction one or...